Recombinant Mouse Caspase-2 (Casp2)

1. A novel function for caspase-2 in myocyte differentiation and myogenesis. PMID: 28765049
2. Casp2(-/-) mice, which are more susceptible to genomic instability, are limited in their ability to respond to DNA damage and thus carry more damaged cells resulting in accelerated tumourigenesis. PMID: 27518436
3. BECN1/Beclin 1 binding to viral phosphoprotein (P) induced an incomplete autophagy via activating the pathways CASP2-AMPK-AKT-MTOR and CASP2-AMPK-MAPK by decreasing CASP2. PMID: 28129024
4. We further generated Casp2(C320S) mutant mice to demonstrate that caspase-2 catalytic activity is essential for its function in limiting aneuploidy. Our results provide direct evidence that the apoptotic activity of caspase-2 is necessary for deleting cells with mitotic aberrations to limit aneuploidy PMID: 27991927
5. These results provide the first evidence of caspase-2 in regulating haematopoietic stem cell and progenitor differentiation, as well as aneuploidy, in vivo. PMID: 27906175
6. Study describes a novel pathological process in which caspase-2 cleavage of tau at Asp314 impairs cognitive and synaptic function in animal and cellular models of tauopathies by promoting the missorting of tau to dendritic spines. PMID: 27723722
7. Caspase-2 deficiency protected mice from diet-induced obesity, metabolic syndrome and nonalcoholic fatty liver disease. PMID: 26890135
8. The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd PMID: 25857265
9. Data show that indoles can effectively suppress acute hepatic inflammation caused by staphylococcal enterotoxin B (SEB) maybe mediated by decreased expression of miR-31 and caspase-2-dependent apoptosis in T cells. PMID: 25706292
10. Data indicate that the nucleotide-binding domain and leucine-rich repeat containing (NLRP3)-caspase-2 axis drives general endoplasmic reticulum (ER) stress-induced inflammasome activation. PMID: 26341399
11. these studies elucidate a Caspase-2-p53 signaling network that impacts lung tumorigenesis and chemotherapy response in vivo. PMID: 25301067
12. data strongly suggest that caspase-2 deficiency leads to increased cellular stress largely because these mice fail to respond to oxidative stress by upregulating their antioxidant defense mechanism PMID: 25531319
13. These results demonstrate an important role for caspase-2 in regulating proteome and metabolome remodelling during ageing. PMID: 25611376
14. Caspase-2 is not a suppressor in MYCN-induced neuroblastoma and suggest a tissue and context-specific role for caspase-2 in tumorigenesis. PMID: 25144718
15. our data point to a critical and novel role for caspase-2 in maintaining bone homeostasis by modulating ROS levels and osteoclast apoptosis during conditions of enhanced oxidative stress that occur during aging PMID: 24691516
16. Report the novel finding that CASP2 is an endogenous repressor of autophagy. Knockout or knockdown of CASP2 resulted in upregulation of autophagy in a variety of cell types and tissues. PMID: 24879153
17. Caspase-2 activation is one of the few early molecular events identified in Parkinson disease models. PMID: 25645943
18. The involvement of caspase 2 and iNOS-mediated apoptotic signaling in nicotine plus high fat diet-induced hepatocellular apoptosis, is reported. PMID: 24830635
19. Axin expression may facilitate AKI-induced caspase-2 activation followed by activation of PARP and initiation of the necrotic cell death pathway. PMID: 24287941
20. Data strongly argue against a critical role for caspase-2 in ER-stress-induced apoptosis. PMID: 24292555
21. caspase-2 is a tumor suppressor in epithelial cancers such as breast cancer, and may be an important genetic marker for aggressive disease and poor prognosis. PMID: 23645210
22. Loss of caspase-2 accelerates age-dependent alterations in mitochondrial production of reactive oxygen species. PMID: 23504374
23. caspase-2 is required for the cognitive decline seen in human amyloid precursor protein transgenic mice. PMID: 23748737
24. The findings suggest that loss of caspase-2 serves as a key function in maintaining genomic integrity, during cell proliferation and following DNA damage. PMID: 22498700
