Recombinant Human Protein NLRC5(NLRC5) ,partial

Code CSB-YP771457HU
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Source Yeast
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Code CSB-EP771457HU
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Source E.coli
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Code CSB-EP771457HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP771457HU
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Source Baculovirus
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Code CSB-MP771457HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names NLRC5
Uniprot No. Q86WI3
Alternative Names Caterpiller protein 16.1; CLR16.1; FLJ21709; FLJ39711; NLR family, CARD domain containing 5; NLR family, CARD-containing 5; NLR family, caspase recruitment domain-containing 5; NLRC5; NLRC5_HUMAN; NOD-like receptor C5; NOD27; NOD4; Nucleotide-binding oligomerization domain protein 27; Nucleotide-binding oligomerization domain protein 4; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 5 ; nucleotide-binding oligomerization domains 27; OTTHUMP00000164675; Protein Caterpiller 16.1; Protein NLRC5
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms.
Gene References into Functions
  1. Genetic polymorphisms in NLRC5 may be used as prognostic markers of survival of colorectal cancer patients, as well as for survival in response to 5-FU treatment. PMID: 29762254
  2. knockdown of NLRC5 attenuates renal ischemia/reperfusion injury in vitro through the activation of PI3K/Akt signaling pathway. PMID: 29655162
  3. NLRC5 may act as a key mediator in renal fibroblast activation and fibrogenesis PMID: 29608899
  4. obtained 18 pair-wise interactions within and between the NLRC5 ad PD-L1 genes and 6 more when IFNGR variants were added PMID: 29408916
  5. Our study, for the first time, identified the possible involvement of a polymorphism within NLRC5 gene as a possible biomarker for periodontitis condition susceptibility among Italian individuals from genetic isolates. PMID: 28122660
  6. NLRC5 interacts with miR-34a.NLRC5 role in HPV16 persistence. PMID: 27423514
  7. These results demonstrate that NLRC5 promotes hepatocellular carcinoma progression via the AKT/VEGF-A signaling pathway PMID: 27338800
  8. NLRC5 not only positively correlates with the increase of beta-catenin but also coordinates the activation of downstream Wnt/beta-catenin signaling pathway, regulating cell proliferation, migration and invasion in hepatocellular carcinoma. PMID: 26975630
  9. silencing NLRC5 reduced extracellular matrix expression in keloid fibroblasts through inhibiting the TGF-beta1/Smad signaling pathway. PMID: 27525969
  10. CITA/NLRC5 and CIITA are transcriptional regulators that orchestrate the concerted expression of critical components in the MHC class I and class II pathways, respectively. [review] PMID: 27087581
  11. NLRC5 expression was significantly associated with the activation of CD8(+) cytotoxic T cells and patient survival in multiple cancer types. Thus, NLRC5 constitutes a novel prognostic biomarker and potential therapeutic target of cancers. PMID: 27162338
  12. NLRC5 regulates TGFB1-induced proliferation and activation of hepatic stellate cells during hepatic fibrosis. PMID: 26592197
  13. In a transformed cell line, NLRC5 plays a significant role in IL-6 and IL-1Beta secretion. PMID: 25820389
  14. NLRC5 function is shaped by reversible ubiquitination, which modulates the NF-kappaB activation switch PMID: 26620909
  15. RSV infection of lung epithelial cells induces expression of RIG-I, NLRC5, and subsequent upregulation of HLA-A, HLA-B and HLA-C. PMID: 25972545
  16. a novel role for NLRC5 in RIG-I-mediated antiviral host responses against influenza virus infection, distinguished from the role of NLRC5 in MHC class I gene regulation. PMID: 25404059
  17. This study presents a detailed functional study of the domains of NLRC5 revealing that the N-terminal domain of human NLRC5 has intrinsic transcriptional activity. PMID: 25127861
  18. Unusual structural features revealed by the solution NMR structure of the NLRC5 caspase recruitment domain. PMID: 24815518
  19. A model for full-length human NLRC5 was prepared and, besides the closed conformation of monomeric NLRC5, a heptameric platform was also modeled for the opened conformational NLRC5 monomers. PMID: 24044430
  20. rhinovirus ion channel protein 2B triggers NLRP3 and NLRC5 inflammasome activation and IL-1beta secretion in bronchial cells PMID: 23815151
  21. Expression of NLRC5 positively correlates with histocompatibility class I expression in human tissues. PMID: 22490867
  22. NLRC5 can cooperate with X1 box-binding transcription factor RFX and X2 box-binding transcription factor ATF1 in activation of histocompatibility class I promoter region. PMID: 22490869
  23. NLRC5 acts as a key transcriptional regulator of MHC I in lymphocytes and support an essential role for NLRs in directing not only innate but also adaptive immune responses. PMID: 22412192
  24. NLRC5-mediated MHC class I gene induction requires an intact nuclear localization signal and nuclear distribution of NLRC5. PMID: 22310711
  25. NLRC5 was proposed to function as a positive and as a negative regulator of IFN, NF-kappaB, AP-1 signaling and antiviral immunity. (Review) PMID: 22024701
  26. NLRC5 is a critical component of inflammasome-dependent interleukin (IL)-1beta secretion in response to a repertoire of stimuli that also activate NLRP3. PMID: 21191067
  27. function for NLRC5 in anti-viral innate immune responses PMID: 20538593
  28. NLRC5 is identified and characterized as a key regulator of proinflammatory pathways in immune cells. PMID: 20610642
  29. suggest that NLRC5 is a transcriptional regulator, orchestrating the concerted expression of critical components in the MHC class I pathway. PMID: 20639463
  30. Study identifies NLRC5 as a negative regulator that blocks two central components of the NF-kappaB and type I interferon signaling pathways and suggest an important role for NLRC5 in homeostatic control of innate immunity. PMID: 20434986
  31. NLRC5 may represent a molecular switch of interferon (IFN)-gamma activation sequence and IFN-specific response element signaling pathways contributing to antiviral defense mechanisms. PMID: 20061403

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Subcellular Location Cytoplasm.
Protein Families NLRP family
Tissue Specificity Expressed in spleen, thymus, lung, brain, tonsil, heart and prostate.
Database Links

HGNC: 29933

OMIM: 613537

KEGG: hsa:84166

STRING: 9606.ENSP00000262510

UniGene: Hs.528836

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