Recombinant Human Inactive heparanase-2 (HPSE2)

1. The results of this study the Heparanase 2 appeared overexpressed at different stages of Alzheimer disease. PMID: 28387673
2. our results suggest that heparanase 2 functions as a tumor suppressor in bladder cancer PMID: 26968815
3. we provide evidence that Hpa2 overexpression in head and neck cancer cells markedly reduces tumor growth PMID: 27013193
4. The most common HPA genotypes among Saudis were HPA-1 a + b- (75%), HPA-2 a + b- (62%), HPA-3 a + b- (51.5%), HPA-4 a + b- (99%), HPA-5 a + b- (76.5%), HPA-6 a + b- (100%) and HPA-15 a + b + (50%). The prevalent allele among the HPA systems was (a), except in the HPA-15 system where the (b) allele was found in 52% of the subjects. PMID: 27019315
5. Our findings identified these 2 genes as a novel breast cancer biomarker gene set, which may facilitate the diagnosis and treatment in breast cancer clinical therapies. PMID: 26084486
6. HPSE2 mutations were found in one Urofacial syndrome family but not detected in patients with non-neurogenic neurogenic bladder and severe lower urinary tract dysfunction PMID: 25924634
7. Heparanase 2 is more intensely expressed in the glandular tissue of cancer than in nonneoplastic endometrium; the HPSE2 expression in the stromal tissue is higher in the nonneoplastic controls compared with cancer mainly in the secretory endometrium. PMID: 25423319
8. autonomic neural protein implicated in bladder emptying PMID: 25145936
9. High expression of heparanase-2 is associated significantly with gastric tumor growth and differentiation PMID: 24139593
10. Data indicate that the overexpression of HPSE1 and HPSE2 in the intervertebral degenerated discs suggests a role for these factors in mediating extracellular matrix remodeling in degenerative discs during disease development. PMID: 23370684
11. HPSE2 c.631T>C (p.Y211H) is a novel benign SNP and c.1628A>T (p.N543I) is the disease-causing mutation in urofacial syndrome. PMID: 21332471
12. A large region of marker homozygosity was observed at 10q24, consistent with known autosomal recessive inheritance, family consanguinity and previous genetic mapping in other families with Ochoa syndrome. PMID: 21450525
13. Studies indicate that cathepsin L as the heparanase activating protease. PMID: 21308479
14. These results indicate a regulatory effect of heparanase on TFPI and TFPI-2 in trophoblasts, suggesting a potential involvement of heparanase in early miscarriages. PMID: 20031192
15. We now report evidence that Heparanse 2 (HPSE2) is the culprit gene for the syndrome. Mutations with a loss of function in the Heparanase 2 (HPSE2) gene PMID: 20560209
16. Homozygous exonic deletions, nonsense mutations, and frameshift mutations in five further unrelated families confirmed HPSE2 as the causative gene for UFS PMID: 20560210
17. Results demonstrated that the effectors from heparanase peptide-immunized mice could effectively lyse various tumor cells that were heparanase positive and HLA-A*0201 matched. PMID: 20182872
18. Heparanase 2 is involved in neoplastic proliferation, but it was not exclusively associated with the malignant process. PMID: 19955924
19. Heparanase may facilitate invasion and metastasis of gastric carcinoma cells. PMID: 15475937
20. Study demonstrating that increased heparanase expression in prostate cancer tissues is due to promoter hypomethylation and up-regulation of transcription factor EGR1. PMID: 15709168
21. Heparanase expression seems to be involved in the invasiveness and aggressiveness of head and neck squamous cell carcinomas. PMID: 15837740
22. Heparanase expression is inversely correlated with survival of nasopharyngeal carcinoma (NPC) patients, indicating heparanase is a reliable prognostic factor, and further supports that heparanase is a valid target for the development of anti-cancer drugs. PMID: 16879396
23. HPSE plays a role in extracellular matrix remodeling and in increasing heparin-binding growth factor release during embryo implantation. PMID: 17989358
24. Data suggest that loss of modified heparan sulphate in the GBM is mediated by an increased heparanase presence and may play a role in the pathogenesis of diabetes-induced proteinuria. PMID: 18058084

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HGNC: 18374

OMIM: 236730

KEGG: hsa:60495

STRING: 9606.ENSP00000359583

UniGene: Hs.500750