Recombinant Human Plexin-D1 (PLXND1 KIAA0620)

1. the receptor Plexin-D1 contains a sorting motif that interacts with the adaptor protein GIPC1 to facilitate transport to recycling endosomes. PMID: 28224988
2. SNPs associated with type 2 diabetes and obesity may also increase the risk of developing gestational diabetes mellitus (GDM) in the Chinese population. Among these SNPs, we report for the first time that rs945508 in ARHGEF11, rs10804591 in PLXND1 and rs10245353 in NFE2L3 were associated with GDM. PMID: 28554271
3. Authors found that the PlexinD1 cleavage product binds to actin rods, pathological aggregate-like structures which had so far been described for age-related neurodegenerative diseases. Data suggest a novel disease mechanism for SMA involving formation of actin rods as a molecular sink for a cleaved PlexinD1 fragment leading to dysregulation of receptor signaling. PMID: 29016853
4. Plexin D1 plays a role in collagen contraction in human lung fibroblasts. PMID: 26648031
5. Findings suggest that Plexin-D1/class III semaphorin (Sema3E) axis is triggered in systemic sclerosis (SSc) endothelium. PMID: 26292963
6. finding that PLXND1 and REV3L mutations are responsible for a proportion of MBS patients suggests that de novo mutations in other genes might account for other MBS patients PMID: 26068067
7. The data indicate that Plexin-D1 operates in a cell context-specific fashion, mediating different synaptogenic outcomes depending upon neuron type. PMID: 25976775
8. Plxnd1 is a novel regulator of VAT growth, body fat distribution, and insulin sensitivity in both zebrafish and humans PMID: 25831505
9. The identification and characterization of SH3BP1 as a novel downstream effector of Sema3E-PlexinD1 provides an explanation for how extracellular signals are translated into cytoskeletal changes and unique cell behavior. PMID: 24841563
10. It is therefore suggested that SEMA3C signaling, propagated through the heterodimer receptor plexin-D1/neuropilin, is important for truncus arteriosus septation PMID: 24254849
11. A critical role of Sema3E/Plexin D1 interaction in tumor resistance to apoptosis. PMID: 24139859
12. Strong expression of plexD1 was detected in endothelial cells of cervical cancer samples, yet no expression was seen in endothelial cells of normal cervical tissues, which suggests a potential role of PlexD1 in cervical cancer-associated angiogenesis PMID: 22738647
13. analysis of Sema3E/plexin-D1 mediated epithelial-to-mesenchymal transition in ovarian endometrioid cancer PMID: 21559368
14. a novel phospholipid-regulated antiangiogenic signaling pathway whereby Sema3E activates Arf6 through Plexin-D1 and consequently controls integrin-mediated endothelial cell attachment to the extracellular matrix and migration. PMID: 21795701
15. Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice PMID: 21505259
16. Semaphorin 3E-Plexin D1 signaling in cancer cells is crucially implicated in their metastatic behavior and may therefore be a promising target for strategies aimed at blocking tumor metastasis. PMID: 20664171
17. Sema3E acts on plexin D1 to initiate a two-pronged mechanism involving R-Ras inactivation and Arf6 stimulation, which affect the status of activation of integrins and their intracellular trafficking, respectively. PMID: 20385769
18. Results of extensive mutational analysis leads to the exclusion of the PLEXIN-D1 gene as the causative gene in Mobius syndrome 2, and in isolated Mobius syndrome. PMID: 15301830
19. These results show that PLXND1 expression during tumor development is strongly correlated with both invasive behavior and metastasis, but exclude Sema3E as an activating ligand. PMID: 18974298
20. Plexin D1 is abundantly expressed on tumor vasculature and malignant cells in the primary and metastatic tumors. PMID: 19703316

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HGNC: 9107

OMIM: 604282

KEGG: hsa:23129

STRING: 9606.ENSP00000317128

UniGene: Hs.301685