Recombinant Human Interleukin-17 receptor D(IL17RD),partial

Code CSB-YP847706HU
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Source Yeast
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Code CSB-EP847706HU
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Source E.coli
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Code CSB-EP847706HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP847706HU
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Source Baculovirus
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Code CSB-MP847706HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names IL17RD
Uniprot No. Q8NFM7
Alternative Names DKFZp434N1928; FLJ35755; hSef; I17RD_HUMAN; IL 17 receptor D; IL 17RD; IL-17 receptor D; IL-17RD; IL17 receptor D; il17rd; IL17Rhom; IL17RLM; Interleukin 17 receptor D; Interleukin 17 receptor like protein; Interleukin-17 receptor D; Interleukin-17 receptor-like protein; Interleukin17 receptor D; MGC133309; SEF; Sef homolog
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Might have a role in the early stages of fate specification of GnRH-secreting neurons. Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells.
Gene References into Functions
  1. miR-193a-3p is downregulated in ulcerative colitis neoplasia, and its loss promotes carcinogenesis through upregulation of IL17RD. These findings provide novel insight into inflammation-driven colorectal cancer and could suggest new therapeutic targets in this high-risk population PMID: 28600480
  2. Low SEF expression is associated with Epithelial-Mesenchymal Transition in Breast Cancer and thus Metastasis in breast Cancer. PMID: 26950413
  3. Taken together, these data suggest evidence that loss of hSef may be a critical event facilitating tumor dissemination of prostate cancer through alteration of EMT. PMID: 28073170
  4. IL17RD negatively regulates Toll-like receptor (TLR)-induced responses. PMID: 25808990
  5. Demonstrate SEF expression in a healthy ovary during folliculogenesis and suggest hormonal regulation of its expression may be an important factor involved in intra-ovarian control mechanisms. PMID: 25118304
  6. Downregulation of Dusp6, Sprouty4, and Sef--negative modulators of FGF2/ERK1/2 signaling--was present in eutopic endometria of adenomyosis, which may play critical roles in the development of adenomyosis. PMID: 24681741
  7. These results reveal Sef-S actives Lys63-linked TAK1 polyubiquitination on lysine 209, induces TAK1-mediated JNK and p38 activation and also results apoptosis in 293T cells. PMID: 23770285
  8. FGF17 and IL17RD prpopsed as the two top candidates in the entire proteome on the basis of a statistical test of their protein-protein interaction patterns to proteins known to be altered in congenital hypogonadotropic hypogonadism. PMID: 23643382
  9. Downregulation of SEF mRNA is associated with prostate cancer. PMID: 23169297
  10. Orphan receptor IL-17RD tunes IL-17A signalling and is required for neutrophilia. PMID: 23047677
  11. This study establishes Sef as a feedback antagonist of proinflammatory cytokines and highlights its potential to regulate the crosstalk between proinflammatory cytokine receptors and receptor tyrosine kinases. PMID: 22975329
  12. The expression of hSef is decreased in epithelial ovarian carcinoma tissue, but the expression of FGF-2 is increased. PMID: 22335910
  13. Findings indicate that Ras-induced nuclear accumulation of activated MEK1/2 was reliant on downregulation of the spatial regulator Sef. PMID: 22298595
  14. Sef exerts its inhibitory effects at the level of FGFR and upstream of Ras providing an additional level of negative regulation of FGF signaling PMID: 12604616
  15. human SEF is likely to play critical roles in endothelial or epithelial functions such as proliferation, migration, and angiogenesis PMID: 12807873
  16. HSef acts as a spatial regulator for ERK signaling by targeting ERK to the cytoplasm. PMID: 15239952
  17. Sef binds to TAK1 and has a role in JNK activation and apoptosis PMID: 15277532
  18. Sef is downregulated in advanced prostate cancer and might facilitate an enhanced tumorigenic response to FGFs PMID: 16474841
  19. Sef inhibited FGF induced, but not RasG12V mediated, signal transduction. We propose that Sef interacted with Ras in the inhibition of Ras/MAPK signaling pathway. PMID: 16859641
  20. hSef isoforms can control signal specificity and subsequent cell fate by utilizing different mechanisms to modulate RTK signaling PMID: 17035228
  21. Inhibitory effect of hSef on cell proliferation combined with consistent downregulation in human carcinoma indicates a tumor suppressor-like role for Sef. PMID: 17420726
  22. Sef plays a positive role in the EGF/EGFR-mediated MAPK signaling pathway. PMID: 18096367
  23. IL 17RD protein is a part of the Interleukin-17 receptor signaling complex, therefore providing novel evidence for Interleukin-17 signaling through a heteromeric and/or homomeric receptor complex. PMID: 19079364
  24. CUG codon functions as a major translation initiation site in the alternatively spliced transcript variant hSef-b. PMID: 14742870

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Involvement in disease Hypogonadotropic hypogonadism 18 with or without anosmia (HH18)
Subcellular Location Golgi apparatus membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Note=Predominantly associated with the Golgi apparatus and is partially translocated to the plasma membrane upon stimulation.; [Isoform 4]: Cytoplasm.
Tissue Specificity Expressed in umbilical vein endothelial cells and in several highly vascularized tissues such as kidney, colon, skeletal muscle, heart and small intestine. Highly expressed in ductal epithelial cells of salivary glands, seminal vesicles and the collecting
Database Links

HGNC: 17616

OMIM: 606807

KEGG: hsa:54756

STRING: 9606.ENSP00000296318

UniGene: Hs.150725

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