Recombinant Human SNW domain-containing protein 1 (SNW1)

1. c-Abl promotes TGF-beta-induced SKIP/Smad3 interaction. PMID: 28666867
2. Higher SKIP expression is associated with poor prognosis in malignant pleural mesothelioma PMID: 27543864
3. Upon step 1 catalysis, Cwc25 contacts with the branch-site region, and enhanced crosslinks of Prp8 and Prp45 with nucleotides surrounding the branch-site were observed. PMID: 26393790
4. Rab1A regulates anterograde melanosome transport by recruiting kinesin-1 to melanosomes through interaction with SKIP PMID: 25649263
5. Results show that SNW1 directly associates with EFTUD2 and SNRNP200 and that disruption of SNW1 association with these proteins promotes the apoptosis of breast cancer cells. PMID: 25450007
6. A transcriptome-wide analysis revealed that SNW1 or PRPF8 depletion affects the splicing of specific introns in a subset of pre-mRNAs, including pre-mRNAs encoding the cohesion protein sororin and the APC/C subunit APC2. PMID: 25257309
7. SKIP overexpression is involved in the pathogenesis of breast cancer. PMID: 24150787
8. High SKIP expression was detected in clinical HCC samples. PMID: 23696020
9. SKIP increased 5alpha-dihydrotestosterone (DHT) induced N-terminal/C-terminal AR interaction from 12-fold to almost 300-fold in a two-hybrid assay, and enhanced AR ligand-independent AF-1 transactivation. PMID: 23566155
10. Arl8 and SKIP are required for lysosomes to distribute away from the microtubule-organizing center. We identify two kinesin light chain binding motifs in SKIP that are required for lysosomes to accumulate kinesin-1 and redistribute to the cell periphery. PMID: 22172677
11. SKIP is required for epithelial mesenchymal transition and invasiveness induced by TGF-beta1 in transformed cells. PMID: 20965173
12. This suggests that transcription of stress response genes, unlike, e.g., the SNW1-sensitive mitosis-specific genes, can proceed uncoupled from regulators that normally function under physiological conditions. PMID: 21461980
13. molecular model for the binding mode of SKIP to PPIL1 which emphasizes the versatility of cyclophilin-type PPIases to engage in additional interactions with other proteins apart from active site contacts despite their limited surface area. PMID: 20368803
14. SKIP is essential for p53 stress-induced expression of the p21 PMID: 21460037
15. The large disordered region in SKIP provides an interaction platform. Its disorder-order transition, induced by PPIL1 binding, may adapt the requirement for a large structural rearrangement occurred in the activation of spliceosome PMID: 20007319
16. SIRT1 associates with SKI-interacting protein (SKIP) and modulates its activity as a coactivator of retinoic acid receptor. PMID: 19934264
17. may couple vitamin D receptor-mediated transcription and RNA splicing PMID: 12840015
18. These results show that the human SKIP gene can functionally substitute for the mRNA splicing gene PRP45 of S. cerevisiae. PMID: 15194481
19. SKIIP plays independent roles in transcription elongation and pre-mRNA splicing. PMID: 15905409
20. SKIP binds with CHES1 in a region within the final 66 hydrophobic residues, and thus defining a new protein-protein interaction domain of SKIP. PMID: 16102918
21. SifA, SKIP, SseJ, and RhoA family GTPases cooperatively promote host membrane tubulation. PMID: 18996344
22. SKIP acts with c-Myc and Menin to promote HIV-1 Tat:P-TEFb transcription at an elongation step that is bypassed under stress. PMID: 19818711

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HGNC: 16696

OMIM: 603055

KEGG: hsa:22938

STRING: 9606.ENSP00000261531

UniGene: Hs.445498