Recombinant Human Protein HEXIM1 (HEXIM1)

1. The 7SK RNA binds to Hexim1 and turns it into an inhibitor of the positive transcription elongation factor (P-TEFb). And in addition to its action on P-TEFb, it plays a role in a variety of different mechanisms: it controls the stability of transcription factor components and assists binding of transcription factors to their targets. PMID: 29345523
2. We conclude that the degradation of NPM1 and HEXIM1 through autophagy in certain AML subsets contributes to the activation of the BET pathway in these cells. PMID: 27732946
3. Identify a HEXIM1-containing ribonuclear protein complex composed also of DNA-PK, paraspeckle subunits, and the long non-coding RNA (lncRNA) NEAT1, which acts as a key nuclear regulator of DNA-mediated activation of innate immune response through the cGAS-STING pathway. PMID: 28712728
4. HMBA and derivative HMBA4a1 induce HEXIM1 activity, targeting several signaling pathways critical in tumorigenesis and metastasis. PMID: 27238569
5. HSP70 activator shows similar activity as HMBA and 4a1 to induce HEXIM1 expression, suggesting that HMBA and 4a1 might be putative HSP70 activators PMID: 28213333
6. Our results demonstrated that HEXIM1 exhibited the most consistent response to BET inhibitors in all of the settings examined, including tumors and surrogate tissues. PMID: 27903752
7. Suggest that greater tumor associated macrophage density, strong Hexim1 expression, strong SMAD2 expression, and mild SMAD7 expression play important roles in the progression of prostate adenocarcinoma. PMID: 26608417
8. Results show that HEXIM1 is a tumor suppressor in melanoma that responds to nucleotide stress by inhibiting transcription elongation of tumorigenic genes and stabilizing mRNA transcripts of other tumor suppressor genes. PMID: 27058786
9. Data indicate the binding of RNA-binding protein HEXIM with 7SKsnRNP complex comprising the non-coding RNA 7SK and proteins MePCE and LARP7. PMID: 25863285
10. PPM1G phosphatase directly binds 7SK RNA and the kinase inhibitor Hexim1 once P-TEFb has been released from the 7SK snRNP. PMID: 26324325
11. This study demonstrates a novel role of HEXIM1 in regulating human pluripotent stem cells fate through a P-TEFb-independent pathway. PMID: 23977357
12. HEXIM1 functions as an AR (androgen receptor) co-repressor as it physically interacts with the AR and is required for the ability of anti-androgens to inhibit androgen-induced target gene expression and cell proliferation. PMID: 24844355
13. the release of P-TEFb from the 7SK snRNP led to increased synthesis of HEXIM1 but not HEXIM2 PMID: 24515107
14. There is evidence for a direct interaction between HIF-1alpha and HEXIM1, and HEXIM1 up-regulated hydroxylation of HIF-1alpha. PMID: 24015760
15. P-TEFb/HEXIM1-dependent transcriptional regulation may play a pathophysiological role in RVH and be a novel therapeutic target for mitigating RVH in PAH PMID: 23300697
16. results not only identify HEXIM1 as a positive regulator of p53, but also propose a novel molecular mechanism of p53 activation caused by the anti-cancer drugs and compounds. PMID: 22948151
17. Changes in Hexim-1 protein expression and cellular distribution significantly influence androgen receptor activation and transforming growth factor (TGF)-beta signaling in prostate cancer progression. PMID: 22095517
18. N-terminal residues in cyclin T1 are specifically involved in the binding of cyclin T1 to HEXIM1 but not to Tat. PMID: 22342181
19. Structural insights were provided into the recognition of the regulator protein Hexim1 by P-TEFb and the modulation of coiledcoil dynamics by specific discontinuities. PMID: 22033481
20. Tat efficiently replaces HEXIM1 on the 7SK snRNA in vivo and it promotes the disassembly of the 7SK/HEXIM/P-TEFb negative transcriptional regulatory snRNP to augment the nuclear level of active P-TEFb. PMID: 20976203
21. reincorporation of HEXIM1 into the 7SK snRNP is likely the regulated step of reassembly of the 7SK snRNP containing P-TEFb PMID: 20808803
