Recombinant Mouse Cholesterol side-chain cleavage enzyme, mitochondrial (Cyp11a1)

1. melatonin not only elevated progesterone (P) secretion, but also upregulated expressions of StAR and Cyp11a1 and also had an increased Ihh expression in endometrium. PMID: 28749439
2. reduction in expression mirrored reduction in adrenal corticosterone output PMID: 29046340
3. The results demonstrated that ZnT7 gene silencing downregulated the expression of StAR, P450scc and 3beta-HSD as well as progesterone concentrations in the human chorionic gonadotrophin-stimulated Leydig tumor cells. PMID: 27121848
4. 1,25D3 modulates CD8+ T cell phenotype via recruitment of the VDR transcription factor to the promoter region of Cyp11a1 leading to prevention of lung allergic responses. PMID: 26750596
5. Data from Cyp11a1 transgenic mice suggest that overexpression of Cyp11a1 results in reduced pregnancy rate, impaired implantation/placentation, decreased litter size, and stillbirth; overexpression of Cyp11a1 disrupts development of corpus luteum. PMID: 23966322
6. Cyp11a1 plays an important role in the development of peanut allergy, regulating peanut-induced allergic responses through effects on steroidogenesis, an essential pathway in T(H)2 differentiation. PMID: 23870673
7. Cyp11a1 controls the phenotypic conversion of CD8(+) T cells from IFN-gamma to IL-13 production, linking steroidogenesis in CD8(+) T cells, a nonclassical steroidogenic tissue, to a proallergic differentiation pathway PMID: 23630275
8. Sodium fluoride inhibited expression of StAR and P450scc in mouse Leydig tumor cells, which inhibited progesterone secretion. PMID: 22443068
9. LH/hCG tightly regulates MKP-2 expression, which modulates the induction of CYP11A1 by 8Br-cAMP. PMID: 23471219
10. Cyp11a1 null embryos had adrenal medulla with abnormal mitochondria. Cells did not synthesized no epinephrine. Decreased diencephalon Hsd11b1, increased Crh, and increased pituitary Pomc expression, thus higher plasma ACTH PMID: 22962254
11. Data suggest that the 5' flanking region of CYP11A gene contains sequences between 2.5 and 5 kb that are necessary for expression of mouse CYP11A in Leydig cells but not in adrenal cells. [REVIEW] PMID: 22217834
12. Daxx, a HIPK kinase substrate in the apoptosis pathway, was phosphorylated by HIPK3 at Ser-669 in response to cAMP stimulation. PMID: 22199361
13. Prenatal exposure to ethanol increased expressions of StAR and P450scc in maternal adrenal and decreased them in fetal adrenal. PMID: 20627497
14. Pubertal Cd exposure markedly reduced mRNA and protein levels of testicular StAR, P450scc, P450(17alpha) and 17beta-HSD in mice. PMID: 19897027
15. Transcription of cholesterol side-chain cleavage cytochrome P450 in the placenta: activating protein-2 assumes the role of steroidogenic factor-1 by binding to an overlapping promoter element. PMID: 12145340
16. Cyp11a1 null mice display a lack of steroid production, abnormal gene expression, and aberrant reproductive organ development resemble various steroid deficiency syndromes. PMID: 12145347
17. Male CYP11A1 null mice are feminized and their adrenals and genitalia accumulate excessive amounts of lipid PMID: 12530664
18. Proximal SF-1 binding site plays important role in regulating tissue-specific expression of Cyp11a1 and stress response. PMID: 15666831
19. This study sought to elucidate overlooked modes of regulation of P450scc transcription in the rodent placenta and ovary. PMID: 17213386
20. SF-1 and AP-1 cooperate to activate CYP11A1 transcription in vitro and in vivo. PMID: 17218410
21. Data show that HDAC inhibitors suppressed the expression of steroidogenic gene CYP11A1 and decreased steroid secretion by increasing the ubiquitination and degradation of SF-1, a factor important for the transcription of all steroidogenic genes. PMID: 17709382
22. Data show that the mutation of the SF-1 response element of Cyp11a1 results in reduced stress response due to decreased adrenal CYP11A1 expression and insufficient stress-induced glucocorticoids secretion. PMID: 18174359
23. Heterologous expression in yeast of mCYP11A1 fusions with different topogenic signals of yeast mitochondrial proteins was used to gain insight in the mechanism of its topogenesis in mitochondria. PMID: 18621100
24. Lycopene protects against PCB-induced changes in Leydig cellular StAR protein, cytochrome P450 scc expression and activity of 3beta-HSD. PMID: 19071209

Show More

Hide All

KEGG: mmu:13070

STRING: 10090.ENSMUSP00000034874

UniGene: Mm.302865