Recombinant Mouse Delta-like protein 3(Dll3)

Code CSB-CF006948MO
Size Pls inquire other sizes
Source in vitro E.coli expression system
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Product Details

Target Names Dll3
Uniprot No. O88516
Alternative Names Dll3Delta-like protein 3; Drosophila Delta homolog 3; Delta3; M-Delta-3
Species Mus musculus (Mouse)
Expression Region 33-592
Target Protein Sequence HSFGPGPGLGTPRSPCNARGPCRLFFRVCLKPGVSQEATESLCALGAALSTSVPVYTEHPGESAAALPLPDGLVRVPFRDAWPGTFSLVIETWREQLGEHAGGPAWNLLARVVGRRRLAAGGPWARDVQRTGTWELHFSYRARCEPPAVGAACARLCRSRSAPSRCGPGLRPCTPFPDECEAPSVCRPGCSPEHGYCEEPDECRCLEGWTGPLCTVPVSTSSCLNSRVPGPASTGCLLPGPGPCDGNPCANGGSCSETSGSFECACPRGFYGLRCEVSGVTCADGPCFNGGLCVGGEDPDSAYVCHCPPGFQGSNCEKRVDRCSLQPCQNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGSRRCSCALGFGGRDCRERADPCASRPCAHGGRCYAHFSGLVCACAPGYMGVRCEFAVRPDGADAVPAAPRGLRQADPQRFLLPPALGLLVAAGLAGAALLVIHVRRRGPGQDTGTRLLSGTREPSVHTLPDALNNLRLQDGAGDGPSSSADWNHPEDGDSRSIYVIPAPSIYAREDWLIQVLF
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal 10xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.
Gene References into Functions
  1. Structural deformities of the vertebral column and adjacent ribs in the pudgy mouse are caused by mutations in Dll3. Review. PMID: 27655002
  2. Dll3 overexpression promoted PI3K/Akt signaling through inhibiting Notch signaling in lung cancer. PMID: 28007595
  3. O-fucosylation of DLL3 is required for its function during somitogenesis. PMID: 25856312
  4. Intriguing changes are observed in the cranio-caudal borders of multifidus muscle in mutant Dll3 and Lfng models of idiopathic scoliosis. PMID: 22095884
  5. Dll3 has a unique function during T-cell development that is distinct from the role played by the other DSL ligands of Notch. PMID: 21151194
  6. Dll3 targets Notch1 for lysosomal degradation preventing Notch1 from undergoing post-translational processing. PMID: 21147753
  7. Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm. PMID: 11923214
  8. DLL3 knockout mice have segmentation and neural defects PMID: 12141422
  9. spondylocostal dysostosis (SCD) is caused by mutation in Delta-like 3 (DLL3), Mesoderm posterior 2 (MESP2), and Lunatic fringe (LFNG); three genes that are components of the Notch signaling pathway. PMID: 17600782
  10. study reports that another Notch ligand, Dll3, is expressed in developing hair cells, in a pattern that overlaps that of Dll1 and Jag2; Dll3 may play a role in lateral inhibition similar to that of Dll1 and Jag2 PMID: 17823936
  11. study shows that genetic interactions between Notch1 and Dll3 result in vertebral segmental defects similar to those seen in congenital scoliosis; craniofacial anomalies not previously observed in Dll3 homozygous animals were identified PMID: 17849441
  12. Dll3 are expressed in the developing mouse eye and in retinal progenitor cell. PMID: 19191219
  13. a complex interplay of E-box binding proteins spatially and temporally regulate Dll3 levels during neural tube development. PMID: 19389376
  14. Data show that the ubiquitin ligase Huwe1 operates upstream of the N-Myc-DLL3-Notch pathway to control neural stem cell activity and promote neurogenesis. PMID: 19686682

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Involvement in disease A truncating mutation in Dll3 is the cause of the pudgy (pu) phenotype. Pudgy mice exhibit patterning defects at the earliest stages of somitogenesis. Adult pudgy mice present severe vertebral and rib deformities.
Subcellular Location Membrane, Single-pass type I membrane protein
Tissue Specificity Predominantly expressed in the neuroectoderm and paraxial mesoderm during embryogenesis.
Database Links

KEGG: mmu:13389

STRING: 10090.ENSMUSP00000103951

UniGene: Mm.12896

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