Recombinant Human Taste receptor type 2 member 38 (TAS2R38)

1. bitter taste perception TAS2R38 diplotypes associated with vegetable consumption in participants enrolled in either an enhanced or a minimal nutrition counseling intervention, were examined. PMID: 29686110
2. A QPCR analysis demonstrated that TAS2R38, a subtype of the bitter taste receptor, was associated with GLP-1 secretion. Berberine-mediated GLP-1 secretion was attenuated in response to small interfering RNA silencing of TAS2R38. PMID: 29363059
3. genetic association studies in population of preschool-aged children in Guelph, Ontario: Data suggest that SNPs in CD36 (rs1761667), TAS1R2 (rs35874116), and TAS2R38 (rs713598) are associated with snacking behavior in the population studied. [PILOT PROJECTS] PMID: 29385734
4. genetic association studies in population in Italy: Data suggest that an SNP in TAS2R38 (RS713598) is associated with higher bitter taste perception threshold and higher/lower preferences for selected nutrient/energy dense foods, such as beer, butter, and cured meat; this SNP may be associated with overweight. PMID: 28738701
5. The current study suggests that genetic variation in TAS2R38 and CA6 influences picky eating in preschoolers. PMID: 28858874
6. this study demonstrated that a Bacillus cereus product(s) elicited an NO-mediated innate defense response in upper airway epithelium that seemed to be partially mediated by a T2R signaling pathway PMID: 28716170
7. Findings suggest that TAS2R38 may be associated with the risk for gastric cancer in Koreans, although the TAS2R38 diplotype did not influence dietary intake. PMID: 27245112
8. It is suggested that the risk and resistance of cancers is antagonistically controlled by the two TAS2R38 alleles, PAV and AVI, rather than by the AVI allele alone. PMID: 28552880
9. In addition, we found signatures of ancient selective forces acting on different African TAS2R38 haplotypes. Collectively our results provide evidence for a relaxation of recent selective forces acting on this gene and a revised hypothesis for the origins of the present-day worldwide distribution of TAS2R38 haplotypes. PMID: 27138342
10. genetic association studies in population of elderly women in Poland: Data suggest that SNPs in TAS2R38 (rs713598, rs1726866, rs10246939) and an SNP in CA6 (rs2274333) are associated with intake of and preferences for some foods (coffee and white cabbage) among the population studied. (TAS2R38 = taste receptor type 2 member 38; CA6 = carbonic anhydrase VI) PMID: 28455260
11. Despite many other factors influencing food preference and intake in children, actual intake of sweet food items is associated with TAS2R38 genotype. Children with PP or PA genotype consume more (energy dense) sweet tasting foods. PMID: 27475756
12. We now describe expression of T2R38 in tumor cells in patients with pancreatic cancer and in tumor-derived cell lines. our data indicate a new, additional function of the taste receptor T2R38 beyond sensing "bitter". PMID: 26862855
13. TAS2R38 gene has an impact on phenotypic and clinical outputs affecting obesity, showing significant associations with extreme weight conditions, and changes in both olfactory capacity and immune traits. PMID: 27059147
14. This research is the first to demonstrate a relationship between T2R38 bitter taste receptor activity (assessed by phenylthiocarbamide taste sensitivity), a genetic trait, and in vitro biofilm formation in clinical isolates recovered from chronic rhinosinusitis patients PMID: 27309535
15. T2R38 is thus much more broadly tuned for bacterial compounds than previously thought. PMID: 28902853
16. TAS2R38 genotype and 6-n-propylthiouracil sensitivity status revealed high percentage of non-tasters. Food preferences and BMI did not significantly correlate TAS2R38 genotype. PMID: 28652185
17. T2R38 is stimulated by acyl-homoserine lactones, gram-negative quorum-sensing molecules, and subsequently activates nitric oxide-dependent innate immune responses. The formation of mature cilia is necessary for T2R38 expression and function, and polymorphisms that underlie T2R38 functionality appear to be involved in susceptibility to upper respiratory infection and recalcitrant CRS. PMID: 27650657
18. Genetic Variation in the TAS2R38 PMID: 27711175
19. Immunohistochemistry of human ileum tissues was performed in this study, which showed that TAS2R38 was co-localized with glucagon-like peptide 1 (GLP-1) in enteroendocrine L-cells. PMID: 27208775
20. Study did not find an association between TAS2R38 genotype and chronic rhinosinusitis (CRS), thus questioning its real contribution to CRS susceptibility. PMID: 27515546
21. The expression of TAS2R38 in placental tissues points to further new functions and hitherto unknown endogenous ligands of TAS2Rs far beyond bitter tasting. PMID: 26950109
