Recombinant Human Tribbles homolog 2 (TRIB2)

1. Data indicate a regulatory mechanism underlying drug resistance and suggest that tribbles homologue 2 (TRIB2) functions as a regulatory component of the PI3K network, activating AKT in cancer cells. PMID: 28276427
2. Due to the downregulation of MDR1 and MRP1, the intracellular accumulation of ADM was increased in the transfected cells compared with that in the parental K562/ADM cells..Our research revealed that protein expression of the ERK signaling pathway was inhibited by downregulating TRIB2, indicating that the ERK pathway was involved in cell drug resistance and proliferation. PMID: 29436678
3. Trib2 is important for maintaining self-renewal in ES cells and for pluripotency induction during the reprogramming process. PMID: 29170476
4. O-GlcNAcylation of TRIB2 might be critical for diabetes-associated liver cancer. PMID: 27515988
5. Tumors from resistant patients expressed the lowest levels of TRIB2. Downregulation of TRIB2 contributes to platin-resistance. PMID: 28670762
6. our data show that excess p30 cooperated with TRIB2 only in the presence of p42 to accelerate acute myeloid leukaemia (AML), and the direct interaction and degradation of C/EBPa p42 is required for TRIB2-mediated AML. PMID: 26996668
7. miR-206 and miR-140, as tumor suppressors, induced lung adenocarcinoma cell death and inhibited cell proliferation by modifying oncogenic TRIB2 promoter activity through p-Smad3. PMID: 28005074
8. Studied effect of TRIB2 SNP on the expression of genes involved in adaptive thermogenesis using messenger RNAs prepared from adipose tissues of Japanese adults. Of the five thermogenic genes, DIO2, CIDEA, PPARGC1A, and PRDM16 showed significantly higher transcript levels in SAT of individuals with the AA genotype relative to those with the AT + TT genotype. PMID: 28212671
9. Data show that TRIB2-mediated degradation of CDC25C is associated with lysine-48-linked CDC25C polyubiquitination driven by the TRIB2 kinase-like domain. PMID: 27563873
10. High TRIB2 reinforces the oncogenic transcriptional program controlled by the TAL1 complex in T-cell acute lymphoblastic leukemia. PMID: 26202930
11. Studies suggest that tribbles homolog 2 (Drosophila) protein (TRIB2) as a meaningful biomarker to both diagnose and stage melanoma. PMID: 26517928
12. Studies indicate that the molecular interactions that take place between tribbles homolog 2 (Drosophila) protein (TRIB2) and factors involved in the ubiquitin proteasome system (UPS) are varied and have differential downstream effects. PMID: 26517929
13. The results suggest that TRIB2 is a meaningful biomarker reflecting diagnosis and progression of melanoma, as well as predicting clinical response to chemotherapy. PMID: 25586991
14. Data suggest that TRB2 exhibits metal-independent autophosphorylation activity, low affinity ATP binding/hydrolysis, and a conserved catalytic lysine residue in the active site (rather than the asparagine in many metal-dependent kinases). PMID: 25583260
15. TRIB2 negatively regulates Wnt activity through a reduction in protein stability of TCF4 and beta-Catenin PMID: 25311538
16. we identify the contribution of dysregulated C/EBPalpha and E2F1 to elevated Trib2 expression and leukemic cell survival PMID: 24516045
17. this study reveals that the stability and ubiquitination of TRIB2 can be also controlled by Ubiquitin E3 ligase SCFb-TRCP. PMID: 24211582
18. impaired phosphorylation and ubiquitination by p70S6K and Smurf1 increase the protein stability of TRIB2 in liver cancer PMID: 24089522
19. through regulating the expression of TRIB2 and its downstream factors, let-7c can effectively inhibit A549 cell proliferation in vitro and in vivo PMID: 23850892
20. results illustrate that miR-511 and miR-1297 act as tumor suppressor genes, which could suppress A549 cell proliferation in vitro and in vivo by suppressing TRIB2 and further increasing C/EBPalpha expression PMID: 23071539
21. Positive natural selection of TRIB2, a novel gene that influences visceral fat accumulation, in East Asia. PMID: 23108367
22. Our findings here support the ability of high TRIB2 expression to reveal a T cell profile in both T cell acute lymphoblastic leukaemias and acute myeloid leukaemias. PMID: 22775572
23. We have identified a SNP near the TRIB2 locus that is associated with pericardial fat but not with body mass index or visceral abdominal fat. PMID: 22589742
24. Low Trib2 is associated with inflammatory bowel disease. PMID: 22271508
25. TRIB2 as a potential driver of lung tumorigenesis through a mechanism that involves downregulation of C/EBPalpha PMID: 21399661
26. our data demonstrate that Trib2 can bind both COP1 and C/EBP-alpha, leading to degradation of C/EBP-alpha. PMID: 20805362
27. Downregulation potentiates IL-8 production by human monocytes via enhanced activation of the ERKs and JNK/MAPK pathways PMID: 18952906
28. Trb-2 expression was reduced in acute myeloid leukaemia compared to healthy controls PMID: 20005259
29. studies have found increased autoantibodies against Tribbles homolog 2 in narcolepsy PMID: 20614846
30. A study reported an increased prevalence of autoantibodies against Tribbles homolog 2 (TRIB2) in patients with narcolepsy PMID: 20614847
31. Overexpression of TRIB2 is associated with malignant melanoma. PMID: 20208562
32. Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients. PMID: 20160349
33. Anti-TRB2 antibody activities were detected in several autoimmune uveitis patients but not in control subjects, suggesting that TRB2 is a uveitis-associated candidate autoantigen. PMID: 15950723
34. TRB2-Mcl-1 axis plays an important role in survival factor withdrawal-induced apoptosis of TF-1 erythroleukemia cells. PMID: 17545167

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HGNC: 30809

OMIM: 609462

KEGG: hsa:28951

STRING: 9606.ENSP00000155926

UniGene: Hs.467751