Recombinant Human Inactive dipeptidyl peptidase 10 (DPP10), partial

1. These results show that a Dpp10 point mutation leads to increased airway responsiveness following allergen challenge. PMID: 29361513
2. The DPP10 duplication is likely a benign CNV polymorphism enriched in Southern Chinese with a population frequency of ~1%. PMID: 28670437
3. The stoichiometry of the Kv4.2-DPP10 complex was variable depending on the relative expression level of each subunit, with a preference for 4:2 stoichiometry PMID: 26209633
4. the interaction of DPP10a, expressed in human atrium, with Kv4.3 channels generates a sustained current component of Ito, which may affect late repolarization phase of atrial action potentials. PMID: 25600224
5. study suggests a genetic contribution of DPP10 rs17048175 in eosinophilic inflammation induction in the airways and to aspirin-exacerbated respiratory disease susceptibility PMID: 25592153
6. Our results suggest that DPP10(789) is involved in the pathology of AD and other neurodegenerative diseases. PMID: 25025038
7. demonstrated that glycosylation was necessary for both DPP10 trafficking to the cell surface and functional interaction with Kv4 channels PMID: 22387313
8. Crystals of DPP10 obtained by the sitting-drop method were orthorhombic, belonging to space group P2(1)2(1)2(1) with unit-cell parameters a = 80.91, b = 143.73, c = 176.25 A. PMID: 22298003
9. N-linked glycosylation of DPP10 plays an important role in modulating Kv4.3 channel/KCHIP2 complex activities. PMID: 20354865
10. We were unable to confirm associations of single nucleotide polymorphisms of the positional candidates DPP10 and PHF11 with wheeze. Significant associations with reported and examined eczema were only observed for DPP10. PMID: 20085599
11. Our study is the first one to provide additional evidence that supports the roles of DPP10 in influencing asthma or BHR in a Chinese population PMID: 19951440
12. rs10208402 associated with percentage of peripheral blood eosinophils and log(e)-transformed total IgE in a Han Chinese population PMID: 19672052
13. cloning, characterization and mapping to chromosome 2 PMID: 12662155
14. Interaction between transmembranes of DPP10/DPPX and Kv4 channel mediates functional complex formation. We call this protein DPPY, instead of DPP10, because of its revealed role as a Kv4 channel regulator. PMID: 15911355
15. although similar in structure and sequence to other dipeptidyl peptidases, it lacks vital residues required for dipeptidyl peptidase activity and has instead evolved features that enable it to act as a component of voltage-gated potassium channels PMID: 16290253
16. Data show that in the Kv4.2+KChIP3+DPP10 channel complex, all DPP10 variants accelerate channel gating kinetics; however, the splice variant DPP10a produces uniquely fast inactivation kinetics that accelerates with increasing depolarization. PMID: 17475505
17. No consistent association was found between DPP10 and asthma susceptibility. PMID: 17702965
18. REVIEW: role in health and disease PMID: 19676137

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HGNC: 20823

OMIM: 600807

KEGG: hsa:57628

STRING: 9606.ENSP00000376855

UniGene: Hs.580539