Recombinant Mouse Carbohydrate-responsive element-binding protein (Mlxipl), partial

1. ChREBP and SHP control the regulation of hepatic microsomal triglyceride transfer protein expression and VLDL Secretion. Adenoviral Overexpression of ChREBP and SHP Respectively Increased and Decreased Mttp Expression. PMID: 29518948
2. Data, including data from studies in knockout mice, suggest that ChREBP is involved in coordinate regulation of sucrose and fructose absorption/metabolism by modulating gene expression in intestinal mucosa and liver. PMID: 29534502
3. Authors have identified a previously unappreciated negative feedback loop by which glucose-induced ChREBP-beta downregulates ChREBP-alpha-signaling providing new insight into the physiological role of islet ChREBP-beta and into the regulation of glucose-induced gene expression. PMID: 27900263
4. loss of adipose-ChREBP is sufficient to cause insulin resistance potentially by regulating AT glucose transport. PMID: 29069585
5. Glucose-challenged Chrebp-/- mice exhibit a marked reduction in FGF21 production. PMID: 29020627
6. Study identify O-GlcNAcylation on Ser514 in the C-terminus of ChREBP and validate two important sites, Thr517 and Ser839 for O-GlcNAcylation and their function. Ser514 phosphorylation enhances ChREBP O-GlcNAcylation, maintaining the transcriptional activity of ChREBP; Ser839 O-GlcNAcylation is essential for its heterodimerization, DNA-binding activity, and nuclear export. PMID: 28450420
7. findings suggest that a previously unknown link exists between ChREBP and the regulation of cholesterol synthesis that affects liver injury. PMID: 28628039
8. findings also identified a role for ChREBP in regulating SREBP2-dependent cholesterol metabolism. PMID: 28628040
9. these findings support a carbohydrate-mediated, ChREBP-driven mechanism that contributes to hepatic insulin resistance. PMID: 27669460
10. a high complex carbohydrate diet selectively increases hepatic ChREBPbeta expression, which associates with hepatic steatosis but not insulin resistance. In contrast, a high fat diet reduces adipose ChREBP, which associates with inflammation and insulin resistance. PMID: 27992582
11. The results revealed the novel mechanism by which HNF-4alpha promoted ChREBP transcription in response to glucose, and also demonstrated that ChREBP-alpha and HNF-4alpha synergistically increased ChREBP-beta transcription. PMID: 27029511
12. Adipose tissue mTORC2 regulates via Rictor ChREBP-driven de novo lipogenesis and hepatic glucose metabolism. PMID: 27098609
13. Diet-induced obesity increases basal expression of ChREBPbeta, which may increase the risk of developing hepatic steatosis, and fructose-induced activation is independent of gluconeogenesis. PMID: 26526060
14. Targeted deletion of ChREBP in bone marrow cells resulted in accelerated atherosclerosis progression in Ldlr-/- mice with increased monocytosis, lesional macrophage accumulation, and plaque necrosis. PMID: 26411684
15. Evaluation of the conservation of ChREBP and MondoA sequences demonstrate that MondoA is better conserved and potentially mediates more ancient function in glucose metabolism. PMID: 26910886
16. Data show that the weight gain was blunted in male, but not female, fatty acid binding protein 4-Cre-driven promoter (FaChOX) mice when placed on either a normal chow diet or an obesogenic Western diet. PMID: 26248218
17. Data show that carbohydrate-response element-binding protein (ChREBP) activation induces peroxisome proliferator-activated receptor (PPARgamma) activity and ChREBP inhibition impairs differentiation. PMID: 26181104
18. Data suggest expression of ChREBPbeta isoform is up-regulated in pancreatic beta-cells in response to elevated glucose (i.e., hyperglycemic conditions); RNA interference of ChREBPbeta prevents beta-cell proliferation in response to hyperglycemia. PMID: 26384380
19. hyperinsulinemia may cause glycolipid metabolic disorders by up-regulating the expression of ChREBP PMID: 25212036
20. The effects of ethanol on AMPK and PP2A may result in activation of ChREBP, providing another potential mechanism for ethanol-induced hepatic steatosis. PMID: 23266705
21. Depletion of ChREBP decreased glucose-stimulated proliferation in beta-cells isolated from ChREBP(-/-) mice, in INS-1-derived 832/13 cells, and in primary rat and human beta-cells PMID: 22586588
22. Data indicate that ChREBP is a key transcription factor that mediates many of the hyperglycaemia-induced activations in a gene expression programme that underlies beta cell glucotoxicity at the molecular, cellular and whole animal levels. PMID: 22382520
23. ChREBP overexpression induced expression of stearoyl-CoA desaturase 1 (Scd1), the enzyme responsible for the conversion of saturated fatty acids (SFAs) into MUFAs PMID: 22546860
