Recombinant Human Nuclear receptor-interacting protein 1(NRIP1) ,partial

Code CSB-YP016082HU
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Source Yeast
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Code CSB-EP016082HU
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Source E.coli
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Code CSB-EP016082HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP016082HU
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Source Baculovirus
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Code CSB-MP016082HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names NRIP1
Uniprot No. P48552
Alternative Names NRIP 1; NRIP1; NRIP1_HUMAN; Nuclear factor RIP 140; Nuclear factor RIP140; Nuclear receptor interacting protein 1; Nuclear receptor-interacting protein 1; Receptor interacting protein 140; Receptor-interacting protein 140; RIP 140; RIP140
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function. Plays a role in renal development.
Gene References into Functions
  1. Data suggests that NRIP1 is overexpressed both in skin and PBMCs of psoriasis patients and may be involved in the abnormal proliferation and apoptosis of keratinocytes. PMID: 27708240
  2. In skeletal muscle, imposed rest increased NRIP1 expression by 80%, and strength training increased expression by 25% compared to baseline. Following rest, NRIP1 expression became sensitive to insulin stimulation. After re-training, NRIP1 expression decreased. Interactome analysis showed significant proximity of NRIP1 interacting partners to the obesity network/module. PMID: 28656645
  3. Taken together, these results provide new insights into the mechanism of action of LCoR and RIP140 and highlight their strong interplay for the control of gene expression and cell proliferation in breast cancer cells. PMID: 28414308
  4. Study found low expression level of RIP140 in tumor-associated macrophages (TAM) of hepatocellular carcinoma (HCC) tissues and demonstrated that RIP140 expression in plays a role in the growth of hepatoma cells. PMID: 28393222
  5. results indicated that there was a significant association between migraine and gene-gene interaction among the CYP19A1, FSHR, ESR1 and NRIP1. PMID: 27019440
  6. Data indicate that nuclear receptor interacting protein 1 (NRIP1) is elevated in tumors compared to cancer adjacent normal tissue. PMID: 26492163
  7. NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/beta-catenin pathway. PMID: 26213846
  8. NRIP1 contributes to the mitochondrial dysfunction observed in DS. Furthermore, they suggest that the NRIP1-PGC-1alpha axe might represent a potential therapeutic target for restoring altered mitochondrial function in DS. PMID: 24698981
  9. RIP140 gene has been shown to be involved in the regulation of energy expenditure, in mammary gland development and intestinal homeostasis as well as in behavior and cognition PMID: 26116758
  10. Downregulation of RIP140 promoted the tumorigenicity of HCC cells in vitro. PMID: 25391428
  11. Data suggest that vitamin D receptor target genes (NRIP1; DUSP10, dual specificity phosphatase 10; THBD, thrombomodulin; TRAK1, trafficking protein kinesin binding 1) can be used as markers for individual's response to vitamin D3 supplements. PMID: 24975273
  12. RIP140 negatively regulated the macrophage expression of ATP-binding cassette transporters A1 and G1. PMID: 25616132
  13. The associations of rs2616984 in CSMD1 gene, putative associations of rs3131296 in NOTCH4 gene, and associations of rs2229741 of NRIP1 gene with Alzheimer's disease have been found in a Russian population. PMID: 25845235
  14. data suggest that RIP140 plays an important role in ERalpha-mediated transcriptional regulation in breast cancer and response to tamoxifen treatment PMID: 25145671
  15. In breast cancer cells, GSTP1 inhibits the expression of RIP140, a negative regulator of estrogen receptor alpha transcription, at both mRNA and protein levels. PMID: 25218501
  16. RIP140 stimulated APC transcription and inhibited beta-catenin activation and target gene expression. PMID: 24667635
  17. these data demonstrate the inhibitory effects of ERbeta on estrogen signaling in ovarian cancer cells and the key role that RIP140 plays in this phenomenon. PMID: 23885094
  18. genetic association studies in population of women in Spain: Data suggest an association between an SNP in NRIP1 (rs2229741) and age at menopause; thus, duration of fertility in women may have genetic determinants involved in estrogen metabolism. PMID: 23173577
  19. Increased RIP140 level may be closely associated with inflammation and disorder of lipid and glucose metabolism in diabetic patients. PMID: 22956256
  20. RIP140, a Janus metabolic switch involved in defense functions. PMID: 23241901
  21. this work identifies the RIP140 gene as a new transcriptional target of E2F1 which may explain some of the effect of E2F1 in both cancer and metabolic diseases. PMID: 22629304
  22. Highlight the importance of cross-regulation between AhR and ERalpha and a novel mechanism by which AhR controls, through modulating the recruitment of RIP140 to ERalpha-binding sites, the kinetics and magnitude of ERalpha-mediated gene stimulation. PMID: 22071320
  23. The fusion of NRIP1 with UHRF1 involved in the unbalanced translocation between chromosomes 19 and 21 in a patient with an ALL-positive for a t(9;22) translocation. PMID: 22285022
  24. Decreased RIP140 protein content not required for exercise and AMPK-dependent increases in skeletal muscle mitochondrial content. PMID: 21700896
  25. We demonstrate that NRIP is a novel binding protein for human papillomavirus 16 (HPV-16) E2 protein and directly interacts with the TAD of HPV-16 E2. PMID: 21543494
  26. This study shows that RIP140 is a regulator of the E2F pathway, which discriminates luminal- and basal-like tumors, emphasizing the importance of these regulations for a clinical cancer phenotype. PMID: 20410059
  27. RIP140 transgenic mice, expressing increased levels of RIP140 mRNA/protein in the heart, exhibit rapid and progressive postnatal cardiomyopathy leading to premature death predominantly owing to compromised energy production. PMID: 20083575
  28. Receptor-interacting protein 140 (RIP140) is a corepressor for nuclear receptors with an important role in the inhibition of energy expenditure. PMID: 19367438
  29. Down-regulation of PROS1 gene expression by 17beta-estradiol via estrogen receptor alpha (ERalpha)-Sp1 interaction recruiting receptor-interacting protein 140 and the corepressor-HDAC3 complex. PMID: 20200160
  30. The RIP140 gene does not play a pivotal role in the process of ovulation, insulin resistance, or fat accumulation in women with PCOS. PMID: 19887821
  31. RIP140 may have a role in retinoic acid mediation of long-paced oscillations in retinoid receptor activity PMID: 19862326
  32. RIP140 has a role in binding to nuclear receptors, as well as additional functions mediated by the formation and intranuclear relocalization of a repressive protein complex PMID: 12773562
  33. there are four autonomous repression domains in the corepressor receptor interacting protein 140 PMID: 14736873
  34. RIP140 has a regulatory role in mediating anti-estrogenic effects of RA in estrogen-dependent breast cancer cells PMID: 15632153
  35. RIP140 differentially regulates ERR activity depending on the target sequence on the promoters. PMID: 16439465
  36. Receptor-interacting protein 140 is a repressor of the androgen receptor activity. PMID: 16527872
  37. RIP140 discriminates among different classes of retinoic acid target genes. RIP140 limits RA signaling & tumor-cell differentiation. RIP140 silencing sensitizes embryonal carcinoma cells to low doses of RA. PMID: 17880687
  38. The results presented here suggested the cooperative transcriptional regulation of estrogen signaling by FHL1 and RIP140. PMID: 19401155

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Subcellular Location Nucleus. Note=Localized to discrete foci and redistributes to larger nuclear domains upon binding to ligand-bound NR3C1.
Database Links

HGNC: 8001

OMIM: 602490

KEGG: hsa:8204

STRING: 9606.ENSP00000327213

UniGene: Hs.155017

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