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Recombinant Mouse Delta-like protein 3 (Dll3), partial

Code CSB-YP006948MO1
MSDS
MSDS Datasheet
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Source Yeast
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Code CSB-EP006948MO1
MSDS
MSDS Datasheet
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Source E.coli
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Code CSB-EP006948MO1-B
MSDS
MSDS Datasheet
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP006948MO1
MSDS
MSDS Datasheet
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Source Baculovirus
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Code CSB-MP006948MO1
MSDS
MSDS Datasheet
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Dll3
Uniprot No.
O88516
Alternative Names
Dll3; Delta-like protein 3; Drosophila Delta homolog 3; Delta3; M-Delta-3
Species
Mus musculus (Mouse)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Protein FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Customer Reviews and Q&A

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■ Q&A
Q:

Regarding your protein CSB-EP006948MO1, could you please advise whether the proteins expressed by this and the 3 other hosts are secreted proteins, in inclusion bodies, or other?

A:
Regarding your question, as we haven't expressed these proteins before, we are not sure if they will form inclusion bodies during the expression,however, even if they form inclusion bodies, we will conduct inclusion body renaturation to ensure that all of the proteins provided are soluble form.
Q:

I am most concerned about the high-cysteine content of this protein, because I need the disulfide bonds to be properly formed. I would like to know if any of the eukaryotic versions of this protein are “secreted” – could you please advise on this?

A:
Thanks for your inquiry. Your concern is reasonable. This protein is easy to form inclusion bodies. In this case, we recommend you to choose Yeast expressed protein or Mammalian cell expressed protein. What we provide is the secreted protein.

Target Background

Function
Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.
Gene References into Functions
  1. Structural deformities of the vertebral column and adjacent ribs in the pudgy mouse are caused by mutations in Dll3. Review. PMID: 27655002
  2. Dll3 overexpression promoted PI3K/Akt signaling through inhibiting Notch signaling in lung cancer. PMID: 28007595
  3. O-fucosylation of DLL3 is required for its function during somitogenesis. PMID: 25856312
  4. Intriguing changes are observed in the cranio-caudal borders of multifidus muscle in mutant Dll3 and Lfng models of idiopathic scoliosis. PMID: 22095884
  5. Dll3 has a unique function during T-cell development that is distinct from the role played by the other DSL ligands of Notch. PMID: 21151194
  6. Dll3 targets Notch1 for lysosomal degradation preventing Notch1 from undergoing post-translational processing. PMID: 21147753
  7. Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm. PMID: 11923214
  8. DLL3 knockout mice have segmentation and neural defects PMID: 12141422
  9. spondylocostal dysostosis (SCD) is caused by mutation in Delta-like 3 (DLL3), Mesoderm posterior 2 (MESP2), and Lunatic fringe (LFNG); three genes that are components of the Notch signaling pathway. PMID: 17600782
  10. study reports that another Notch ligand, Dll3, is expressed in developing hair cells, in a pattern that overlaps that of Dll1 and Jag2; Dll3 may play a role in lateral inhibition similar to that of Dll1 and Jag2 PMID: 17823936
  11. study shows that genetic interactions between Notch1 and Dll3 result in vertebral segmental defects similar to those seen in congenital scoliosis; craniofacial anomalies not previously observed in Dll3 homozygous animals were identified PMID: 17849441
  12. Dll3 are expressed in the developing mouse eye and in retinal progenitor cell. PMID: 19191219
  13. a complex interplay of E-box binding proteins spatially and temporally regulate Dll3 levels during neural tube development. PMID: 19389376
  14. Data show that the ubiquitin ligase Huwe1 operates upstream of the N-Myc-DLL3-Notch pathway to control neural stem cell activity and promote neurogenesis. PMID: 19686682

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Involvement in disease
A truncating mutation in Dll3 is the cause of the pudgy (pu) phenotype. Pudgy mice exhibit patterning defects at the earliest stages of somitogenesis. Adult pudgy mice present severe vertebral and rib deformities.
Subcellular Location
Membrane; Single-pass type I membrane protein.
Tissue Specificity
Predominantly expressed in the neuroectoderm and paraxial mesoderm during embryogenesis.
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Related pathways
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