Recombinant Mouse Delta-like protein 3(Dll3)

Code CSB-CF006948MO
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. O88516
Storage Buffer Tris-based buffer,50% glycerol
Species Mus musculus (Mouse)
Sequence HSFGPGPGLGTPRSPCNARGPCRLFFRVCLKPGVSQEATESLCALGAALSTSVPVYTEHPGESAAALPLPDGLVRVPFRDAWPGTFSLVIETWREQLGEHAGGPAWNLLARVVGRRRLAAGGPWARDVQRTGTWELHFSYRARCEPPAVGAACARLCRSRSAPSRCGPGLRPCTPFPDECEAPSVCRPGCSPEHGYCEEPDECRCLEGWTGPLCTVPVSTSSCLNSRVPGPASTGCLLPGPGPCDGNPCANGGSCSETSGSFECACPRGFYGLRCEVSGVTCADGPCFNGGLCVGGEDPDSAYVCHCPPGFQGSNCEKRVDRCSLQPCQNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGSRRCSCALGFGGRDCRERADPCASRPCAHGGRCYAHFSGLVCACAPGYMGVRCEFAVRPDGADAVPAAPRGLRQADPQRFLLPPALGLLVAAGLAGAALLVIHVRRRGPGQDTGTRLLSGTREPSVHTLPDALNNLRLQDGAGDGPSSSADWNHPEDGDSRSIYVIPAPSIYAREDWLIQVLF
Source in vitro E.coli expression system
Gene Names Dll3
Protein Names Recommended name: Delta-like protein 3 Alternative name(s): Drosophila Delta homolog 3 Short name= Delta3 Short name= M-Delta-3
Expression Region 33-592
Tag Info N-terminal 10xHis-tagged
Protein Description Full Length of Mature Protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.
Involvement in disease A truncating mutation in Dll3 is the cause of the pudgy (pu) phenotype. Pudgy mice exhibit patterning defects at the earliest stages of somitogenesis. Adult pudgy mice present severe vertebral and rib deformities.
Subcellular Location Membrane, Single-pass type I membrane protein
Tissue Specificity Predominantly expressed in the neuroectoderm and paraxial mesoderm during embryogenesis.
Database Links

KEGG: mmu:13389

STRING: 10090.ENSMUSP00000103951

UniGene: Mm.12896

Pathway Notch signaling pathway
Th1 and Th2 cell differentiation

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