Recombinant Mouse Myocyte-specific enhancer factor 2A (Mef2a)

1. Canonical pathway analysis of genes preferentially dysregulated in the atria and ventricles revealed distinct MEF2A-dependent cellular processes in each cardiac chamber. In the atria, MEF2A regulated genes involved in fibrosis and adhesion, whereas in the ventricles, it controlled inflammation and endocytosis. PMID: 29054930
2. Both synapse silencing and elimination required de novo transcription, but only silencing required the activity-dependent transcription factors MEF2A/D. PMID: 28901289
3. Deficiency of AKT2 in myocardium results in diminished MEF2A abundance, which induced decreased size of cardiomyocytes. We additionally confirmed that EndoG, which is also regulated by AKT2, is a suppressor of MEF2A in myocardium. PMID: 28965945
4. Nuclear HDAC4 binds to chromatin as well as to MEF2A transcription factor, leading to histone deacetylation and altered neuronal gene expression. By using a Cdkl5 knockout (Cdkl5 -/Y) mouse model, we found that hypophosphorylated HDAC4 translocates to the nucleus of neural precursor cells, thereby reducing histone 3 acetylation. PMID: 27466189
5. Knockdown of MEF2A significantly reduced hyperglycemia-induced cardiac fibroblast proliferation and migration, myofibroblast differentiation, matrix metalloproteinase activities, and collagen production. PMID: 26482596
6. Lentivirus-mediated MEF 2A shRNA accelerates inflammation and atherosclerosis in APOE knockout mice, but has no effect on lipoprotein levels in plasma. PMID: 25793529
7. microRNAs encoded by the Gtl2-Dio3 noncoding RNA locus function downstream of the MEF2A PMID: 26240138
8. Our results indicated that exercise-induced CPT1b expression was at least in part mediated by HDAC5/MEF2A interaction. PMID: 25213552
9. MEF2A is targeted to lysosomes for chaperone-mediated autophagy degradation; oxidative stress-induced lysosome destabilization leads to the disruption of MEF2A degradation as well as the dysregulation of its function PMID: 24879151
10. Whereas MEF2A is absolutely required for proper myoblast differentiation, MEF2B, -C, and -D were found to be dispensable for this process. PMID: 25416778
11. A role for endogenous MEF2 factors exclusively in hormone/Fsk/cAMP-induced Nr4a1 gene expression in mouse MA-10 Leydig cells. PMID: 24694307
12. Combined deletion of the Mef2a, c, and d genes results in a blockade to muscle regeneration. PMID: 24591619
13. Cross-talk between p38MAPK and GSK3beta signaling converges on MEF2 activity. PMID: 23137781
14. Myocyte enhancer factor 2A (MEF2A) controls skeletal muscle regeneration in adult mice through direct regulation of the largest known mammalian microRNA (miRNA) cluster, the Gtl2-Dio3 locus. PMID: 23154418
15. These results give novel insight into the molecular interplay of GR and MEF2 in the control of genes important for neuronal plasticity. PMID: 22622902
16. MEF2A, but not MEF2C or MEF2D, is modified by ubiquitination in dopaminergic neuronal cell line SN4741 cells. PMID: 22764880
17. The data highlighted the key in vivo role of MEF2C isoform in the brain and suggest that MEF2A and MEF2D have only subtle roles in regulating hippocampal synaptic function. PMID: 22496871
18. establish miR-155 as an important regulator of MEF2A expression and uncover its function in muscle gene expression and myogenic differentiation. PMID: 21868385
19. Exercise increases the nuclear MEF2A content and binding of MEF2A to their binding sites on the Glut4 gene by an AMPKalpha2-dependent mechanism. PMID: 21233771
20. The Mef2A transcription factor coordinately regulates a costamere gene program in cardiac muscle. PMID: 21724844
21. A systems biology study integrating mRNA profiles with DNA-binding events of key cardiac transcription factors (Gata4, Mef2a, Nkx2.5, and Srf), activating histone modifications (H3ac, H4ac, H3K4me2, and H3K4me3), and microRNA profiles, is reported. PMID: 21379568
22. ZAC1 is a novel and previously unknown regulator of cardiomyocyte Glut4 expression and glucose uptake; MEF2 is a regulator of ZAC1 expression in response to induction of hypertrophy PMID: 20363751
