Recombinant Human Neurexin-3-beta (NRXN3), partial

1. NRXN2 may play a part in early cortical synaptogenesis, but NRXNs could have diverse roles in development including axon guidance, and intercellular communication between proliferating cells and/or migrating neurons. PMID: 28013231
2. The rare variants in NRXN3 were significantly associated with smoking status. PMID: 25450229
3. This study confirmed the genetic heterogeneity of cluster headache, suggesting that a novel rearrangement involving NRXN3 gene might be related to cluster headache in a subset of cases PMID: 24469609
4. The study showed that markers rs2217887 (NRXN3) showed weak associations. PMID: 24444492
5. a positive association between Neurexin 3 and controls in the Han Chinese population, and genetic evidence to support the susceptibility of DEACMP PMID: 24265751
6. Neurexin 3-alpha (NRXN3) is a synaptic cell-cell adhesion molecule involved in maintenance of neural connections (such as the maintenance of smoking behavior). PMID: 23909413
7. By age 7, common variations in FTO, TMEM18 and NRXN3 influence the vulnerability to metabolic complications of sleep deprivation. PMID: 22391885
8. Our findings suggested that NRXN3 might represent a major susceptibility gene for schizophrenia PMID: 23306218
9. the study finds preliminary evidence for the association of NRXN3 with Borderline Personality Disorder phenotypes. The strongest association with positive screening for BPD was found for SNP rs10083466. PMID: 23245376
10. FoxQ1 promotes glioma cell proliferation and migration by down-regulation of NRXN3 expression. PMID: 23383267
11. NRXN3 polymorphisms play a role in susceptibility to smoking behavior and are strongly implicated in human genetic vulnerability to addictive behaviors. PMID: 22716474
12. Association of the Graves disease phenotype with two markers, rs12147587 and rs2284720, located within the NRXN3 and TSHR genes, respectively. PMID: 23118423
13. N-terminal sequencing of rat neurexin III alpha provides evidence for signal peptide PMID: 9856994
14. N-terminal sequencing of cow neurexin III beta provides evidence for signal peptide PMID: 8163501
15. alpha- and gamma-secretases can sequentially process NRXN3beta, leading to the formation of two final products, an approximately 80-kDa N-terminal extracellular domain of Neurexin-3beta (sNRXN3beta) and an approximately 12-kDa C-terminal intracellular NRXN3beta domain (NRXN3beta-ICD) PMID: 21084300
16. Six NRXN3 polymorphisms were genotyped: rs983795, rs11624704, rs917906, rs1004212, rs10146997 and rs8019381 associated with impulsivity and substance abuse. PMID: 21676558
17. NRXN3 single nucleotide polymorphism rs10146997 was significantly (P = 0.0445) associated with higher risk of breast cancer development (OR = 0.66 (95% CI 0.44-0.99)). PMID: 21688152
18. Index cases of autism spectrum were clinically characterized who have rare microdeletions at 14q24.3-31.1, a region that overlaps exons of the alpha and/or beta isoforms of NRXN3. PMID: 22209245
19. Our results reveal that menopause influences the adipose tissue expression of many genes, especially of neurexin 3, metallothionein 1E, and keratyn 7, which are associated with the alteration of several key biological processes. PMID: 21358552
20. central obesity-associated variants in LYPLAL1, NRXN3, MSRA, and TFAP2B PMID: 21674055
21. Association of a polymorphism in the NRXN3 gene with the degree of smoking in schizophrenia. PMID: 19658047
22. Identification and characterization of heart-specific splicing of neurexin 3 mRNA PMID: 12379233
23. details of NRXN3's gene structure and variants, and association of NRXN3 SNPs with alcohol dependence PMID: 17804423
24. Variants in NRXN3 are associated with waist circumference, body mass index and obesity. PMID: 19557197

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HGNC: 8010

OMIM: 600567

KEGG: hsa:9369

UniGene: Hs.368307