Recombinant Human Kinesin-like protein KIF3A (KIF3A KIF3)

1. KIF3A plays an important role in epithelium apoptosis and bronchial inflammation in asthma PMID: 29156524
2. A correlation between KIF3A loss and a poorer NSCLC prognosis as well as beta-catenin and cyclin D1 upregulation further suggests that KIF3A suppresses Wnt/beta-catenin signalling and tumourigenesis in NSCLC PMID: 27596264
3. The rate of transport is set by an equilibrium between a faster state, where only kinesin family member 17 protein (KIF17) motors move the train, and a slower state, where at least one kinesin family member 3A/B protein (KIF3AB) motor on the train remains active in transport. PMID: 28761002
4. p0071 is required for directional vesicle movement and secretion of different KIF3-transported carriers, thereby regulating the transport of intracellular membrane vesicles along microtubules. PMID: 28808088
5. PLCD1 acts as a tumour suppressor, by KIF3A-mediated suppression of ERK1/2/beta-catenin/MMP7 signalling, at least in part, in breast cancer. PMID: 28423710
6. Inhibition of kif3a in the human dental follicle cells (hDFCs) and human dental pulp cells (hDPCs) is disrupted primary cilia formation and/or function, and it was shown that kif3a is important in the differentiation of hDFCs and hDPCs through the Wnt pathway. PMID: 27432616
7. High KIF3A expression is associated with glioblastoma. PMID: 26760767
8. These data suggest that GLI interactions with KIF3A-KIF3B-KAP3 complexes are essential for proper GLI transcriptional activity. PMID: 25588831
9. KIF3A and OVOL1 are involved in the development of Atopic dermatitis in the Chinese pediatric population. PMID: 26127003
10. both motor domains of KIF3A/B coordinate for processive motility and move at different speeds PMID: 15345558
11. Ablation of this phosphorylation abolished herpes simplex virus 1 US3-mediated downregulation of CD1d expression, suggesting that phosphorylation of KIF3A is the primary mechanism of viral suppression of CD1d expression. PMID: 25878107
12. Findings support the notion that upregulation of KIF3a is causal of aberrant activation of Wnt signaling in advanced prostate cancer through the KIF3a-DVL2-beta-catenin axis. PMID: 24413182
13. POPX2 affects trafficking by determining the phosphorylation status of KIF3A at serine 690. PMID: 24338362
14. Association of KIF3A, but not OVOL1 and ACTL9, with atopic eczema in Italian patients PMID: 23278845
15. in addition to its ciliogenic roles, Kif3a recruits p150(Glued) to the subdistal appendages of mother centrioles, critical for centrosomes to function as microtubule-organizing centres. PMID: 23386061
16. KIF3A is a novel candidate gene for childhood asthma PMID: 21912604
17. Our findings suggest that the KIF3A gene and/or its polymorphisms might have a susceptibility effect on aspirin-intolerant asthma (AIA). PMID: 20922562
18. Variants carried by the haplotypes of SLC22A4, SLC22A5 and KIF3A region potentially contribute to tuberculosis susceptibility among the Thai population. PMID: 20485362
19. KIF3, cilia, and nodal flow have roles in left-right determination [review] PMID: 20066075
20. Required for the normal steady-state localization of late endosomes/lysosomes but not early endosomes or recycling endosomes. PMID: 16262723
21. Interaction of KIF3A/3B with KAP3 may be important for the proper progression of mitosis. PMID: 16298999
22. We detected ALS-specific down-regulation of KIF1Bbeta and novel KIF3Abeta, two isoforms we show to be enriched in the brain, and also of SOD1, a key enzyme linked to familial ALS PMID: 17418584
23. Rip11/FIP5-kinesin-II complex plays a key role in the routing of internalized receptors through the perinuclear recycling endosomes. PMID: 18957512
24. Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion. PMID: 19043453
25. This study thus reports on transportation of KSHV viral complexes on microtubules by KIF3A PMID: 19282970

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HGNC: 6319

OMIM: 604683

KEGG: hsa:11127

STRING: 9606.ENSP00000368020

UniGene: Hs.43670