Product Details

Purity

Greater than 90% as determined by SDS-PAGE.

Target Names

PLXNA4

Uniprot No.

Q9HCM2

Alternative Names

FAYV2820; KIAA1550; PLEXA4; Plexin-A4; PlexinA4; PLXA4_HUMAN; plxna4; PLXNA4A; PLXNA4B; PRO34003; UNQ2820/PRO34003

Species

Homo sapiens (Human)

Source

E.coli

Expression Region

25-521aa

Target Protein Sequence

LLTRQPAPLSQKQRSFVTFRGEPAEGFNHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPLTTTNNVNKMLLIDYKENRLIACGSLYQGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVSYSNLDDKLFIATAVDGKPEYFPTISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIYYVYGFSSGNFVYFLTLQPEMVSPPGSTTKEQVYTSKLVRLCKEDTAFNSYVEVPIGCERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESALCIFILKQINDRIKERLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSDMVRGIPVFTEDRDRMTSVIAYVYKNHSLAFVGTKSGKLKKSFGTGPQGGITQEWIGVEGDPPGANIASQEQMLCVYLQCSSHKAISDQRVQPLLCCFLNVPGNS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Mol. Weight

60.0kDa

Protein Length

partial of Isoform 3

Tag Info

N-terminal 6xHis-tagged

Form

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

3-7 business days

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet & COA

Please contact us to get it.

Description

The expression region of this recombinant Human PLXNA4 covers amino acids 25-521. The theoretical molecular weight of the PLXNA4 protein is 60 kDa. The PLXNA4 protein was expressed in e.coli. The N-terminal 6xHis tag was fused into the coding gene segment of PLXNA4, making it easier to detect and purify the PLXNA4 recombinant protein in the later stages of expression and purification.

Human Plexin-A4 (PLXNA4) is a transmembrane receptor protein that belongs to the plexin family. PLXNA4 plays a crucial role in axon guidance during neural development. It interacts with semaphorins, a family of proteins that mediate repulsive axon guidance cues. Through its signaling activities, PLXNA4 influences neuronal migration and connectivity. Beyond the nervous system, PLXNA4 is also implicated in cancer progression, angiogenesis, and immune responses. The intricate functions of PLXNA4 in various physiological and pathological processes make it a subject of interest in neuroscience, oncology, and immunology research, offering insights into potential therapeutic targets.

Target Background

Function

Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.

Gene References into Functions

Both CLU and PLXNA4 have been genetically associated with Alzheimer disease (AD) risk and our data thus provide a direct relationship between two AD risk genes. Our data suggest that increasing the levels of PLXNA4 or targeting CLU-PLXNA4 interactions may have therapeutic value in AD. PMID: 27378688
There is a significant association between Alzheimer's disease risk and SNPs in PLXNA4. PMID: 25043464
Rare variants in PLXNA4 and Parkinson's disease. PMID: 24244438
Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF and bFGF signaling. PMID: 21832283

Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Protein Families

Plexin family

Database Links

HGNC: 9102

OMIM: 604280

KEGG: hsa:91584

STRING: 9606.ENSP00000323194

UniGene: Hs.511454

Code	CSB-EP862071HU
Abbreviation	Recombinant Human PLXNA4 protein, partial
MSDS	MSDS Datasheet
Size	$224
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Image	(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Recombinant Human Plexin-A4 (PLXNA4), partial

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