Recombinant Human Homeobox protein Hox-A9 (HOXA9)

1. MiR-182/HOXA9 was involved in the process of RUNX3-mediated GC tumor growth. PMID: 29054094
2. The present study demonstrated that miR-139-5p, functioning as a suppressor in the tumorigenesis process, suppressed oral squamous carcinoma cells mobility by targeting HOXA9 directly. PMID: 28780773
3. NHA9 (NUP98-HOXA9 fusion protein) deregulates the expression of key leukemic genes, including MEIS1-HOXA9-PBX3 complex, through the enhancer binding and the direct interaction of the fusion protein with HDAC and p300 transcriptional regulators PMID: 28630438
4. Results show that a combination of HOXA9 and HOXA10 promoter methylation markers is significantly associated with the prognosis of breast cancer patients a subtype-independent manner. PMID: 28748001
5. knockdown of HOXA9 abrogated NAC1induced drug resistance. PMID: 28713930
6. HOXA9 expression is upregulated in three-dimensional organotypic culture of claudin-low breast cancer cells. PMID: 27409175
7. HOXA9 transcriptionally regulated EPHB4 expression to modulate trophoblasts migration and invasion, which may suggest a contribution of HOXA9-EPHB4 in the poor placentation in the pathogenesis of preeclampsia. PMID: 28292467
8. HOTTIP/WDR5/HOXA9/Wnt axis contributes to pancreatic tumor stem cell stemness. PMID: 28947139
9. Beta-catenin regulates expression of downstream targets of a key transcriptional memory gene, Hoxa9 that is highly enriched in myeloid leukemia cancer stem cells and helps sustain leukemic self-renewal. PMID: 28978671
10. This is the first time the protein partners of either E2A-PBX1 or HOXA9 oncoproteins were identified using an unbiased biochemical approach. The identification of translation initiation factors associated with HOXA9 might indicate a novel function for HOX proteins independent of their transcriptional activity. PMID: 28707666
11. The HOXA9 moiety of NUP98-HOXA9 is essential for binding to the Hoxa gene locus. MLL is important for the recruitment of NUP98-HOXA9 to the HOXA locus and for NUP98-HOXA9-induced HOXA gene expression. PMID: 28210005
12. In the present study, we found in a translational stepwise approach that promoter DNA methylation of the homeobox (HOX) gene HOXA9 could help predict resistance or response to cisplatin-based chemotherapy in patients with bladder cancer PMID: 27598218
13. DYNLT1 interacts with nucleoporins and plays a role in the dysregulation of gene expression and induction of hematopoietic cell proliferation by the leukemogenic nucleoporin fusion, NUP98-HOXA9 PMID: 23840580
14. Low HOXA9 expression is associated with Non Small Cell Lung Cancer. PMID: 27880728
15. This study identified HOXA9 as a target gene of miR-196b and determined that the mechanism of miR-196b-mediated epithelial-to-mesenchymal transition and invasion processes involves the regulation of HOXA9 expression in non-small cell lung cancer cells. PMID: 26586336
16. Advanced glycation end products could induce endothelial cell dysfunction through NF-kappaB dependent HoxA9 downregulation. PMID: 28723696
17. HOXA9 role in acute myeloid leukemia. PMID: 28399410
18. NUP98-HOXA9 ability to induce blood cell expansion is evolutionarily conserved. PMID: 27838340
19. Homeobox A9 (HOXA9) expression was inversely correlated with microRNA miR-196b levels in recurrent epithelial ovarian cancer (EOC). PMID: 28387653
20. Promoter variants in HOXA9, TPM1, and TPM2, alter promoter expression suggesting that they have a functional role in clubfoot. PMID: 27020427
21. Controlling HOXA9 expression appears to be a necessary step during CC development. PMID: 27039722
22. The results indicate that highly selective targeting of Nup98-fusion proteins to Hox cluster regions via prebound Crm1 induces the formation of higher order chromatin structures that causes aberrant Hox gene regulation. PMID: 26740045
23. Study found that hypermethylation of CpG probes in the promoter regions of HOXA9 and PCDH10 was associated with mature B-cell neoplasms. PMID: 26679037
24. With continued advances in understanding HOXA9-mediated transformation, there is a wealth of opportunity for developing novel therapeutics that would be applicable for greater than 50% of AML with overexpression of HOXA9 PMID: 26028034
25. Data establish HOXA9 as a driver of glioma initiation, aggressiveness and resistance to therapy. PMID: 25762636