23. active MEF2 and fragile X mental retardation protein function together in an acute, cell-autonomous mechanism to eliminate excitatory synapses. PMID: 20434996
24. Reveal a novel MEF2A-Xirp2 pathway that functions downstream of Ang II signaling to modulate its pathological effects in the heart. PMID: 20093629
25. TGF-beta transcriptionally upregulated MMP-10 through activation of MEF2A, concomitant with acetylation of core histones increasing around the promoter, as a consequence of degradation of the class IIa HDACs. PMID: 19935709
26. Dermo-1, a multifunctional basic helix-loop-helix protein, represses MyoD transactivation via the HLH domain, MEF2 interaction, and chromatin deacetylation PMID: 11809751
27. deficient mice suffered sudden cardiac death PMID: 12379849
28. MEF2A expression is regulated by BMP-2-induced PI 3-kinase signaling PMID: 12663654
29. Calcineurein regulates skeletal muscle differentiation by activating MEF2 and MyoD transcription factors. PMID: 12694204
30. MEF2 has a role in maintaining GLUT4 in adult muscle and cooperates with MyoD transcription factors and thyroid hormone receptors in regulating GLUT4 in regenerating muscle PMID: 12893821
31. GEF and MEF2A have roles in regulating the GLUT4 promoter PMID: 14630949
32. MEF2A is induced by CUGPB-1 and along with p21, it inhibits myogenesis and contributes to the development of muscle deficiency myotonic dystrophy PMID: 14722059
33. Data show that static stretch application produces a robust increase in p38 phosphorylation preceding MEF2A, but not NFATc1, nuclear translocation. PMID: 15483225
34. MEF2 has a role in regulating genes during muscle differentiation PMID: 15507520
35. Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo PMID: 15728583
36. A conserved pattern of alternative splicing in vertebrate MEF2 (myocyte enhancer factor 2) genes generates an acidic activation domain in MEF2 proteins selectively in tissues where MEF2 target genes are highly expressed. (MEF2) PMID: 15834131
37. MEF2/HAND1 interaction results in synergistic activation of MEF2-dependent promoters, and MEF2 binding sites are sufficient to mediate this synergy PMID: 16043483
38. MEF2A up-regulates myospryn at the costamere in striated muscle potentially playing a role in myofibrillogenesis. PMID: 16407236
39. MEF2 transcription factors in the postnatal heart activate a genetic program that minimally affects cardiac growth yet promotes chamber dilation, mechanical dysfunction, and dilated cardiomyopathy. PMID: 16847152
40. Myomaxin functions directly downstream of MEF2A at the peripheral Z-disc complex in striated muscle potentially playing a role in regulating cytoarchitectural integrity PMID: 17046827
41. Differences in GLUT4 transcription when whole adipose tissue and cell culture model systems are compared can be correlated to a posttranslational phosphorylation of the transcription factor MEF2A. PMID: 17164432
42. ataxin-1 antagonizes the neuronal survival function of myocyte enhancer factor-2 PMID: 17646162
43. SOST expression in osteocytes of adult bone and its inhibition by PTH is mediated by MEF2A, C, and D transcription factors controlling the SOST bone enhancer. PMID: 17696759
44. MEF2 has a central role as a regulator of the transcriptional and posttranscriptional pathways that control cardiac and skeletal muscle development PMID: 18093911
45. GLUT4 enhancer factor (GEF) interacts with MEF2A and HDAC5 to regulate the GLUT4 promoter in adipocytes. PMID: 18216015
46. These findings support a role for MEF2A as an intermediary in coordinating respiratory chain subunit expression in heart and muscle through a NRF1 --> MEF2A --> COX(H) transcriptional cascade. PMID: 18222924
47. miR-1 regulates cardiomyocyte growth responses by negatively regulating the calcium signaling components calmodulin, Mef2a, and Gata4 PMID: 19188439

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KEGG: mmu:17258

STRING: 10090.ENSMUSP00000117496

UniGene: Mm.132788