Recombinant Human Transforming growth factor beta-1-induced transcript 1 protein (TGFB1I1)

1. this paper shows that IL-17-driven intestinal fibrosis is inhibited by Itch-mediated ubiquitination of HIC-5 PMID: 28612841
2. Here we show genome-wide that blocked GBR generally require CHD9 and BRM for GR occupancy in contrast to GBR that are not blocked by Hic-5. Hic-5 blocked GBR are enriched near Hic-5 blocked GR target genes but not near GR target genes that are not blocked by Hic-5. PMID: 29738565
3. Isolated Hic-5(-/-);PyMT CAFs were defective in stress fiber organization and exhibited reduced contractility. These cells also failed to efficiently deposit and organize the ECM in two and three dimensions. This, in turn, impacted three-dimensional MDA-MB-231 tumor cell migration behavior PMID: 27893716
4. Hic-5 regulates GR binding site selection by a novel mechanism, exploiting gene-specific requirements for chromatin remodeling enzymes to selectively influence DNA occupancy and gene regulation by a transcription factor. PMID: 28381557
5. As aging increased, more ARA55 were expressed in PZ stromal cells, leading to more sensitive androgen/androgen receptor (AR) signal pathway, then constituting a more feasible environment to cancer cells. PMID: 27178620
6. Hic-5 appears to enhance complex formation between MT1-MMP and FAK in activated endothelial cells, which likely coordinates matrix proteolysis and cell motility. PMID: 26769900
7. Hic-5 plays a central role in the positive feedback ROS-JNK signaling cascade that regulates hepatocellular carcinoma progression. PMID: 26416447
8. Hic-5 influences the genomic occupancy of multiple steroid receptors and thereby blocks some aspects of hormonal regulation. PMID: 25763609
9. Endothelial Hic-5 plays an important role in the formation of microvilli-like structures and in the interaction between ECs and monocytes, leading to monocyte recruitment and subsequent development of atherosclerosis. PMID: 25587044
10. Studies in vitro and in vivo using TGF-beta1 and TGFB1I1 shRNA demonstrated that TGFB1I1 is required for TGF-beta stimulated EMT that contributes to malignant progression of astrocytomas. PMID: 25333259
11. Hic-5 siRNA also suppressed TGF-beta2-induced fibrogenic activity and dexamethasone-induced myocilin expression in HTM cells. PMID: 26313302
12. Hic5 coordinates AR signaling with adhesion and extracellular matrix contacts to regulate cell behavior in the tumor microenvironment. PMID: 24440747
13. Hic-5 suppresses senescence and profibrotic activities of myofibroblasts by down-regulating Nox4 expression. PMID: 24831009
14. The ubiquitin ligase activity of Cbl-c by the direct interaction of the LIM zinc coordinating domain of Hic5 is demonstrated. PMID: 23145173
15. Hic-5 can potentially exercise multiple functions in growth, differentiation, migration and adhesion of keratinocytes, partially via nuclear-cell membrane shuttling. PMID: 23062781
16. the HIC-5- and KLF4-dependent mechanism transactivates p21(Cip1) in response to anchorage loss PMID: 23007394
17. It plays a roll in extracellular matrix remodeling and the signal transduction via reactive oxygen species. (review) PMID: 22712231
18. Findings suggest that hydrogen peroxide-inducible clone-5 (Hic-5) is involved in changes in the mesangial cells (MCs) phenotype to produce abnormal extracellular matrix remodeling in glomerulonephritis (GN). PMID: 22286178
19. these results provide the first evidence for a physical and mutual functional interaction between Hic-5 and the BMP signaling pathway. PMID: 21996749
20. Transforming growth factor-beta1-induced transcript 1 protein, a novel marker for smooth muscle contractile phenotype, is regulated by serum response factor/myocardin protein. PMID: 21984848
21. Hic-5 is essential for adhesion formation in 3D extracellular matrices. PMID: 21148292
22. Hic-5/ARA55 expression in response to castration-enabled epithelial regression through the repression of c-myc gene at the chromatin level. PMID: 20818421
23. Hic-5/ARA55 has roles in keloids through Smad pathway and profibrotic transcription PMID: 20395114
24. Hydrogen peroxide-inducible clone 5 is expressed predominantly in pyramidal neurons of human hippocampus. PMID: 20448481
25. coregulator of androgen receptor coativation, suppresssed by Pyk2 PMID: 11856738
26. that hic-5 plays a role in the initial stage of myogenic differentiation. PMID: 11937715
27. Results suggest that paxillin and Hic-5 associate with GIT1 with different binding modes. PMID: 12153727
28. a key element in the transduction of signals from the cell surface to the nucleus under oxidative stress-review PMID: 12400158
29. results suggest that Hic-5 participates in the transcriptional regulation of c-fos as a scaffold in transcriptional complexes. PMID: 12445807
30. Results show that Hic-5 accumulates in the nucleus in response to oxidants such as hydrogen peroxide PMID: 12631731
31. Higher ARA55 expression may result in unfavorable recurrence-free survival and overall survival in hormone-refractory prostate cancer PMID: 12858356
32. the C terminus of ARA55 is critical for suppression of Smad3 activity PMID: 15561701
33. Hic-5/ARA55 is required for optimal GR-mediated gene expression possibly by providing a scaffold that organizes or stabilizes coactivator complexes at some hormone-responsive promoters. PMID: 16141357
34. human ERK8 has a role as a negative regulator of human GRalpha, acting through Hic-5 PMID: 16624805
35. Small interfering RNA ablation experiments established endogenous Hic-5/ARA55 as a coactivator for both viral and endogenous cellular AR-regulated genes. PMID: 16849583
36. Review highlights the role that Hic-5 may play in regulating androgen-induced growth factor signaling and/or cytokine expression in the prostate. PMID: 17166536
37. Hic-5/ARA55 is a molecular regulator for androgen sensitivity in human hair follicles. PMID: 17508020
38. The increased expression of ARA55 is a feature of nonobstructive azoospermia. PMID: 17919607
39. Silencing Hic-5 in hypertrophic scar fibroblasts reduces TGF-beta1 production, decreases generation of supermature focal adhesions, reduces expression of smooth-muscle cell alpha-actin and decreases collagen contraction and extracellular matrix synthesis. PMID: 18401422
40. The level of Smad7 is modulated by its physical interaction with Hic-5 and targeted to a degradation pathway not likely to be proteasomal PMID: 18762808
41. The data suggest that the proposed progesterone resistance in endometrium from women with endometriosis derives, in part, from impaired expression of the PR coactivator, Hic-5, in endometrial tissue and cultured endometrial stromal fibroblasts. PMID: 19389829

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HGNC: 11767

OMIM: 602353

KEGG: hsa:7041

STRING: 9606.ENSP00000378332

UniGene: Hs.513530