Recombinant Human Solute carrier family 17 member 9 (SLC17A9), partial

Code CSB-YP880141HU
MSDS
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Source Yeast
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Code CSB-EP880141HU
MSDS
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Source E.coli
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Code CSB-EP880141HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP880141HU
MSDS
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Source Baculovirus
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Code CSB-MP880141HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
SLC17A9
Uniprot No.
Alternative Names
C20orf59; S17A9_HUMAN; Slc17a9; Solute carrier family 17 (vesicular nucleotide transporter) member 9; Solute carrier family 17 member 9; VNUT
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Involved in vesicular storage and exocytosis of ATP. May accumulate ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles.
Gene References into Functions
  1. Results identified SLC17A9 as another pathogenic gene for DSAP, which suggests a correlation between the aberrant vesicular nucleotide transporter and the pathogenesis of DSAP. PMID: 25180256
  2. data suggest that SLC17A9 activity mediates lysosomal ATP accumulation and plays an important role in lysosomal physiology and cell viability. PMID: 24962569
  3. It is suggested that the functions of VNUT, in addition to P2 receptors may be a target for anti-inflammatory response in skin. PMID: 24292772
  4. These results suggest that SLC17A9 is the relevant nucleotide transporter responsible for the uptake of cytosolic nucleotides into mucin granules. PMID: 23467297
  5. the existence of an SLC17A9-dependent ATP-enriched vesicular pool in biliary epithelium that undergoes regulated exocytosis to initiate purinergic signaling. PMID: 21613220
  6. analysis of involvement of SLC17A9-dependent vesicular exocytosis in the mechanism of ATP release during T cell activation PMID: 20382737
  7. SLC17A9 protein acts as a vesicular nucleotide transporter (VNUT) and plays an essential role in vesicular storage of ATP in the ATP-secreting cells [SLC17A9] PMID: 18375752

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Involvement in disease
Porokeratosis 8, disseminated superficial actinic type (POROK8)
Subcellular Location
Membrane; Multi-pass membrane protein.
Protein Families
Major facilitator superfamily, Sodium/anion cotransporter family
Tissue Specificity
Predominantly expressed in adrenal gland, brain and thyroid.
Database Links

HGNC: 16192

OMIM: 612107

KEGG: hsa:63910

STRING: 9606.ENSP00000359376

UniGene: Hs.512686

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