Recombinant Human S-methyl-5'-thioadenosine phosphorylase(MTAP)

Code CSB-YP622639HU
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Source Yeast
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Code CSB-EP622639HU
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Source E.coli
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Code CSB-EP622639HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP622639HU
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Source Baculovirus
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Code CSB-MP622639HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names MTAP
Uniprot No. Q13126
Alternative Names 5' methylthioadenosine phosphorylase; 5''-methylthioadenosine phosphorylase; BDMF; c86fus; DMSFH; DMSMFH; Epididymis luminal protein 249; HEL 249; LGMBF; MeSAdo phosphorylase; Methylthioadenosine phosphorylase; MSAP; MTA phosphorylase; MTAP; MTAP_HUMAN; MTAPase; S methyl 5 thioadenosine phosphorylase; S methyl 5' thioadenosine phosphorylase; S-methyl-5''-thioadenosine phosphorylase
Species Homo sapiens (Human)
Expression Region 1-283
Protein Length full length protein
Tag Info The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Gene References into Functions
  1. melanoma risk alleles correlate with an allele-specific hyper-methylation and down-regulation of gene expression PMID: 27761950
  2. The obtained data suggested a negative association between copy number variation of the MEAP genes and Atherothrombotic stroke. PMID: 28477716
  3. High MTAP expression is associated with prostate cancer. PMID: 26910893
  4. Results indicate complex rearrangements involving CDKN2A locus and frequent occurrence of fusion transcripts involving methylthioadenosine phosphorylase (MTAP) and ANRIL genes. PMID: 26909863
  5. The SNP rs7023954 of methylthioadenosine phosphorylase co-dominantly expressed alleles revealed no difference in the conversion rate of 5'-methylthioadenosine to adenine and 5-methylthioribose-1-phosphate, indicating that this known enzymatic activity does not modulate the tumor suppressive function of methylthioadenosine phosphorylase. PMID: 27479139
  6. Data demonstrate that MTAP deficiency leads to accumulation of MTA inducing deregulation of central cellular pathways that control cell fate and contributes to the onset of a proliferative and antiapoptotic phenotype in the liver. PMID: 26819315
  7. methionine adenosyltransferase II alpha (MAT2A), and the arginine methyltransferase, PRMT5, as vulnerable enzymes in cells with MTAP deletion. PMID: 27068473
  8. MTAP expression was significantly higher in Luminal-A breast tumors than in triple negative breast neoplasms, suggesting the lack of expression in more aggressive breast tumors. PMID: 26751376
  9. study to describe MTAP expression in a series of Pilocytic astrocytomas and relate it to the clinicopathological features of the patients; found MTAP expression is retained in Pilocytic astrocytomas and is not an outcome predictor for these tumors PMID: 26088413
  10. MTAP deficiency was predictive of worse disease-specific survival and distant metastasis-free survival, suggesting its role in disease progression and as an independent prognostic biomarker of nasopharyngeal carcinoma PMID: 26656376
  11. In the MTAP-deficient cases, the homozygous deletion of MTAP predicted adverse outcome. In MTAP-deficient cells, MTAP reexpression inhibited cell migration and invasion, proliferation and anchorage-independent colony formation and downregulated cyclin D1. PMID: 25426549
  12. MTAP expression is an independent prognostic factor and has greater prognostic significance than p16 expression in non-small cell lung cancer and concordant loss of MTAP and p16 expression indicates poor outcomes in lung cancer patients. PMID: 24969958
  13. MTAP-mediated regulation of methylthioadenosine links polyamine metabolism with NF-kappaB activation and apoptosis in hepatic stellate cells. PMID: 24324622
  14. SNP rs10118757 was associated with CAD risk in a Chinese Han population, indicating that MTAP gene may play a potential role in the pathophysiological process of CAD. PMID: 23462334
  15. Homozygous deletion of MTAP gene is associated with haploid lymphoblastic leukemia. PMID: 23508829
  16. Authors report here that a high percentage of t-cell lymphoma lack the enzyme methylthioadenosine phosphorylase (MTAP). PMID: 23040436
  17. MTAP gene might be involved in the etiology of myocardial infarction in Chinese Han ethnicity. PMID: 20302706
  18. Letter: inactivation of MTAP expression seems to be an important step in the development and progression of malignant melanoma. of PMID: 23000879
