Recombinant Mouse Low-density lipoprotein receptor-related protein 8 (Lrp8), partial

1. The data of the present study demonstrated that the PCSK9 shRNAmediated antiapoptotic effect induced by MCAO in hyperlipidemic mice is associated with ApoER2 downregulation, which may be a potential new therapy for stroke treatment in patients with hyperlipidemia. PMID: 30066942
2. Stage-specific labeling of newborn Apoer2-deficient neurons revealed that the neurons ectopically invaded the marginal zone and that neuronal migration of both early- and late-born neurons was disrupted in the intermediate zone in the Apoer2 KO mice. Rescue experiments showed that ApoER2 functions both in cell-autonomous and noncell-autonomous manners. PMID: 27909010
3. GRIP1 binds to apoER2 and EphrinB2 to induce activity-dependent AMPA receptor insertion at the synapse. PMID: 28978486
4. A1-A1, which is a soluble analog of ApoER2 that binds pathological beta2GPI/anti-beta2GPI complexes, has a positive impact on hemodynamics in lupus-prone mice with spontaneous anti-beta2GPI antibodies and hypertension PMID: 26990752
5. findings indicate that impaired processing or localization of apoER2 may contribute to the pathogenic effects of familial Alzheimer's disease mutations in PS1 PMID: 27810638
6. reveals a novel function for Reelin/ApoER2 in peripheral nervous system, inducing cell migration of Schwann cells, a process relevant for peripheral nervous system development and regeneration PMID: 26386179
7. total levels of ApoER2 and surface levels of ApoER2 are increased by active Fyn PMID: 25340851
8. This study demonstrated that ApoER2 is expressed in distinct spatiotemporal patterns in developing mouse cerebral cortex. PMID: 25308109
9. This study demonistrated that LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation in mice. PMID: 25892301
10. Apoer2 lacking exon 16, the O-linked sugar domain, altered the proteolytic processing and abundance of Apoer2 in cells and synapse number and function in mice, hippocampal spine density, LTP, and cued fear learning. PMID: 25429077
11. genetic variants of apoE and ApoER2 impact cardiovascular health by differentially modulating endothelial function. PMID: 25197062
12. Tandem Sepp1-apoER2 interactions supply selenium for maintenance of brain neurons both at the blood-brain barrier and within the brain. Sepp1 inside the blood-brain barrier is taken up by neurons via apoER2, concentrating brain selenium in them. PMID: 24760755
13. data demonstrate that several multivalent ligands for ApoER2 induce clustering in transfected cells and primary neurons and that these complexes included other synaptic molecules, such as APP and PSD-95 PMID: 24755222
14. Apolipoprotein E receptor-2 deficiency enhances macrophage susceptibility to lipid accumulation and cell death to augment atherosclerotic plaque progression and necrosis. PMID: 24840660
15. longer isoforms of Sepp1 with high selenium content interact with a binding site distinct from the ligand-binding domain of apoER2 for selenium delivery PMID: 24532792
16. Clusterin is a ligand for apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR) and signals via the Reelin-signaling pathway. PMID: 24381170
17. The Reelin receptors ApoER2 and VLDLr play essential roles in Reelin-mediated migration and positioning of mesencephalic dopaminergic neurons. PMID: 23976984
18. Dab1 mediated the association of CIN85 with ApoER2 or VLDLR in neurons. PMID: 23506116
19. there are reelin-independent functions of very-low-density lipoprotein receptor (VLDLR) and low-density lipoprotein receptor-related protein 8 in geniculate nucleus development. PMID: 23758727
20. Data indicate that uptake of Sepp1 and Gpx3 by d-13 visceral yolk sac was independent of apoER2 and megalin. PMID: 23651543
21. Data show identified ApoER2 as being the main receptor responsible for Reelin mediated detachment of neuroblasts and correct migration of early generated interneurons within the OB, a prerequisite for correct OB lamination. PMID: 23209795
22. These results identify LRP8 as a novel positive factor of canonical Wnt signaling pathway. PMID: 22589174
23. apoER2-mediated uptake of long isoform Sepp1 is responsible for selenium distribution to tissues throughout the body. PMID: 22761431