25. Brucella abortus strains RB51 and S2308-induced BMDC cell death was regulated by caspase-2 PMID: 22927979
26. Caspase-2 showed tumor suppressive capacity in response to aberrant c-Myc expression, which did not rely on PIDD, the BH3-only protein Bid or the death receptor ligand Trail. PMID: 22595758
27. IRE1alpha regulates translation of a proapoptotic protein, Caspase-2, through terminating microRNA biogenesis, and noncoding RNAs are part of the ER stress response PMID: 23042294
28. caspase-2 gene deficiency combined with hypothermia provided enhanced neuroprotection as compared with hypothermia alone PMID: 22322383
29. Activation of neuronal Casp2 and induction of this activity depends on expression of receptor-interacting protein RAIDD, but is independent of p53-inducible protein with a death domain (PIDD) expression. PMID: 22515271
30. Casp2-deficient mice subjected to hypoxia-ischemia at postnatal day 9 present significantly lower cerebral infarction, reduced white matter injury, and reduced Casp3 activation in the thalamus and hippocampus. PMID: 21674587
31. ras-induced down-regulation of caspase-2 represents a novel mechanism by which oncogenic Ras protects malignant intestinal epithelial cells from anoikis PMID: 21903589
32. caspase-2 deficiency may play a role in promoting marrow adiposity under stress or disease conditions PMID: 21538476
33. a novel function of caspase-2 in mitochondrial oxidative stress-induced apoptosis in neurons cultured from young adult mice. PMID: 21216964
34. caspase 2, an initiator caspase, localizes to the centrosomes in mitotic primary mouse embryonic fibroblasts, irrespective of DNA mismatch repair status and ultraviolet radiation B treatment. PMID: 20022306
35. mechanism for caspase-2 nuclear import PMID: 12477715
36. Caspases other than caspases 2 and 9 can promote cytochrome c release and initiate Bcl-2-regulated apoptosis. PMID: 15210727
37. caspase-2 and caspase-8 activation have roles in the mitochondrial apoptotic pathway induced by ceramide or etoposide PMID: 15262979
38. demonstrate the inducible assembly of a novel protein complex consisting of caspase-2, TRAF2, and RIP1 that activates NF-kappaB and p38 MAPK PMID: 15590671
39. These results suggest that caspase-2 activation mediated by p53 is an important pathway involved in the mitochondrial release of apoptosis-inducing factor in response to cisplatin injury. PMID: 15983031
40. Caspase-2 contributes to P53-induced protein with a death domain-mediated cell death, but that it is not the sole effector of this pathway. PMID: 16183742
41. caspase-2 is an early checkpoint for apoptosis initiation in primary neurons subjected to serum deprivation. PMID: 16215683
42. This approach unambiguously identifies the apical caspase activated in response to apoptotic stimuli, and establishes caspase-2 as a proximal mediator of heat shock-induced apoptosis. PMID: 16362053
43. caspase 2 plays an important role upstream of the mitochondria in germ cell apoptosis during the first phase of spermatogenesis PMID: 16481596
44. caspase-2 deficiency affects aging in the mice PMID: 17188333
45. These results indicate a role for GSK-3beta in ceramide-induced apoptosis, in which GSK-3beta acts downstream of PP2A and the PI 3-kinase-Akt pathway, and upstream of caspase-2 and caspase-8. PMID: 17666435
46. our data indicate that caspase 2 and JNK-mediated intrinsic pathway signaling is one of the mechanisms involved in age-related increase in muscle cell apoptosis. PMID: 18461459
47. results revealed the presence of caspase-2(L), caspase-9, and caspase-3 in their zymogen and cleaved forms in the oocyte before meiosis resumption PMID: 19035350
48. loss of caspase-2 results in an increased ability of cells to acquire a transformed phenotype and become malignant, indicating that caspase-2 is a tumor suppressor protein. PMID: 19279217
49. Results suggest that at least one alternative PIDDosome-independent mechanism of caspase-2 activation exists in mammals in response to DNA damage. PMID: 19364921
50. Caspase-2 phosphorylated at S135 binds 14-3-3zeta, thus preventing C2 dephosphorylation. PMID: 19531356

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KEGG: mmu:12366

STRING: 10090.ENSMUSP00000031895

UniGene: Mm.3921