  19. Data indicate that a signature of seven biomarkers (Bax, Bcl-X, PTEN, COX-2, beta-Catenin, MTAP and CD20) was found to be an independent negative predictor for overall and recurrence-free survival in cutaneous malignant melanoma (MM). PMID: 22685558
  20. A large negative heat capacity change of -600 cal/(mol K) upon inhibitor binding to MTAP is consistent with altered hydrophobic interactions and release of water. PMID: 21985704
  21. Polymorphisms in nevus-associated genes MTAP is associated with invasive cutaneous melanoma. PMID: 21962134
  22. The present study suggests that MTAP plays an important role in the regulation of gastric carcinogenesis. PMID: 21412930
  23. Expression of MTAP is significantly higher in human colorectal cancer than in normal colorectal tissues. Demethylation of MTAP promoter may play an important role in up-regulating MTAP expression. PMID: 19622299
  24. The expression of MTAP protein in non-small cell lung cancer tissue was significantly lower than that in paracarcinomous tissue and borderline lung tissue. PMID: 21342647
  25. MTAP deficiency results in accumulation of 5'-deoxy-5'-methylthioadenosine, which is associated with increased tumorigenicity. PMID: 21356366
  26. CDKN2B (p15(INK4b)), CDKN2A (p16(INK4a), p14(ARF)), and MTAP are abundantly expressed in atherosclerotic lesions. PMID: 20637465
  27. MTDIA antitumor activity in xenografts supports MTAP as a target for lung cancer therapy. PMID: 21135097
  28. Single nucleotide polymorphism in MTAP gene is associated with nevi. PMID: 20574843
  29. Detection of CDKN2A-MTAP co-deletion in peritoneal mesotheliomas can help identify those patients who may have an unfavorable outcome PMID: 20081810
  30. MTAP homozygous deletion, the predominant mechanism to deplete protein expression, is present in 17% of gastrointestinal stromal tumors PMID: 19887491
  31. Methylthioadenosine phosphorylase, a gene frequently codeleted with p16(cdkN2a/ARF), acts as a tumor suppressor in a breast cancer cell line. PMID: 12438261
  32. Results suggest an important role of methylthioadenosine phosphorylase inactivation in the development of melanomas. PMID: 12875987
  33. Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites PMID: 14506228
  34. MTAP is not expressed in normal human colonic epithelium but is strongly upregulated in colon carcinoma. PMID: 15492751
  35. epigenetic mechanisms, involving DNA methylation and histone deacetylation, may play a role in the silencing of MTAP gene expression in hepatocarcinoma PMID: 15511635
  36. MTAP activity is frequently lost, and ODC activity is frequently elevated in both pancreatic adenocarcinoma and neuroendocrine tumors PMID: 15534104
  37. MTAP expression is lost in approximately 30% of infiltrating pancreatic cancers and in a lower percentage of other periampullary neoplasms; loss is a result of homozygous deletions encompassing both the MTAP and p16INK4A/CDKN2A genes PMID: 15662124
  38. Results demonstrated concordant loss of MTAP and p16 protein expression in pancreatic intraepithelial neoplasia. PMID: 15832197
  39. MTAP inactivation is associated with hepatocellular carcinoma development and invasiveness PMID: 16081515
  40. Selective loss at the 3' end of MTAP was observed in head and neck squamous cell carcinoma cell line UMSCC-11A. PMID: 16618910
  41. The frequency of Methylthioadenosine phosphorylase (MTAP) deletions in conventional, grade II chondrosarcomas by fluorescence in situ hybridization (FISH) analysis was investigated. PMID: 16631464
  42. Methylthioadenosine phosphorylase (MTAP) gene deletion and lack of protein expression are associated with poor prognosis in mantle cell lymphoma. PMID: 16778103
  43. Regulation of MTAP by reactive oxygen species might participate in the redox regulation of the methionine catabolic pathway in the liver PMID: 18237276
  44. analysis of methylthioadenosine phosphorylase (MTAP) deficiency in non-small cell lung carcinoma PMID: 18555557
  45. This study demonstrates for the first time that polymorphisms in CDKN2B and MTAP gene may influence the risk of myocardial infarction in Chinese. PMID: 19272367
  46. The G allele of rs10118757 was associated with an increased risk of stroke in Han Chinese even after controlling for confounding factors. The GA+GG genotype was associated with the increased risk of an undetermined subtype of ischemic stroke. PMID: 19427650

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Involvement in disease Diaphyseal medullary stenosis with malignant fibrous histiocytoma (DMSMFH)
Subcellular Location Cytoplasm, Nucleus
Protein Families PNP/MTAP phosphorylase family, MTAP subfamily
Tissue Specificity Ubiquitously expressed.
Database Links

HGNC: 7413

OMIM: 112250

KEGG: hsa:4507

STRING: 9606.ENSP00000369519

UniGene: Hs.193268


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