24. adipose ChREBP is a major determinant of adipose tissue fatty acid synthesis and systemic insulin sensitivity PMID: 22466288
25. an important mechanism by which importin-alpha and 14-3-3 control movement of ChREBP in and out of the nucleus in response to changes in glucose levels in liver PMID: 21665952
26. ChREBP was unexpectedly required during fasting for maximal Rgs16 transcription in liver and in cultured primary hepatocytes during gluconeogenesis. PMID: 21357625
27. Results reveal that O-GlcNAcylation represents an important novel regulation of ChREBP activity in the liver under both physiological and pathophysiological conditions. PMID: 21471514
28. ChREBP is a critical and direct mediator of glucose repression of PPARalpha gene expression in pancreatic beta-cells PMID: 21282101
29. Carbohydrate response element-binding protein (ChREBP), a glucose-dependent transcription factor downstream of Protein phosphatase 2A, partially mediated the effects of glucose on metabolic markers. PMID: 21215280
30. The db/db mouse exhibits significantly higher liver ChREBP activity, which may be associated with the development of hepatic steatosis frequently occurring in type 2 diabetes. PMID: 19727214
31. Data showed that the steatosis is accompanied by altered expression of a number of genes, including increased expression of ChREBP, which acts as one of the central determinants of lipid synthesis in the liver. PMID: 21103071
32. low SIK2 activity was associated with increased p300 HAT activity, ChREBP hyperacetylation, and hepatic steatosis PMID: 21084751
33. ChREBP is an attractive target to alleviate derangements in lipid metabolism observed in patients with glycogen storage disease. PMID: 20854262
34. ChREBP inactivation in clonal pancreatic MIN6 beta-cells results in an increase in Pdx-1 expression at low glucose and to a small, but significant, increase in Ins2, GcK and MafA gene expression at high glucose concentrations. PMID: 20934404
35. Data demonstrate that expression of carbohydrate response element-binding protein (ChREBP or Mlxipl), an important transcriptional regulator of carbohydrate metabolism, is significantly affected in compound Foxa1/a2 mutant beta-cells. PMID: 20534694
36. These multiple lines of evidence support the conclusion that G-6-P mediates the activation of ChREBP. PMID: 20382127
37. ChREBP acts as a novel repressor of the ARNT/HIF-1beta gene and thus may contribute to beta-cell dysfunction induced by glucotoxicity. PMID: 19833882
38. ChREBP is important modulator of adipocytes and its expression in adipose tissue is subject to combined regulation by glucose and insulin. Induction of ChREBP may serve as novel pharmacological pathway for troglitazone-mediated hypoglycemic effects. PMID: 15100094
39. is required both for basal and carbohydrate-induced expression of several liver enzymes essential for coordinated control of glucose metabolism, fatty acid, and the synthesis of fatty acids and triglycerides in vivo PMID: 15118080
40. role of ChREBP in the glucose regulation of two key liver lipogenic enzymes, acetyl-CoA carboxylase and fatty acid synthase PMID: 15496471
41. The results of this study suggest that inactivation of ChREBP expression not only reduces fat synthesis and obesity in ob/ob mice but also results in improved glucose tolerance and appetite control. PMID: 16705063
42. results demonstrate that carbohydrate responsive element-binding protein (ChREBP) is central for the regulation of lipogenesis in vivo and plays a determinant role in the development of the hepatic steatosis and of insulin resistance in ob/ob mice PMID: 16873678
43. ChREBP is a critical regulator of lipogenic genes in the beta cell and may play a role in the development of glucolipotoxicity and beta cell failure through alteration of gene expression in type 2 diabetes PMID: 16891625
44. The shift from fat utilization to pyruvate and lactate utilization resulted in a decrease in the energy of ATP hydrolysis and a hypo-energetic state in the livers of ChREBP(-/-) mice. PMID: 18042547
45. ChREBP can regulate metabolic gene expression to convert excess carbohydrate into triglyceride rather than glycogen.[review] PMID: 18490833
46. Phosphorylation of ChREBP was essential for its interaction with CRM1 for export to the cytosol, whereas nuclear import of ChREBP requires dephosphorylated ChREBP to interact with importin alpha. PMID: 18606808
47. The transcription factor ChRepsilonBP is a major mediator of glucose action on lipogenic genes & a key determinant of lipid synthesis in vitro. In mice, it plays a central role in hepatic steatosis & insulin resistance physiopathology. Review. PMID: 18950580
48. study demonstrated that thyroid hormone up-regulated ChREBP mRNA and protein expression in liver PMID: 19324998

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KEGG: mmu:58805

STRING: 10090.ENSMUSP00000005507

UniGene: Mm.34213