Recombinant Human Histone-lysine N-methyltransferase PRDM9 (PRDM9), partial

1. These results support the hypothesis that ow-copy repeats 22 variations influences 22q11.2 non-allelic homologous recombination events, however further studies are needed to confirm this association and clarify the contribution of pseudogenes and rare PDRM9 alleles to non-allelic homologous recombination susceptibility for DiGeorge/velocardiofacial syndrome. PMID: 28059126
2. Finally, the authors demonstrate that, in addition to binding DNA, PRDM9's zinc fingers also mediate its multimerization, and they show that a pair of highly diverged alleles preferentially form homo-multimers. PMID: 29072575
3. The most common genetic variant of PRDM9 is allele A (PRDM9a) which contains 13 Cys2-His2 zinc fingers (ZF); the second-most common variant among African populations is allele C (PRDM9c), which contains 14 Cys2-His2 ZF. Data suggest that Ser764 in ZF9 allows PRDM9c to accommodate a variable base, whereas PRDM9a Arg764 recognizes a conserved guanine. PMID: 28801461
4. The article outlines the role of PRDM9 in fertility. PMID: 27045445
5. Allele C was found to bind a C-specific hot spot with higher affinity than allele A bound A-specific hot spots PMID: 26833727
6. PRDM9 protein variants form functional heteromeric complexes which can bind hotspots sequences. When a heteromeric complex binds at a hotspot of one PRDM9 variant, the other PRDM9 variant, which would otherwise not bind, methylates hotspot nucleosomes PMID: 26368021
7. subspecies-specific degradation of PRDM9 binding sites by meiotic drive, which steadily increases asymmetric PRDM9 binding, has impacts beyond simply changing hotspot positions, and strongly support a direct involvement in hybrid infertility PMID: 26840484
8. Alignment of Neandertal and Denisovan sequences suggests that PRDM9 in archaic hominins was closely related to present-day human alleles that are rare and specific to African populations. PMID: 25001002
9. This depletion of PRDM9 genomic targets is expected to decrease fitness, and thereby to favor new PRDM9 alleles binding different motifs PMID: 25393762
10. Results confirm an association between rare variant PRDM9 alleic forms and childhood ALL PMID: 24754746
11. Overexpression of PRDM9 in HEK293 cells also resulted in a significant increase in trimethylated H3K36 and H3K4 further confirming our in vitro observations PMID: 24634223
12. We identified PRDM9 as being associated with unusual recombination patterns and discovered a substantial excess of rare allelic forms of PRDM9 in two independent acute lymphoblastic leukemia cohorts. PMID: 23222848
13. Recombination regulator PRDM9 influences the instability of its own coding sequence in humans. PMID: 23267059
14. observed a increased frequency of PRDM9 variants in parents who transmitted de novo 7q11.23 deletions to their offspring. These data suggest that certain PRDM9 alleles may be associated with an increased susceptibility to recurrent 7q11.23 microdeletions PMID: 22643917
15. discussion of role of PRDM9 in meiotic recombination hotspots; consideration of the structure of the PRDM9 protein [REVIEW] PMID: 22162947
16. Each African-enhanced hotspot is activated by a distinct spectrum of PRDM9 variants, despite the fact that all are predicted to bind the same motif. This differential activation points to complex interactions between the zinc-finger array and hotspots. PMID: 21750151
17. PRDM9 variation strongly influences recombination hot-spot activity and meiotic instability. PMID: 20818382
18. Human coding polymorphism and interspecies evolutionary changes in the PRDM9 gene, was analyzed. PMID: 20041164
19. sequence of exon 12 of PRDM9; human populations exhibit two predominant alleles and multiple minor alleles of Prdm9 PMID: 20044538
20. results provide a molecular basis for the distribution of meiotic recombination in mammals in which the binding of PRDM9 to specific DNA sequences targets the initiation of recombination at specific locations in the genome PMID: 20044539
21. findings implicate the PRDM9 gene in meiotic recombination; involvement of PRDM9, which causes histone H3 lysine 4 trimethylation, implies that there is a common mechanism for recombination hotspots in eukaryotes PMID: 20044541
22. Results show a possible association between PRDM9 and azoospermia by meiotic arrest. PMID: 18941885
23. Our results suggest that mutations in PRDM9 may cause idiopathic infertility in human males. PMID: 19168450
24. Evolutionary analysis suggests that human PRDM7 and PRDM9 genes, a pair of close paralogs corresponding to a single mouse gene Prdm9, were generated by a recent gene duplication event after the divergence of the ancestors of human and mouse. PMID: 18231586

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HGNC: 13994

OMIM: 609760

KEGG: hsa:56979

STRING: 9606.ENSP00000296682

UniGene: Hs.283096