Recombinant Human Peroxisomal multifunctional enzyme type 2(HSD17B4)

Code CSB-YP010774HU
Product Type Recombinant Protein
Size US$2010
Uniprot No. P51659
Relevance Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Storage Buffer Tris-based buffer,50% glycerol
Alias 17-beta-hydroxysteroid dehydrogenase 4 Short name: 17-beta-HSD 4 D-bifunctional protein Short name: DBP Multifunctional protein 2 Short name: MPF-2 Short chain dehydrogenase/reductase family 8C member 1 Cleaved into the following 2 chains: (3R)-hydroxyacyl-CoA dehydrogenase (EC:1.1.1.n12) Enoyl-CoA hydratase 2 (EC:4.2.1.107, EC:4.2.1.119) Alternative name(s): 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase
Species Homo sapiens (Human)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence MGSPLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRRGGKAVANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIHRVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIEGRKSNIHCNTIAPNAGSRMTQTVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWERTLGAIVRQKNHPMTPEAVKANWKKICDFENASKPQSIQESTGSIIEVLSKIDSEGGVSANHTSRATSTATSGFAGAIGQKLPPFSYAYTELEAIMYALGVGASIKDPKDLKFIYEGSSDFSCLPTFGVIIGQKSMMGGGLAEIPGLSINFAKVLHGEQYLELYKPLPRAGKLKCEAVVADVLDKGSGVVIIMDVYSYSEKELICHNQFSLFLVGSGGFGGKRTSDKVKVAVAIPNRPPDAVLTDTTSLNQAALYRLSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSARRVLQQFADNDVSRFKAIKARFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISNAYVDLAPTSGTSAKTPSEGGKLQSTFVFEEIGRRLKDIGPEVVKKVNAVFEWHITKGGNIGAKWTIDLKSGSGKVYQGPAKGAADTTIILSDEDFMEVVLGKLDPQKAFFSGRLKARGNIMLSQKLQMILKDYAKL
Research Area Cancer
Source Yeast
Gene Names HSD17B4
Protein Names Recommended name: Peroxisomal multifunctional enzyme type 2 Short name= MFE-2 Alternative name(s): 17-beta-hydroxysteroid dehydrogenase 4 Short name= 17-beta-HSD 4 D-bifunctional protein Short name= DBP Multifunctional
Expression Region 1-736aa
Tag Info N-terminal 6xHis-tagged
Mol. Weight 81.7kDa
Protein Description Full Length
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids.
Involvement in disease D-bifunctional protein deficiency (DBPD); Perrault syndrome 1 (PRLTS1)
Subcellular Location Peroxisome
Protein Families Short-chain dehydrogenases/reductases (SDR) family
Tissue Specificity Present in many tissues with highest concentrations in liver, heart, prostate and testis.
Database Links

HGNC: 5213

OMIM: 233400

KEGG: hsa:3295

STRING: 9606.ENSP00000420914

UniGene: Hs.406861

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