Recombinant Human Pigment epithelium-derived factor (SERPINF1)

Code CSB-YP021084HU
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Source Yeast
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Code CSB-EP021084HU
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Source E.coli
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Code CSB-EP021084HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP021084HU
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Source Baculovirus
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Code CSB-MP021084HU
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Source Mammalian cell
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Product Details

>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
Cell proliferation-inducing gene 35 protein; EPC 1; EPC-1; EPC1; OI12; OI6; PEDF; PEDF_HUMAN; PIG 35; PIG35; Pigment epithelium derived factor; Pigment epithelium-derived factor; Proliferation inducing protein 35; Serine (or cysteine) proteinase inhibitor; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; Serpin F1; Serpin family F member 1; Serpin peptidase inhibitor; Serpin peptidase inhibitor clade F member 1; serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; SERPINF 1; Serpinf1
Homo sapiens (Human)
Expression Region
Target Protein Sequence
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Please contact us to get it.

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Target Background

Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
Gene References into Functions
  1. Findings confirm that both M1- and M2-like macrophages are essential for retinal neovascularization and uncover a vital protective role of PEDF against retinal neovascularization by regulating macrophage recruitment and polarization. PMID: 28211523
  2. results suggest that PEDF act as a multipotent factor in the skin and the imbalance of PEDF and VEGF may be responsible for the transformation from normal skin to psoriasis. PMID: 29579411
  3. expression unaltered in preterm prelabor rupture of the membranes (pRPOM) or after exposure to risk factors of pPROM PMID: 28562170
  4. Data found novel mutations of the SERPINF1 and FKBP10 genes in Chinese families with autosomal recessive osteogenesis imperfecta PMID: 29512769
  5. Study showed that plasma PEDF levels were significantly lower in CAD patients than in controls. PMID: 29574467
  6. The T-C haplotype frequency of rs1136287-rs1894286 in PEDF were significantly correlated to the increased susceptibility to age-related macular degeneration(AMD). The rs1136287 polymorphism in PEDF may be related to the occurrence risk of AMD. Additionally, a haplotype is also a non-ignorable risk factor. PMID: 30142832
  7. this study is the first to demonstrate that PEDF promotes HUCMSC proliferation and protects them from apoptosis by reducing p53 expression in the serum-free medium. This study provides crucial information for clinical-scale expansion of human umbilical cord mesenchymal stem cells . PMID: 29244789
  8. Results show that the levels of miR-9, PEDF and VEGF are increased with diabetic nephropathy (DN) progression. miR-9, VEGF and PEDF are independent risk factors of DN. PMID: 28667418
  9. Results suggested that the pigment epithelium-derived factor (PEDF)/vascular endothelial growth factor (VEGF) ratio played a pivotal role in the spontaneous regression of infantile hemangioma (IH). PMID: 29664206
  10. In this study, folate receptor alpha (FRa)-targeted nano-liposomes (FLP) were designed to enhance the anti-tumor effect by targeting delivery of exogenous PEDF gene to cervical cancer cells..These results clearly showed that FLP were desired carriers for PEDF gene and FLP/PEDF might represent a potential novel strategy for gene therapy of cervical cancer. PMID: 27576898
  11. Plasma PEDF and RBP4 identified Insulin resistance in subjects with no prior diagnosis of diabetes. PMID: 28648555
  12. results demonstrate a novel functional role of PEDF/LR axis in driving metastasis through ERK1/2-mediated EMT in hepatocellular carcinoma (HCC) and provided a promising prognostic marker in HCC. PMID: 28771223
  13. PN-1 and PEDF share structural and functional features, and expression patterns in the retina. PMID: 28706437
  14. by inhibiting the phosphorylation of VEGFR2, the P18 peptide ( functional fragment of pigment epithelial-derived factor (PEDF)modulates signalling transduction between VEGF/VEGFR2 and suppresses activation of the PI3K/Akt cascades, leading to an increase in mitochondrial-mediated apoptosis and anti-angiogenic activity. PMID: 28627623
  15. Using AFM to image where exogenous hPEDF bound in rabbit femur, findings demonstrate that PEDF binds heterogeneously in cortical rabbit femur. Exogenous PEDF binding was concentrated at areas between microstructures with highly aligned collagen fibrils. Binding was not observed on or within the collagen fibrils themselves. PMID: 28602715
  16. PEDF was acutely regulated by a glucose load and was correlated with BMI but not with diabetes. PMID: 28399539
  17. The findings indicate that PEDF functions as a tumor-suppressor gene in the occurrence of epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma. PMID: 28569772
  18. the T allele of rs8075977 in the 5'-flanking region of the PEDF gene may be protective for Coronary Artery Disease PMID: 28420811
  19. PEDF exacerbates cartilage degeneration in an age-dependent manner under inflammatory conditions. PMID: 28122611
  20. the trophoblast-derived anti-angiogenic molecule PEDF is involved in restricting growth and expansion of the feto-placental endothelium predominantly in late pregnancy and targets to modulate the intracellular effect of VEGF PMID: 27278471
  21. Mutations in SERPINF1 result in osteogenesis imperfecta Type VI PMID: 27796462
  22. Expression of GLUT1 is stimulated by hyperglycemia and low oxygen supply, and this overexpression was associated with increased activity of GLUT1 in the cell membrane that contributes to the impairment of the RPE secretory function of PEDF. PMID: 27440994