22. data provide evidence to suggest a novel role for HEXIM1 in cancer progression PMID: 20453883
23. T-loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P-TEFb function and exchange between the Brd4 and 7SK/HEXIM1 regulatory complexes. PMID: 20201073
24. binding to Cyclin T1 induces an asymmetry or sterical hindrance in the first coiled coil segment of dimeric Hexim1 that disallows formation of a 2:2 complex. PMID: 20210365
25. MAQ1 cooperates with 7SK RNA to form a novel type of CDK inhibitor. PMID: 12832472
26. Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFB (CDK9/cyclin T) inhibitor. PMID: 15201869
27. HEXIM1 and HEXIM2 exhibit distinct expression patterns in various human tissues PMID: 15713661
28. utilization of HEXIM1 or HEXIM2 to bind and inhibit P-TEFb can be differentially regulated in vivo. PMID: 15713662
29. Hexim1 has a cyclin T-binding domain and binds competitively to HIV-1 Tat PMID: 15855166
30. increased estrogen down regulated gene 1 expression results in inhibition of cyclin T1 recruitment and estrogen receptor 1 DNA binding PMID: 15940264
31. HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b. PMID: 15941832
32. HEXIM1 dimer associates with only one molecule of RNA. PMID: 15965233
33. HIV-1 Tat transactivation is effectively inhibited by co-expression of HEXIM1; HEXIM1 expression specifically represses transcription mediated by the direct activation of P-TEFb through artificial recruitment of GAL4-CycT1 PMID: 15992410
34. analysis of positive transcription elongation factor - HEXIM1 - 7SK RNA complex PMID: 15994294
35. Ectopic expression of HEXIM1 causes growth inhibition and promotes neuronal differentiation. These findings highlight a crucial role of HEXIM1 protein during cell differentiation. PMID: 16222702
36. the interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct its binding to P-TEFb and subcellular localization that culminates in the inhibition of transcription PMID: 16362050
37. Binding of HEXIM1 is a prerequisite for association of P-TEFb with the G302-C324 apical region of the 3' hairpin of 7SK that is highly reminiscent of the human immunodeficiency virus transactivation-responsive RNA. PMID: 16382153
38. Data show that the transcription-dependent dissociation of P-TEFb-HEXIM1-7SK RNA relies upon formation of hnRNP-7SK RNA complexes. PMID: 17709395
39. provide structural insights how Hexim1 recognizes the Cyclin T1 subunit of positive transcription elongation factor b PMID: 17724342
40. a mutant HEXIM1 protein that cannot be phosphorylated and released from P-TEFb and 7SK snRNA via the PI3K/Akt pathway antagonizes this HMBA-mediated induction of viral production. PMID: 17937499
41. NPM binds to HEXIM1 in vitro and in vivo, and functions as a negative regulator of HEXIM1. PMID: 18371977
42. HEXIM1 may act as a gene-selective transcriptional regulator via direct interaction with certain transcriptional regulators including glucocorticoid receptor. PMID: 18407829
43. HEXIM1 regulation on estrogen action showed a decrease in estrogen-stimulated recruitment of ERalpha, P-TEFb, and S2P RNAP II to promoter and coding regions of ERalpha-responsive genes pS2 and CCND1 with increased HEXIM1 expression in MCF-7 cells PMID: 18757415
44. HEXIM1 may participate in tissue-selective determination of glucocorticoid sensitivity via direct interaction with GR at least in certain gene sets including atp1a1 and scnn1a. PMID: 18801933
45. Ubiquitination of HEXIM1 protein increases the inhibitory ability of HEXIM1 protein on P-TEFb-dependent transcription, but does not lead to proteasome-dependent protein degradation of HEXIM1. PMID: 19617712
46. The tripartite protein-RNA complex formation between Hexim, Cyclin T and 7SK snRNA, was analyzed. PMID: 19883659
47. Biochemically characterized a hexamethylene bisacetamide-inducible protein HEXIM1, which is a novel nuclear protein. Interacts with p50 of NF-kB and suppresses NF-kB transcription. PMID: 12581153

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HGNC: 24953

OMIM: 607328

KEGG: hsa:10614

STRING: 9606.ENSP00000328773

UniGene: Hs.586945