Recombinant Mouse Fibroblast growth factor receptor substrate 2 (Frs2)

1. FRS2alpha-mediated pathways are essential for the FGF15/FGF19-FGFR4 signaling axis to control bile acid homeostasis. PMID: 25056539
2. controlsConclusionFrs2alpha(ST-/-) embryos have aberrant ureteric induction sites, improper ureteral insertion, shortened intravesicular lengths, and VUR PMID: 29135976
3. Embryonic day 18.5 Six2Frs2alphaKO kidneys were hypoplastic and not cystic, postnatal day (P) 7 mutants had proximal tubular-derived cysts that nearly replaced the renal parenchyma by P21. Mutants had high proximal tubular proliferation rates and interstitial fibrosis, similar to known polycystic kidney disease models. PMID: 27853247
4. Fgfr signaling in nephron progenitors appears to be mediated predominantly by Frs2alpha. PMID: 25641696
5. Analysis of a mutant Fgfr1 allele, unable to bind to the adaptor protein, Frs2/3, indicates that Sox2 maintenance can be regulated by MAP kinase. PMID: 24465223
6. data from two models showed that FRS2 played different roles in the regulation of two activity levels of the ERK pathway components in the epididymis. PMID: 23782834
7. Genetic evidence further supports that the formation of an Frs2alpha-Shp2 complex and its recruitment to FGF receptors are crucial for downstream ERK signaling in this process. PMID: 23720040
8. Frs2alpha enhances fibroblast growth factor-mediated survival and differentiation in lens development. PMID: 23136392
9. a novel signaling network containing FRS2, CAP and flotillin-1 PMID: 22235335
10. FRS2alpha-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity. PMID: 22207710
11. The FGF signaling axis activates mTOR via the FGF receptor substrate 2alpha (FRS2alpha)-mediated PI3K/Akt pathway, and suppresses autophagy activity in MEFs. PMID: 21927580
12. although Fgfr2 and Frs2alpha have crucial roles in the ureteric lineage, they appear to act separately and additively. PMID: 21350013
13. Msx2 and Runx2 likely function together to induce PC-1 gene expression in osteoblastic cells and FGF signaling stimulates Msx2 transcriptional activity through the Frs2 mediated MAPK signaling pathway PMID: 20803545
14. FRS2alpha fine-tunes the FGF2-signaling to control self-renewal and proliferation of neural stem cells through Hes1. PMID: 20652960
15. Data show that PEA-15 prevents ERK1/2 localization to the plasma membrane, thereby inhibiting ERK1/2-dependent threonine phosphorylation of FRS2alpha to promote activation of the ERK1/2 MAP kinase pathway. PMID: 20032303
16. Trophoblast stem cell FRS2alpha mediates activation of the ERK pathway to enhance Cdx2 expression in response to FGF4. Cdx2 in turn binds to an FGF4-responsive enhancer element of the promoter region of Bmp4, leading to production and secretion of Bmp4. PMID: 19890878
17. Frs2alpha and Frs2beta have distinct spatio-temporal expression patterns in mouse embryos PMID: 15094036
18. FGFR kinase regulates the cell cycle through phosphorylation-dependent release of Cks1 from FGFR substrate 2 PMID: 15513912
19. FRS2-dependent SRC activation is required for FGFR-induced phosphorylation of Sprouty and suppression of ERK activity PMID: 15564375
20. explore the role of signaling pathways downstream of FRS2alpha in eye development by analyzing the phenotypes of mice that carry point mutations in either the Grb2-or the Shp2-binding sites of FRS2alpha PMID: 15569927
21. experiments underscore the critical role of FRS2alpha in mediating multiple processes during embryonic development and reveal a potential new link between FGF and Bmp4 signaling pathways in early embryogenesis PMID: 15870281
22. Shp2-binding sites on FRS2alpha play an important role in neural progenitor cells (NSPC) proliferation but are dispensable for NSPC self-renewing capacity after FGF2 stimulation PMID: 16239343
23. Generation of an Frs2alpha conditional null allele. PMID: 17868091
24. Results suggest that although the tyrosine autophosphorylation sites of FGFR1 did not constitute the binding sites for FRS2alpha, phosphorylation of these residues was essential for optimal interaction with FRS2alpha. PMID: 17901128
25. The number of carotid sinus nerve fibers that reached the carotid bifurcation region was markedly decreased, and baroreceptor fiberswere absent from the basal part of the internal carotid artery in FRS2 alpha(2F/2F) mutant mice. PMID: 18177855
26. FRS2alpha is uniformly expressed in the epithelial cells of developing prostates, whereas it is expressed only in basal cells of the mature prostate epithelium. PMID: 18184727
27. an important function for FRS2 is to concentrate RET in membrane foci, leading to an engagement of specific signaling complexes localized in these membrane domains PMID: 18189271
28. FRS2alpha (FRS2), an adaptor protein that links FGF receptor kinases to multiple signaling pathways, mediates crucial aspects of fibroblast growth factor-dependent outflow tract development in mouse. PMID: 18832393
29. role in development and growth of neural progenitor cells PMID: 19149625
30. separation, migration, and survival of the pharyngeal organs were impaired in the FRS2alpha(2F/2F) mutants PMID: 19235715
31. the renal hypoplasia observed in Frs2alpha(UB-/-) mice is likely secondary to decreased Ret and Wnt11 expression PMID: 19741018

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KEGG: mmu:327826

STRING: 10090.ENSMUSP00000020381

UniGene: Mm.135965