Recombinant Mouse Metabotropic glutamate receptor 6 (Grm6), partial

Code CSB-YP708840MO
MSDS
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Source Yeast
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Code CSB-EP708840MO
MSDS
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Source E.coli
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Code CSB-EP708840MO-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP708840MO
MSDS
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Source Baculovirus
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Code CSB-MP708840MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Grm6
Uniprot No.
Alternative Names
Grm6; Gprc1f; Mglur6Metabotropic glutamate receptor 6; mGluR6
Species
Mus musculus (Mouse)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision.
Gene References into Functions
  1. Laminar size and structure in missense Grm6(nob8) retina were comparable to control. The Grm6(nob8) phenotype is distinguished from other Grm6 mutants that carry a null allele by a reduced but not absent electroretinograph b-wave, decreased but present expression of mGluR6 at retinal depolarizing bipolar cells (DBCs) dendritic tips, and mislocalization of mGluR6 to DBC somas. In p.Met66Leu mutant mGluR6 is trafficked less PMID: 28490646
  2. Study suggests that the mGluR6 macromolecular complex is connected to the presynaptic rod terminal via a protein chain that includes the matrix-associated proteins. When a component of the macromolecular chain is missing, the chain may fall apart and loosen the dendritic tip adherence within the invagination. PMID: 27037829
  3. These results indicate that Grm6 nob7 is a new model of the complete form of congenital stationary night blindness. PMID: 26241901
  4. The mGluR6-KO phenotype showed negative effects on ribbon synapse formation. PMID: 24801622
  5. Diagnosis of concurrent Stargardt disease and CSNB was made on the ophthalmic history; genetic testing revealed two previously reported mutations in the ABCA4 gene and two novel deletions in the GRM6 gene. PMID: 24397708
  6. the localization and stability of Cacna1s depend on the expression of mGluR6 and its cascade components, and they suggest that Cacna1s is part of the mGluR6 complex. PMID: 24519419
  7. The results suggested that the TRPM1 channel in metabotropic glutamate receptor 6-null rod bipolar cells is inactive. Rod bipolar cells in metabotropic glutamate receptor 6-null mice were hyperpolarized. PMID: 22131384
  8. These results demonstrate that TRPM1-L is a component of the ON bipolar cell (BC) transduction channel downstream of mGluR6 in ON BCs. PMID: 19966281
  9. The mGluR6 mRNA levels are altered in the young and adult rat retina of Royal College of Surgeons rat and suggest that the genetically induced degeneration of photoreceptors affects the expression of this receptor by the INL retinal neurons. PMID: 16213654
  10. In mGluR6-null mice, long-latency ON responses are observed in the visual cortex, indicating that they can be conducted reliably to higher visual areas. PMID: 17108159
  11. mGluR6 expression was limited to the outer plexiform layer PMID: 17311335
  12. Mutation is similar to that of human patients with congenital stationary night blindness and will provide a tool for understanding retinal circuitry. PMID: 17430614
  13. Visual responses of Grm6(no b-wave3) retinal ganglion cells to light onset were abnormal. PMID: 18687716
  14. Obesity and hyperglycemia of New Zealand obese mice is to a large part caused by variant genes located in Nob3 on chromosome 1. PMID: 19470805

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Subcellular Location
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell projection, dendrite.
Protein Families
G-protein coupled receptor 3 family
Tissue Specificity
Detected in the outer plexiform layer in retina (at protein level).
Database Links
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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