  23. Serum levels of PEDF were significantly correlated with body mass index, vasodilation and brachial artery intima-media thickness. PMID: 27716557
  24. PEDF expression in retinal endothelial cells plays a key role in modulation of cell proliferation, migration, and capillary morphogenesis. PMID: 28747334
  25. study found that PEDF binds to the C1q head regions and activates the classical complement pathway; in addition, observed that in synovial fluid (SF) from rheumatoid arthritis patients, PEDF forms detectable complexes with C4d, which are present in a range of concentrations; SF from nonarthritic donors consistently contained little or no C4d-PEDF complexes PMID: 28637898
  26. PEDF is a hormone-regulated negative autocrine mediator of endometrial proliferation. PMID: 28911166
  27. Findings suggest that PEDF plays a critical role in preventing hypoxia/reoxygenation injury by modulating anti-oxidant and anti-apoptotic factors and promoting autophagy. PMID: 27219009
  28. PEDF is associated with increased epithelial-mesenchymal transition in bladder cancer PMID: 27644257
  29. Six rare heterozygous SERPINF1 variants were found in seven patients in our familial otosclerosis cohort; three are missense mutations predicted to be deleterious to protein function PMID: 27056980
  30. Excessive amount of PEDF50 in myopic specimens have been shown to correlate with the abrogated PEDF processing rather than with an increase of its expression. Moreover, immunohistochemical staining of the myopic Tenon's capsule tissue sections revealed the halo of deposited PEDF50 in the fibroblast extracellular space. PMID: 27590659
  31. Wnt/beta-catenin pathway may mediate ox-LDL-induced endothelial injury via oxidative stress, and PEDF ameliorates endothelial injury by suppressing Wnt/beta-catenin pathway and subsequently reducing oxidative stress. PMID: 28173817
  32. Furthermore, pigment epithelium-derived factor (PEDF), a secreted glycoprotein known for its anti-tumor properties, blocked Wnt3a-directed induction of autophagy proteins. Autophagy inhibition was complemented by reciprocal regulation of the oxidative stress enzymes, superoxide dismutase 2 (SOD2) and catalase. PMID: 27557659
  33. The results indicated that the reduction of VEGF and increase in PEDF are causative to the evolution of infantile hemangioma. PEDF may play a key role in the spontaneous regression of infantile hemangioma and may become an important potential therapeutic agent for infantile hemangioma. PMID: 28197761
  34. results demonstrate that PEDF maintains tumor-suppressive functions in fibroblasts to prevent CAF conversion and illustrate the mechanisms by which melanoma cells silence stromal PEDF to promote malignancy PMID: 26921338
  35. The changes in the SERPINH1 and SERPINF1 genes in patients with osteogenesis imperfect were synonymous polymorphisms or missense changes located in non-coding regions. PMID: 27706701
  36. The present data provided evidence that reducing C3 activation can decreases VEGF and increase PEDF mRNA level in retinal pigment epithelial cells. PMID: 27747237
  37. PEDF represents a marker for transient cartilage during all neonatal and postnatal developmental stages and promotes the termination of cartilage tissue by upregulation of matrix-degrading factors and downregulation of cartilage-specific genes. PMID: 28191465
  38. we report on two apparently unrelated children with OI type VI who had the same unusual homozygous variant in intron 6 of SERPINF1 PMID: 26815784
  39. We confirmed that expression of SERPINF1 in the liver restored the serum level of PEDF. We also demonstrated that PEDF secreted from the liver was biologically active by showing the expected metabolic effects of increased adiposity and impaired glucose tolerance in Serpinf1(-/-) mice. PMID: 26693895
  40. Study demonstrated the inhibitory effect of PEDF on insulin-dependent molecular mechanisms of glucose homeostasis, and suggests that PEDF could be a specific target in the management of metabolic disorders. PMID: 26700654
  41. Study discuss the anti-tumor activities of PEDF and focus on its dual role as an inhibitor (e.g., angiogenesis) and as an inducer of various vital biological processes that lead to the therapeutic effect via different mechanisms of action. [review] PMID: 26746675
  42. hCG-induced PEDF downregulation and VEGF upregulation are mediated by similar signaling cascades emphasizes the delicate regulation of ovarian angiogenesis. PMID: 26612427
  43. We demonstrate that rPEDF may serve as a useful intervention to alleviate the risk of tamoxifen-induced endometrial pathologies PMID: 26450919
  44. We showed that transplantation of pigment epithelial cells overexpressing PEDF can restore a permissive subretinal environment for RPE and photoreceptor maintenance, while inhibiting choroidal blood vessel growth. PMID: 26697494
  45. plasma PEDF similar in type 2 diabetes mellitus and obese groups of children PMID: 25293868
  46. We conclude that under OGD condition, PEDF and 44mer reduce H9c2 cells apoptosis and inhibit OGD-induced oxidative stress via its receptor PEDF-R and the PPARgamma signaling pathway. PMID: 26966066
  47. Thus PEDF could be involved in the establishment of the avascular nature of seminiferous tubules and after puberty androgens may further reinforce this feature. PMID: 26333415
  48. PEDF binds VEGFR-1 and VEGFR-2 in vascular endothelial cells. PMID: 25948043
  49. Studies indicate that pigment epithelium-derived factor (PEDF) is a natural protein of the retina . PMID: 26427478
  50. PEDF sustained glioma stem cell self-renewal by Notch1 cleavage. PMID: 25992628

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Involvement in disease
Osteogenesis imperfecta 6 (OI6)
Subcellular Location
Secreted. Melanosome. Note=Enriched in stage I melanosomes.
Protein Families
Serpin family
Tissue Specificity
Retinal pigment epithelial cells and blood plasma.
Database Links

HGNC: 8824

OMIM: 172860

KEGG: hsa:5176

STRING: 9606.ENSP00000254722

UniGene: Hs.532768

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