Recombinant Human Sulfate transporter (SLC26A2), partial

1. Two heterozygous mutations in SLC26A2 mutations occur in a three-generational family with cases of multiple epiphyseal dysplasias. PMID: 29024831
2. Results show that SLC26A2 expression is high in numerous tumor types and, provide evidence that it downregulates the TRAIL receptors, DR4 and DR5 which confers resistance to TRAIL. PMID: 28108622
3. slc26a2 is to be a critical otic gene whose dysfunction may induce hearing impairment PMID: 26375458
4. findings provide the first identification of autosomal dominant SLC26A2 mutations in patients with dysplastic spondylolysis, suggesting a new clinical entity in the pathogenesis of chondrodysplasia involving lumbosacral spine PMID: 26077908
5. Diastrophic dysplasia sulfate transporter (SLC26A2) is expressed in the adrenal cortex and regulates aldosterone secretion. PMID: 24591336
6. Up-regulation of SLC26A2 is associated with colorectal cancer. PMID: 24222123
7. A compound heterozygote SLC26A2 mutation is associated with robin sequence, mild limbs shortness, accelerated carpal ossification, and multiple epiphysial dysplasia PMID: 23840040
8. SLC13A4 and SLC26A2 were the most abundant sulfate transporter mRNAs, which localized to syncytiotrophoblast and cytotrophoblast cells, respectively. PMID: 23453247
9. 73% of autosomal-recessive multiple epiphyseal dysplasia patients were either homozygous, or compound heterozygous, for SLC26A2 mutations. PMID: 21922596
10. Solute carrier family 26 member a2 (Slc26a2) protein functions as an electroneutral SOFormula/OH-/Cl- exchanger regulated b PMID: 22190686
11. Mutations in the SLC26A2 gene causes diastrophic dysplasia. PMID: 21155763
12. Analysis suggests that, while the DTDST family of disorders contains at least seven different conditions, gene mutations appear to cause a phenotypic continuum. DTDST genotype alone is an imperfect predictor of clinical severity along this continuum. PMID: 21077202
13. New intermediate phenotype between MED and DD caused by compound heterozygous mutations in the DTDST gene is reported. PMID: 21077204
14. Characterize transport of oxalate and sulfate by human SLC26A2 and mouse Slc26a2 expressed in Xenopus oocytes. PMID: 20219950
15. Diminished DTDST expression through epigenetic silencing is associated with colon cancer. PMID: 20460514
16. DTDST function is crucial for the uptake of extracellular sulfate required for proteoglycan sulfation. PMID: 14692227
17. The effects of sulfur availablility on proteoglycan sulfation in mice transgenic for a mutation of this gene are reported. PMID: 16719839
18. This study found an association between single nucleotide polymorphisms of the SLC26A2 gene and juvenile idiopathic arthritis. PMID: 17393463
19. DTDST is upregulated by dexamethasone stimulation of HT1080 fibrosarcoma cells and is required for fibronectin (FN) extracellular matrix deposition by these cells. PMID: 18056413
20. A novel SLC26A2 mutation was found in all subjects, inserted by site-directed mutagenesis in a vector harbouring the SLC26A2 cDNA, and expressed in sulfate transport deficient Chinese hamster ovary (CHO) cells to measure sulfate uptake activity PMID: 18708426

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HGNC: 10994

OMIM: 222600

KEGG: hsa:1836

STRING: 9606.ENSP00000286298

UniGene: Hs.302738