Recombinant Human Succinate-semialdehyde dehydrogenase, mitochondrial(ALDH5A1)

Code CSB-EP001577HU
Product Type Recombinant Protein
Size US$1726
Uniprot No. P51649
Relevance Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Storage Buffer Tris-based buffer,50% glycerol
Alias Aldehyde dehydrogenase family 5 member A1; A1NAD(+)-dependent succinic semialdehyde dehydrogenase
Species Homo sapiens (Human)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence AGRLAGLSAALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCYGGL
Research Area Metabolism
Source E.coli
Gene Names ALDH5A1
Expression Region 48-535aa
Tag Info N-terminal 6xHis-SUMO-tagged
Mol. Weight 68.3kDa
Protein Description Full Length of Mature Protein
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
Involvement in disease Succinic semialdehyde dehydrogenase deficiency (SSADHD)
Subcellular Location Mitochondrion
Protein Families Aldehyde dehydrogenase family
Tissue Specificity Brain, pancreas, heart, liver, skeletal muscle and kidney. Lower in placenta.
Database Links

HGNC: 408

OMIM: 271980

KEGG: hsa:7915

STRING: 9606.ENSP00000314649

UniGene: Hs.371723

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