24. ApoEr2 plays important roles in structure and function of CNS synapses and dendritic spines PMID: 21347244
25. activation of VLDLR and apoER2 by reelin and apoE induces ABCA1 expression and cholesterol efflux via a Dab1-PI3K-PKCzeta-Sp1 signaling cascade. PMID: 22170052
26. ApoER2 plays a pivotal role in the development of the rod bipolar pathway and maintenance of retinal synaptic connectivity. PMID: 21976526
27. Apolipoprotein E receptor-2 deficient transgenic mice fed a selenium-deficient diet become neurologically dysfunctional and do not survive. PMID: 17553992
28. ApoER2 is involved in pathogenesis of antiphospholipids antibodies. PMID: 21119114
29. Reelin activates the Rho GTPase Cdc42, known for its role in neuronal morphogenesis and directed migration, in an ApoER2-, Disabled-1-, and phosphatidylinositol 3-kinase-dependent manner. PMID: 21048135
30. Data show that the identification of VLDLR and ApoER2 as Idol(Mylip) targets suggests potential roles for this LXR-inducible E3 ligase in the central nervous system in addition to lipid metabolism. PMID: 20427281
31. One APOER2 isoform has 4 binding repeats & an adjacent short 13 AA insertion with a furin cleavage site. The resulting receptor fragment (the entire ligand-binding domain is secreted as soluble polypeptide) inhibits Reelin signaling in primary neurons. PMID: 12426372
32. Reelin receptor machinery, including ApoER2 and VLDLR and Dab1 protein, is located in radial glia precursors in cortical wall from the ventricular zone to the pial surface. PMID: 12586425
33. apoER2 is highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation PMID: 12695510
34. Apolipoprotein E receptors activate p42/44 MAPK and have roles in neurite outgrowth PMID: 15169786
35. Reelin treatment targets adaptor protein Disabled-1(Dab1) for proteolytic degradation by the ubiquitin-proteasome pathway and signaling through neuronal apolipoprotein E receptor 2 can activate the ubiquitin-proteasome machinery PMID: 15175346
36. binding of LDL to platelets resulted in tyrosine phosphorylation of apoER2' PMID: 15459198
37. Reelin binds several receptors. including LrpB ini cultured hippocampux neurons. PMID: 15987942
38. Thus, alternative splicing of Apoer2, a novel component of the NMDA receptor complex, controls the modulation of NMDA receptor activity, synaptic neurotransmission, and memory by Reelin. PMID: 16102539
39. ApoEr2 coprecipitated with APP alpha- and beta-CTF, and F-spondin reduced the levels of APP intracellular domain signaling. PMID: 16227578
40. ApoEr2 can form a multiprotein complex with NMDA receptor subunits and PSD95 PMID: 16332682
41. platelets adhere to dimeric beta2GPI under both arterial and venous shear stresses. Platelets adhere via two receptors: GPIbalpha and apoER2'. These receptors are present in a complex on the platelet surface PMID: 17096706
42. Study demonstrates that a differentially spliced isoform of ApoE receptor 2 (Apoer2), is essential for protection against neuronal cell loss during normal aging. PMID: 17174920
43. Sertoli cell ApoER2 is a Sepp1 receptor and a component of the selenium delivery pathway to spermatogenic cells PMID: 17314095
44. These data demonstrate a cell-autonomous function of ApoER2, and most likely VLDLR and Dab1, in postnatal migration of neuroblasts in the forebrain, which is suggested to depend on ligands other than Reelin. PMID: 17494763
45. ApoER2 knockout mice also displayed altered use of specific search strategies in the maze PMID: 17907841
46. present evidence for divergent roles of the two reelin receptors Vldlr and ApoER2, with Vldlr mediating a stop signal for migrating neurons and ApoER2 being essential for the migration of late generated neocortical neurons PMID: 17913789
47. the activity of PCSK9 and its binding affinity on VLDLR and ApoER2 does not depend on the presence of LDLR. PMID: 18039658
48. Fyn, due in part to its effects on Dab1, regulates the phosphorylation, trafficking, and processing of APP and apoEr2. PMID: 18089558
49. Neurodegeneration in mice resulting from loss of functional apolipoprotein E receptor 2. PMID: 18172410
50. The plasticity associated with the Reelin-Apoer 2-exon 19 pathway is distinct from that which contributes to injury-induced enhancement of 'pain' processing. PMID: 18279306

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UniGene: Mm.442134