This Recombinant human Junctional protein associated with coronary artery disease (JCAD) is a semi-custom product. There are 5 expression system options: Yeast, E. coli, In Vivo Biotinylation in E. coli, Baculovirus, and Mammalian cell. Your requirements will be given top priority in determining the protein tags. For proteins within 800 aa, risk-free custom service is guaranteed. It means you will not be charged if the protein cannot be delivered.
JCAD, also known as KIAA1462, is a crucial component of endothelial cell-cell junctions [1]. JCAD has been identified as a significant gene associated with coronary artery disease (CAD) and plays a role in regulating angiogenesis [2]. JCAD is localized at cell-cell junctions in endothelial cells and has been implicated in various vascular disorders, including atherosclerosis and thrombosis [3]. JCAD has been linked to the progression of nonalcoholic steatohepatitis to liver cancer by inhibiting LATS2 kinase activity [4]. The JCAD gene has been associated with a locus on chromosome 10 and has been found to regulate Hippo signaling in endothelial cells [5][6]. Furthermore, JCAD has been reported to play a key role in atherosclerosis via shear stress mechanotransduction [7].
References:
[1] Y. Hiraoka, M. Matsumura, Y. Kakei, D. Takeda, M. Shigeoka, A. Kimotoet al., Expression of jcad and egfr in perineurial cell–cell junctions of human inferior alveolar nerve, Journal of Histochemistry & Cytochemistry, vol. 71, no. 6, p. 321-332, 2023. https://doi.org/10.1369/00221554231182193
[2] R. Li, H. Zhang, F. Tang, C. Duan, D. Liú, N. Wuet al., Coronary artery disease risk factors affected by rna modification-related genetic variants, Frontiers in Cardiovascular Medicine, vol. 9, 2022. https://doi.org/10.3389/fcvm.2022.985121
[3] L. Zhang, Jcad deficiency delayed liver regenerative repair through the hippo–yap signalling pathway, Clinical and Translational Medicine, vol. 14, no. 3, 2024. https://doi.org/10.1002/ctm2.1630
[4] J. Ye, T. Li, G. Xu, Y. Zhao, N. Zhang, J. Fanet al., Jcad promotes progression of nonalcoholic steatohepatitis to liver cancer by inhibiting lats2 kinase activity, Cancer Research, vol. 77, no. 19, p. 5287-5300, 2017. https://doi.org/10.1158/0008-5472.can-17-0229
[5] P. Jones, M. Kaiser, M. Najafabadi, S. Koplev, Y. Zhao, G. Douglaset al., jcad, a gene at the 10p11 coronary artery disease locus, regulates hippo signaling in endothelial cells, Arteriosclerosis Thrombosis and Vascular Biology, vol. 38, no. 8, p. 1711-1722, 2018. https://doi.org/10.1161/atvbaha.118.310976
[6] R. Gupta, Hippo pathway looms large for the function of the jcad (junctional protein associated with coronary artery disease) on endothelial cells, Arteriosclerosis Thrombosis and Vascular Biology, vol. 38, no. 11, p. 2546-2547, 2018. https://doi.org/10.1161/atvbaha.118.311342
[7] G. Douglas, V. Mehta, A. Zen, I. Akoumianakis, A. Goel, V. Rashbrooket al., A key role for the novel coronary artery disease gene jcad in atherosclerosis via shear stress mechanotransduction, Cardiovascular Research, vol. 116, no. 11, p. 1863-1874, 2019. https://doi.org/10.1093/cvr/cvz263