26. Concurrent ISL1/HOXA9 methylation in HG-NMIBC reliably predicted tumour recurrence and progression within one year, and was associated with disease-specific mortality PMID: 26332997
27. Increased expression of HOXA9 is associated with acute myeloid leukemia. PMID: 25987065
28. Pbx3 contributes to Hoxa9 leukemogenesis through stabilization of the Meis1 protein. PMID: 26130510
29. HOXA9 and MEIS1 overexpression are inversely correlated with relapse and overall survival, so the genes could become useful predictive markers of the clinical course of pediatric acute leukemias. PMID: 26059450
30. present study suggests that HOXA9 inhibits migration of lung cancer cells and its hypermethylation is an independent prognostic factor for recurrence-free survival in never-smokers with NSCLC PMID: 24817037
31. these findings indicate that homeobox A9 regulates the expression of VEGF in epidermal stem cells PMID: 25031718
32. HOXA9 methylation is frequent in oral cancers and levels are higher in tumors with greater risk of metastasis. Expression of HOXA9 is low in cells with high levels of methylation and reduced expression appears to confer a growth advantage. PMID: 24886209
33. HOXA9 methylation could be detected in plasma from HCC patients (n=40) but not in normal plasma (n=34) (p<0.0005). PMID: 24681432
34. Different gain-of-function and loss-of-function studies reveal that HOXA9 enhances hematopoietic differentiation of embryonic stem cells by specifically promoting the commitment of hemogenic precursors into primitive and total CD45(+) blood cells. PMID: 25185710
35. These findings indicate that HOXA9 contributes to poor outcomes in Epithelial ovarian cancer in part by promoting intraperitoneal dissemination via its induction of P-cadherin. PMID: 25023983
36. we define a three-gene panel, CDO1, HOXA9, and TAC1, which we subsequently validate in two independent cohorts of primary NSCLC samples PMID: 24486589
37. Hoxa9T on its own induced acute myeloid leukemia after a similar latency as Hoxa9FLim, despite its inability to bind DNA PMID: 24535405
38. HOXA9 may, therefore, stimulate ovarian cancer progression by promoting an immunosuppressive microenvironment via paracrine effects on peritoneal macrophages. PMID: 24332016
39. Cell growth and function are dependent on maintained levels of signature gene HOXA9. PMID: 23539541
40. The complete remission rate of the patients who expressed the gene was significantly lower than that in patients who did not express the gene after chemotherapy. PMID: 23575938
41. A low level of expression of miR-196b can cause up-regulation of BCR-ABL1 and HOXA9 expression, which leads to the development of chronic myeloid leukemia. PMID: 23894305
42. Symplekin interacts and co-localizes with both MOZ and MLL in immature hematopoietic cells. Its inhibition leads to a decrease of the HOXA9 protein level but not of Hoxa9 mRNA. PMID: 23994619
43. hypermethylation of HIST1H4F, PCDHGB6, NPBWR1, ALX1, and HOXA9 was significantly associated with shorter survival in stage 1 Non-small-cell lung cancer PMID: 24081945
44. HOXA9 acts as an oncogene in laryngeal squamous cell carcinoma, promoting tumor cell proliferation and migration. PMID: 24308157
45. SALL4 binds a specific region of the HOXA9 promoter in leukemic cells. PMID: 24051379
46. The methylation status of Homeobox A9 (HOXA9), ISL LIM homeobox 1 (ISL1) and Aldehyde dehydrogenase 1 family, member A3 (ALDH1A3) was significantly associated with decreased gene expression levels PMID: 23436614
47. The competition for this binding site inhibits the expression of HOXA9 and induces different transcriptional outcomes, which suggests a new direction for investigation of the mechanism underlying targeted therapy of malignant gliomas. PMID: 23466061
48. Data indicate that the genes comprising the HMGA2-TET1-HOXA9 pathway are coordinately regulated in breast cancer and together encompass a prognostic signature for patient survival. PMID: 23716660
49. High expression of HOXA9 is associated with the occurrence of acute leukemia, and its expression level is significantly higher in children with AML than in those with ALL. PMID: 23607948
50. Data indicate that retroviral transduction-mediated overexpression or siRNA-mediated knock-down of Hoxa9 respectively down-regulated or up-regulated Geminin in hematopoietic cells. PMID: 23326393

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HGNC: 5109

OMIM: 142956

KEGG: hsa:3205

STRING: 9606.ENSP00000343619

UniGene: Hs.659350