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Recombinant Human Tectonin beta-propeller repeat-containing protein 2 (TECPR2), partial

Recombinant Human Tectonin beta-propeller repeat-containing protein 2 (TECPR2), partial

Code	CSB-YP023369HU
MSDS	MSDS
Size	Pls inquire
Source	Yeast
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Code	CSB-EP023369HU
MSDS	MSDS
Size	Pls inquire
Source	E.coli
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Code	CSB-EP023369HU-B
MSDS	MSDS
Size	Pls inquire
Source	E.coli
Conjugate	Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code	CSB-BP023369HU
MSDS	MSDS
Size	Pls inquire
Source	Baculovirus
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Code	CSB-MP023369HU
MSDS	MSDS
Size	Pls inquire
Source	Mammalian cell
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Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

TECPR2

Uniprot No.

O15040

Alternative Names

TECPR2; KIAA0297; KIAA0329; Tectonin beta-propeller repeat-containing protein 2; WD repeat-containing protein KIAA0329/KIAA0297

Species

Homo sapiens (Human)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Customer Reviews and Q&A

■ Customer Reviews

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■ Q&A

For this target, we're interested in full length instead of partial. Can you check to see if you can provide this full-length protein? We are interested in 50 ug.

Thanks for your inquiry. The reference link of this protein: https://www.uniprot.org/uniprot/O15040
This full length protein contains 1411aa, which is very difficult to express, the success rate will be much lower even if we agree to have a try, and it's not risk-free.
We can provide custom service if you want to have a try, however as its length is over 800aa, we will charge step by step. The minimum size for EP/YP is 1mg and for BP/MP is 100ug.
If we can successfully express this protein, we will charge some fees accordingly and provide the purified protein.
If we are failed in expressing this protein, you need to pay some fees for the gene synthesis and subcloning, and we will provide the constructed plasmid and strains.
PS: The expression plasmid is not for sale if this project is successful.

Target Background

Function

Probably plays a role as positive regulator of autophagy.

Gene References into Functions

Whole exome sequencing in an Italian pedigree suggests involvement of TECPR2 in a complex form of progressive motor neuron disease. PMID: 27406698
The discovery of additional TECPR2 utations in non-Bukharian patients implies that this disease might be more common than previously appreciated PMID: 26542466
Results show that TECPR2 associates with several trafficking components as SEC24D and cooperates with LC3C to regulate ER exit sites and ER export suggesting that TECPR2 functions as molecular scaffold linking early secretion pathway and autophagy. PMID: 26431026
The discovered TECPR2 mutation implicates autophagy, a central intracellular mechanism, in spastic paraparesis. PMID: 23176824

Involvement in disease

Spastic paraplegia 49, autosomal recessive (SPG49)

Protein Families

WD repeat KIAA0329 family

Tissue Specificity

Detected in skin fibroblast (at protein level).

Database Links

HGNC: 19957

OMIM: 615000

KEGG: hsa:9895

STRING: 9606.ENSP00000352510

UniGene: Hs.195667