Recombinant Human Ribonuclease pancreatic (RNASE1)

1. Data suggest that ribonuclease inhibitor (RNH1) protects HeLa cells from ribonuclease 1 (RNase 1). PMID: 27806571
2. Focusing on the increase in an N-glycosylated Asn residue of serum pancreatic ribonuclease 1, specifically Asn(88), affords a new diagnostic marker for pancreatic cancer PMID: 25336120
3. Deletion of five residues in the hinge loop of pancreatic ribonuclease induces formation of a domain-swapped dimer that leads to the generation of linear aggregates of pancreatic RNase, revealed by the crystal packing. PMID: 24100329
4. The reduced conformational flexibility of eosinophil cationic protein can be dynamically and functionally reproduced in the RNase A scaffold. PMID: 23135272
5. The nuclear transport of PE5 is critical for its cytotoxicity. PMID: 20352290
6. The role on the dimerization process of different residues of a domain-swapped dimer human pancreatic ribonuclease variant. PMID: 21767499
7. In human pancreatic ribonuclease both glutamine 28 and arginine 39 are important for the cleavage of dsRNA. PMID: 21408145
8. Vascular RNase1 and RNase5 are mainly produced by vascular endothelial cells and can serve, depending on the vascular bed, different functions in vascular homeostasis and endothelial cell responses. PMID: 21103661
9. Studies illustrate of the making dimeric pancreatic RNase through removal by directed mutagenesis of most of the N-terminal alpha-helix to the remainder of the protein. PMID: 19156888
10. Human endothelial cells selectively express large amounts of pancreatic-type ribonuclease (RNase 1) PMID: 12210760
11. Results show that Glycine 38 is crucial for the full catalytic activity of the human enzyme on duplex RNA as its substitution with aspartate or alanine results in a drastic reduction in the dsRNA cleavage activity of HPR. PMID: 12237131
12. Results reveal the dendritic cell-activating activity of pancreatic ribonuclease and suggest that it is a likely participant of inflammatory and immune responses--an endogenous multifunctional immune alarmin. PMID: 15528350
13. Altogether the results suggest that the pressure-folding transition state of ribonuclease A looks like a collapsed globule with some secondary structure and a weakened hydrophobic core. This is the first direct comparison using a set of mutants. PMID: 16597833
14. RNase-1 has ribonuclease H activity. PMID: 16738129
15. Human pancreatic-ribonuclease interacts with importin alpha through different basic residues, including Lys1 and the arginine clusters 31-33 and 89-91. PMID: 16780873
16. The results were confirmed at the level of mRNA and protein, and suggested that four genes (OPCML, RNASE1, YES1 and ACK1) could play a key role in the tumorigenesis and metastasis of gastric cancer. PMID: 17109515
17. Structural and energetic aspects of the interaction between human RI (hRI) and human pancreatic ribonuclease (RNase 1), is reported. PMID: 17350650
18. Coulombic forces mediate extracellular and intracellular equilibria in a dichotomous manner that both endangers cells and defends them from the potentially lethal enzymatic activity of ribonucleases. PMID: 17705507
19. irrespective of differences in ethnic groups, RNASE1 might show markedly low heterogeneity in its genetic structure with regard to these SNPs PMID: 18219569
20. Multiple side chain conformations observed for key surface residues are proposed to be crucial for membrane binding as well as translocation and efficient RNA hydrolysis. PMID: 18495155

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HGNC: 10044

OMIM: 180440

KEGG: hsa:6035

STRING: 9606.ENSP00000344193

UniGene: Hs.78224