Recombinant Human PH domain leucine-rich repeat-containing protein phosphatase 2 (PHLPP2), partial

1. DualLuciferase activity assay demonstrated that the tumor suppressor PH domain and leucine rich repeat protein phosphatase 2 (PHLPP2) was a target of miR125b, which inhibited PHLPP2 and directly bound to the 3'untranslated region of PHLPP2, resulting in elevated Akt signaling. PMID: 30226579
2. MiR-141-3p targets PHLPP2 at its 3'-untranslated region. PMID: 29738771
3. miR135a may protect human umbilical vein endothelial cell from mechanical stretch - induced injury by inhibiting PHLPP2 to activate PI3k/Akt signaling pathway. PMID: 30045018
4. TMCO1 recruited the PH domain and leucine-rich repeat protein phosphatase 2 (PHLPP2) to dephosphorylate pAKT1(serine 473) (S473). Mutagenesis at S60 of the TMCO1 protein released TMCO1-induced cell-cycle arrest and restored the AKT pathway in BFTC905 cells. Stable TMCO1 (wild-type) overexpression suppressed, whereas T33A and S60A mutants recovered, tumor size in xenograft mice. PMID: 28972042
5. Cheliensisin A (Chel A)treatment led to PH domain and Leucine rich repeat Protein Phosphatases (PHLPP2) protein degradation and subsequently increased in c-Jun phosphorylation, which could be attenuated by inhibition of autophagy mediated by Beclin 1. PMID: 27556506
6. Results show that MiR-27a directly targets PHLPP2 by binding to its 3'-UTR to inhibit its expression, and that downregulation of PHLPP2 could rescue the effect of anti-miR-27a in gastric cancer cells. PMID: 28327189
7. miR-938 promoted CRC cell proliferation by inhibiting PHLPP2 PMID: 28433657
8. two PHLPP isozymes, PHLPP1 and PHLPP2, were identified in a search for phosphatases that dephosphorylate Akt, and thus suppress growth factor signaling. PMID: 27913677
9. results identify a novel role of PHLPP in regulating aPKC and cell polarity. PMID: 27760826
10. Low PHLPP2 expression is associated with luminal breast cancer. PMID: 28224609
11. miR-3117 contributes to the proliferation of HepG2 by targeting PHLPPL. PMID: 27822662
12. Overexpression of PHLPP2 without its 3'UTR attenuated the effects of miR-181a on cell proliferation and apoptosis in keloid fibroblast cells. PMID: 27915346
13. Suggest that direct PHLPP2 downregulation is required for miR-32-induced cell proliferation of breast cancer cells. PMID: 26276160
14. Our studies not only first time identify PHLPP2 downregulation by lung carcinogen B[a]P/B[a]PDE, but also elucidate a novel molecular mechanisms underlying lung inflammation and carcinogenesis upon B[a]P/B[a]PDE exposure. PMID: 25977341
15. Results showed that PHLPP1 and PHLPP2 gene expression are down-regulated in esophageal squamous cell carcinoma. Their promotor is a target for mir-224. PMID: 26245343
16. Aberrant expression of PHLPP1 and PHLPP2 correlates with poor prognosis in patients with hypopharyngeal squamous cell carcinoma PMID: 25793736
17. miR-135a promotes cell proliferation in bladder cancer by targeting PHLPP2 and FOXO1, and is performed as an onco- PMID: 25888950
18. Data show that miR-372 modulated the expression of phosphoprotein phosphatase PHLPP2 by directly targeting its 3'-untranslated region (3'-UTR) and that miR-372 expression was inversely correlated with PHLPP2 expression in glioma samples. PMID: 25160587
19. Results reveal PHLPP2 as a new biomarker of cancer progression, and implicate it as major negative regulator of NF-kappaB signaling. PMID: 24553260
20. miR-141 and its targets PHLPP1 and PHLPP2 play critical roles in NSCLC tumorigenesis PMID: 24945731
21. biochemical characterization of phosphatase domain of PHLPP1 and PHLPP2;PHLPP1 and PHLPP2 have similar in vitro activities and respond comparably to the presence of metallic ions; metallic ions affect structural stability of the domain;identified 3 residues likely involved in metal coordination and 2 that may be important for structural integrity PMID: 24892992
22. This study reveals functional and mechanistic links between miRNA-224 and the tumor suppressors PHLPP1 and PHLPP2 in the pathogenesis of colorectal cancer PMID: 23846336
23. IGF-1 may exert its proliferative effects by negatively regulating the PTEN/PHLPP2 signaling pathway in CM cells. PMID: 23715723
24. Low PHLPP2 expression is associated with malignant phenotypes in non-small cell lung cancer. PMID: 23856247
25. Diacylglycerol signaling limits Akt activation through diacylglycerol kinase delta and PHLPP2. PMID: 23184957
26. PHLPP1 and PHLPP2 have an effect on retinal rod CNG channel sensitivity. PMID: 22183406
27. Knockdown of PHLPP1 or PHLPP2 resulted in an increase in S6K1 phosphorylation. PMID: 21986499
28. The PHLPP2 dephosphorylate Mst1 on the T387 inhibitory site, which activate Mst1 and its downstream effectors p38 and JNK to induce apoptosis. PMID: 20513427
29. A functional polymorphism that impairs the activity of PHLPP2 and correlates with elevated Akt phosphorylation and increased PKC levels, was identified. PMID: 19324870

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HGNC: 29149

OMIM: 611066

KEGG: hsa:23035

STRING: 9606.ENSP00000348611

UniGene: Hs.709458