Recombinant Mouse ERBB receptor feedback inhibitor 1 (Errfi1)

1. Study showed that Mig-6 has an important function of tumor suppressor via inhibition of STAT3 phosphorylation in uterine epithelial cells, and the antitumor effects of progesterone are mediated by the endometrial stroma. PMID: 28925396
2. Mig-6 deficiency promotes the development of Kras(G12D)-induced lung adenoma through reducing the cell apoptosis in Kras(G12D) mouse lungs partially by activating the ErbB4 pathway. PMID: 29191600
3. Studies indicate that progesterone receptor transgenic (Pgrcre/+) mitogen inducible gene 6 (Mig-6over) phosphatase and tensin homolog protein (Ptenf/f) knockout mice exhibited an increase of phospho-ERK1/2 and its target genes. PMID: 27910070
4. mouse Mig-6 ablation in the liver results in multiple metabolic phenotypes such as fatty liver, fasting hyperglycemia, and hypercholesterolemia but in lower bodyweight and improved insulin sensitivity. PMID: 28053990
5. Liver-specific ablation of Mig-6 caused hyperglycemia by hepatic insulin resistance. PMID: 25594850
6. MIG6 is a potent tumor suppressor for mutant EGFR-driven lung tumor initiation and progression in mice and provides a possible mechanism by which mutant EGFR can partially circumvent this tumor suppressor in human lung adenocarcinoma. PMID: 25735773
7. This microarray analysis also revealed that 324 genes are regulated by P4 as well as Mig-6. Cited2, the developmentally important transcription factor, was identified as being regulated by the P4-Mig-6 axis PMID: 25976672
8. Mig-6 plays a critical role in the development of atherosclerosis. PMID: 25574067
9. our findings suggest that Mig-6 regulates ERK1/2 phosphorylation and that it is crucial for progression of PTEN-mutant endometrial cancers, providing a mechanistic rationale for the evaluation of ERK1/2 inhibitors PMID: 25377472
10. MIG-6 expression in chondrocytes is important for the maintenance of cartilage and joint homeostasis. PMID: 24966136
11. Cartilage-specific deletion of Mig-6 results in osteoarthritis-like disorder with excessive articular chondrocyte proliferation. PMID: 24550287
12. This treatment had no effect in PR(cre/+)Mig-6(f/f) mice where Mig-6 was deleted in both the epithelial and stromal compartments of the uterus. PMID: 23811943
13. The sustained production of Mig6 protein exacerbates endoplasmic reticulum stress-induced beta-cell death. PMID: 23204325
14. Mig-6 plays a critical role in the regulation of cholesterol homeostasis and bile acid synthesis. PMID: 22912762
15. Mig6 functions as a molecular brake for beta-cell proliferation during glucocorticoid treatment in beta-cells, and thus, Mig6 may be a novel target for preventing glucocorticoid-induced impairments in functional beta-cell mass. PMID: 23384834
16. The Mig6 activates c-Abl by binding to the kinase domain, which is prevented in the presence of epidermal growth factor (EGF) by Src family kinase-mediated phosphorylation on c-Abl-Tyr488. PMID: 22975324
17. multifaceted genomic evaluation of glioblastoma establishes ERRFI1 as a potential candidate tumor suppressor gene and TACC3 as a potential oncogene, and provides insight on targets for oncogenic pathway-based therapy PMID: 21113414
18. results suggest that Mig-6 exerts a tumor-suppressor function in endometrial cancer by promoting epithelial cell apoptosis through the downregulation of the estrogen-induced apoptosis inhibitors Birc1 and the inhibition of ERK2 phosphorylation PMID: 20418913
19. Using Errfi1(d/d) mice, Errfi1 was identified as an important mediator of uterine implantation. Epithelial ESR1 and target genes were significantly increased in the uteri of Errfi1(d/d) mice. PMID: 20018910
20. Mig-6 controls EGFR trafficking and suppresses gliomagenesis PMID: 20351267
21. Mitogen-inducible gene-6 is a negative regulator of epidermal growth factor receptor signaling in hepatocytes and human hepatocellular carcinoma. PMID: 20044804
22. RALT behaves as a suppressor of EGFR signalling in mouse skin PMID: 16007071
23. loss of Mig-6 leads to early onset of joint disease PMID: 16087873
24. The Mitogen-inducible gene 6 negatively regulates HGF/Met-induced cell migration. PMID: 16247031
25. Results indicate that Mig6 is a specific negative regulator of Egfr signaling in skin morphogenesis and is a novel tumor suppressor of Egfr-dependent carcinogenesis. PMID: 16648858
26. Cardiac overexpression of RALT improves cardiac function and inhibits maladaptive hypertrophy, inflammation, and fibrosis through attenuating epidermal growth factor receptor-dependent signaling. PMID: 19204184
27. Mig-6 is a critical regulator of the response of the endometrium to estrogen in regulating tissue homeostasis PMID: 19439667
28. Mig-6 is required for prenatal and perinatal lung development, in part through the regulation of EGF signaling, as well as for maintaining proper pulmonary vascularization. PMID: 19710174

Show More

Hide All

KEGG: mmu:74155

STRING: 10090.ENSMUSP00000030811

UniGene: Mm.318841