22. Our investigation indicates that T2R38 genotype correlates both with SNOT-22 scores and rhinologic-specific quality of life in DeltaF508 homozygous cystic fibrosis patients PMID: 26678226
23. Variability in perceived bitterness of capsaicin and ethanol were significantly associated with TAS2R38 PMID: 26785164
24. This study suggest that: 1) alexithymia, in addition to the TAS2R38 polymorphism, may play a role in responsiveness to the aversive and bitter taste of PROP; and 2) alexithymia. PMID: 26805725
25. phagocytes are activated via a rather specialized receptor that was not previously described on myeloid cells, the bitter taste receptor T2R38. PMID: 26782143
26. TAS2R38 genotype predicts surgical outcome in nonpolypoid chronic rhinosinusitis. PMID: 26562612
27. This study finding significant excess of rare nonsynonymous variants exclusive to European Americans smokers in TAS2R38. PMID: 25450229
28. T2R38 is expressed in distinct populations of enteroendocrine cells in the human colonic mucosa. It colocalized with CCK-, GLP1- or PYY-IR. There were more T2R38-positive cells in overweight/obese subjects. PMID: 26866366
29. The novel TAS2R38 AVV haplotype was associated with alcohol intake in Mexican-Mestizo population. PMID: 26256902
30. Our analyses revealed also, besides simple associations, complex associations of bitterness sensitivity across TAS2R PMID: 26406243
31. dental plaque amount, lactobacilli count, age, and saliva buffer capacity, as well as TAS2R38 gene polymorphism, explained total of 87.8% of variations in DMFT scores. PMID: 26377569
32. Our data suggest that the regulation of gingival innate immunity by T2R38 is genotype-dependent PMID: 26552761
33. Study demonstrates that the response profiles of the cat bitter receptors Tas2r38 and Tas2r43 are distinct from those of their orthologous human receptors PMID: 26037485
34. A strong correlation between the two matrices was found suggesting that the pattern of food liking was closely related to the distribution of PROP phenotype . same relationship was not observed when TAS2R38 genotypes were substituted for PROP phenotype PMID: 24626196
35. Expression and functional activity of the bitter taste receptors TAS2R1 and TAS2R38 in human keratinocytes PMID: 25573083
36. A significant effect modification of the PROP(6-n-propylthiouracil)-taste intensity relationships by TAS2R38 diplotype was observed. PMID: 25634331
37. Study showed that PROP (6-n-propylthiouracil) bitterness was due to TAS2R38 diplotypes, whereas the density of fungiform papillae was more closely associated with gustin genotypes PMID: 25447475
38. The hTAS2R38 genotype may have distinct associations with food consumption in boys and girls. PMID: 24912558
39. Genetic variation in TRPV1 and TAS2Rs influence sensations from sampled EtOH and may potentially influence how individuals initially respond to alcoholic beverages. PMID: 25257701
40. All psychophysical data were subsequently analyzed as a function of TAS2R38 genotype. PMID: 23761681
41. genetic polymorphism is associated with chronic rhinosinusitis in Canadien patients PMID: 24415641
42. genetic variation in TAS2R38 is related to individual body composition measures and may further influence consumer goods intake in the Sorbs possibly via individual sensitivity to bitter taste. PMID: 24312479
43. genetic association studies in African and Asian Americans in New York City: Data (from studies using 6-n-propylthiouracil taste intensity as biomarker) suggest that genetic variation in TAS2R38 is not associated with overweight in populations studied. PMID: 24418005
44. Gustin and TAS2R38 genotypes were associated with PROP threshold, but bitterness intensity was mostly determined by TAS2R38 genotypes. PMID: 24040192
45. results provide evidence that PAV-taste receptor type 2 member 38 (TAS2R38) expression amount correlates with individual differences in bitter sensory perception and diet PMID: 24025627
46. Evaluated the phenotypic variations at TAS2R38 gene locus in relation to PMS severity and adiposity measures among adult women. PMID: 23980393
47. PTC (phenylthiocarbamide) / PROP (6-n-propylthiouracil)-nontaster TAS2R38 genotype/haplotype was associated with height and weight but not with BMI, which may in turn have influenced the energy and carbohydrate intakes. PMID: 23535535
48. genetic polymorphism is associated with chronic rhinosinusitis disease progression, necessity foe surgery and surgical outcome PMID: 23322450
49. the TAS2R38 genotypes of schizophrenia patients was examined to determine whether the increased prevalence of nontasters in this patient population was indicative of a specific genetic association PMID: 22955840
50. The localization of TAS2R38 is neither restricted to the cell surface nor particularly enriched at the level of the microvilli. PMID: 22792271

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HGNC: 9584

OMIM: 171200

KEGG: hsa:5726

STRING: 9606.ENSP00000448219

UniGene: Hs.647085