Recombinant Human Transient receptor potential cation channel subfamily M member 3 (TRPM3), partial

1. this study shows that differential expression of TRPM3 and Ca2+ flux between NK cell subtypes may provide evidence for their role in the pathomechanism involving NK cell cytotoxicity activity in chronic fatigue syndrome/myalgic encephalomyelitis PMID: 27727448
2. rs10780946 TRPM3 polymorphism is associated with asthma-exacerbated respiratory disease susceptibility. PMID: 26891941
3. Phosphoinositols regulate TRPM3. PMID: 26517445
4. Activation of TRPM3 channels increases the transcriptional activation potential of c-Fos in HEK293 cells. PMID: 26493679
5. This is the first study to examine the involvement of TRPM channel gene variations on the risk of SSc incidence. Our results suggest roles of TRPM3 and TRPM5 gene variants in the susceptibility to or clinical expression of Systemic sclerosis PMID: 26546534
6. The TRPM3 activity is rapidly and reversibly inhibited by activation of phosphatases. PMID: 26123194
7. TRPM3 is a phosphoinositide-dependent ion channel. PMID: 26123195
8. Missense mutation in the cation channel, TRPM3, underlies inherited cataract and glaucoma. PMID: 25090642
9. TRPM3 channel activation changes the gene expression pattern of the cells by activating transcription of c-Jun-, ATF2-, and TCF-controlled genes. PMID: 25576487
10. The von Hippel-Lindau tumor suppressor (VHL) represses TRPM3 directly through miR-204 and indirectly through another miR-204 target, Caveolin 1. PMID: 25517751
11. Pregnenolone sulfate is a powerful activator of TRPM3-mediated gene transcription, while transcription is completely inhibited by mefenamic acid in cells expressing activated TRPM3 channels. PMID: 24895737
12. Data using recombinant proteins expressed in vascular endothelial cells suggest that SigmaR1 (sigma 1-type opioid receptor) is not involved in regulation of calcium signaling via TRPC5/TRPM3 (transient receptor potential cation channels C5/M3). PMID: 23121507
13. TRPM3-ICF deletion mutation variants are regulatory channel subunits fine-tuning TRPM3 channel activity. PMID: 22961981
14. Progesterone (0.01-10muM) suppressed TRPM3 activity evoked by pregnenolone sulphate. PMID: 22000496
15. Calmodulin and S100A1 protein interact with N terminus of TRPM3 channel. PMID: 22451665
16. The inhibition of TRPM1 by zinc ions is primarily due to a short stretch of seven amino acids present only in the pore region of TRPM1 but not of TRPM3. PMID: 21278253
17. Our data establish that TRPM3 channels constitute a regulated entry pathway for zinc ions in pancreatic beta-cells PMID: 20401728
18. data suggest functional relevance of TRPM3 in contractile and proliferating phenotypes of vascular smooth muscle cells PMID: 20360246
19. The hTRPM3 gene is comprised of 24 exons and maps to chromosome 9q-21.12 and is composed of 1555 amino acids with the characteristic six-transmembrane domain of TRPs and is expressed in kidney and, at lesser levels, in brain, testis, and spinal cord PMID: 12672827
20. TRPM3 is the first ion channel activated by sphingolipids. PMID: 15550678
21. the divalent cation selectivity of TRPM3 channels is regulated by altenrative splicing PMID: 15824111
22. we give an overview of the identified TRPM3 variants and compare their functional properties--{REVIEW} PMID: 17217062
23. TRPM3 did not reveal a otosclerosis-causing mutation PMID: 18224337

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HGNC: 17992

OMIM: 608961

KEGG: hsa:80036

STRING: 9606.ENSP00000366314

UniGene: Hs.47288