Recombinant Mouse FYN-binding protein (Fyb), partial

1. ADAP fulfills different functions in CD4(+) and CD8(+) T cells, with CD8(+) T cells being less dependent on ADAP. PMID: 27605210
2. ADAP regulates CD8 T cell differentiation events following acute pathogen challenge that are critical for the formation and selected functions of TRM cells in nonlymphoid tissues. PMID: 27521337
3. Data (including data from studies in knockout/transgenic mice) suggest that ADAP regulates positive feedback loop of TGFbeta1 production and TGFbeta1-induced CD103 expression in CD8+ T-lymphocytes and protects against influenza H5N1 virus infection. PMID: 25909459
4. The results indicate that ADAP dampens naive CD8 T cell responses to lymphopenia and IL-15, and they demonstrate a novel Ag-independent function for ADAP in the suppression of memory phenotype CD8 T cell generation. PMID: 26320248
5. ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding. PMID: 24523237
6. we demonstrate that loss of ADAP promotes resistance of experimental autoimmune encephalomyelitis in mice, likely by trapping encephalitogenic T cells in the peripheral lymph nodes on LYVE-1+ lymphatic structures. PMID: 24101551
7. Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells. PMID: 24036998
8. integrin activation by the ADAP-SKAP55-signaling module controls the stability and duration of T cell-dendritic cell contacts during the progressive phases necessary for optimal T cell activation. PMID: 23918975
9. ADAP coordinates distinct CARMA1-dependent control of key cell cycle proteins in T cells PMID: 22411628
10. The authors utilize in vitro systems to map novel phosphotyrosine sites in the C-terminal part of human ADAP (486-783). They found many phospho-dependent binding partners of ADAP and confirmed the interaction between ADAP and Nck, indicating that ADAP directly links integrins to modulators of the cytoskeleton independent of SLP-76. PMID: 20661443
11. ADAP plays a role in mediating platelet activation via the collagen-binding integrin alpha(2) beta(1). PMID: 22103309
12. SLP-76 and ADAP are involved in E-selectin-mediated integrin activation and neutrophil recruitment to inflamed kidneys, which may underlie the development of life-threatening ischemia-reperfusion-induced acute kidney injury in humans. PMID: 22291096
13. TM4SF10, possibly through ADAP, may regulate Fyn activity PMID: 21881001
14. Data suggest that the presence or absence of associated SKAP55 defines functionally distinct pools of ADAP. PMID: 21525391
15. HPK1 competes with ADAP for SLP-76 binding and via Rap1 negatively affects T-cell adhesion. PMID: 20957749
16. the ADAP CARMA1 binding site is required for IKK gamma ubiquitination; both TAK1 and CARMA1 binding sites are required for IkappaB alpha phosphorylation and degradation and NF-kappaB nuclear translocation PMID: 20164171
17. ADAP is an essential component of alphaIIbbeta3-mediated platelet mechanotransduction that promotes F-actin assembly and enables platelet spreading and thrombus stabilization under fluid shear stress. PMID: 19996090
18. ADAP-SLP-76 binding as a signaling event that differentially regulates SMAC formation, and support a role for SMAC formation in T cell cytokine production. PMID: 15477347
19. mammalian actin binding protein 1 is likely to constitute a downstream effector of Fyb involved in F-actin dynamics PMID: 15848169
20. May play an important role as a partner of c-Src for cell migration and progression to the multinucleated cell stage in osteoclastogenesis in vitro. PMID: 16020549
21. ADAP plays a critical role in several phases of thymocyte development and selection. PMID: 16709827
22. ADAP-deficient mice show no defects in NK development. Further, ADAP is dispensable for key NK functions, including cytotoxicity in response to engagement of activating receptors, cytokine production, conjugate formation and tumor suppression in vivo. PMID: 16775024
23. A signaling module comprising the cytosolic adapter proteins ADAP and SKAP55 is involved in TCR-mediated inside-out signaling and, the interaction between ADAP and SKAP55 is mandatory for integrin activation. PMID: 16980616
24. ADAP's role in GP Ib-IX-V signal transduction. PMID: 17003372
25. findings provide new insights into ADAP function and the mechanism by which CARMA1 regulates NF-kappaB activation in T cells PMID: 17478723
26. although ADAP is dispensable for the rejection of allografts, ADAP function plays an important role for the efficacy of graft rejection; ADAP's main function appears to affect the induction phase of the immune response. PMID: 17700167
27. ADAP is required for optimal T cell clonal expansion to low doses of antigen in vivo under conditions of high clonal abundance. PMID: 17785790
28. inefficient positive selection in ADAP deficiency results in lymphopenia that leads to enhanced autoimmune diabetes in the BDC/B6g7/b model PMID: 18383041
29. A small region of the ADAP proline-rich domain is required for rescue of SKAP55 expression by ADAP-deficient T cells, as well as for optimal antigen-dependent T cell:antigen presenting cell conjugate formation and downstream T cell activation. PMID: 18802088
30. Findings provide evidence of an obligatory role for the SLP-76-ADAP module in LFA-1-mediated costimulation in T cells. PMID: 19617540
31. Important for coupling TCR-mediated actin cytoskeletal rearrangement with activation of integrin function and for T cells to respond fully to activating signals. PMID: 11567141
32. Regulates TCR-induced integrin clustering and adhesion. PMID: 11567140

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KEGG: mmu:23880

STRING: 10090.ENSMUSP00000087947

UniGene: Mm.170905