Recombinant Mouse Myocyte-specific enhancer factor 2D (Mef2d)

1. In the Mef2d heterozygous retina, NRF2 is not up-regulated to a normal degree in the face of light-induced oxidative stress, contributing to accelerated photoreceptor cell death. PMID: 28461502
2. This study identifies MEF2D as a critical regulator of IL-10 gene expression that negatively controls microglia inflammation response and prevents inflammation-mediated cytotoxicity. PMID: 25890150
3. Mef2d is essential for the maturation and integrity of retinal photoreceptor and bipolar cells PMID: 25757744
4. miR-103 worked through activating AKT/mTOR signal pathway and impairing target gene MEF2D. PMID: 25400071
5. These findings demonstrate that broadly expressed TFs acquire specific functions through competitive recruitment to enhancers by tissue-specific Mef2d and through selective activation of these enhancers to regulate tissue-specific genes. PMID: 25801704
6. Oxidation of survival factor MEF2D inhibits its function, underlies oxidative stress-induced neurotoxicity, and may be a part of the Parkinson disease pathogenic process. PMID: 24219011
7. Results demonstrate that coordinated alternative splicing by a single RNA binding protein modulates transcription (Mef2d) and cell signaling (Rock2) programs to drive tissue-specific functions (cell fusion) to promote a developmental transition. PMID: 25087874
8. We found that Parkinson's disease -associated neurotoxins destabilize MEF2D mRNA and reduce its level in vitro and in vivo. PMID: 24848448
9. The resultsof this study showed that MEF2D is a substrate for phosphorylation by ATM, thus promoting survival in response to DNA damage. PMID: 24672010
10. This study identified lysine-267 as a methylation/demethylation site and demonstrated that the lysine methylation state of MEF2D regulates its transcriptional activity and skeletal muscle cell differentiation. PMID: 24078251
11. results reveal a novel mechanism in which a tissue-specific alternate splicing event has evolved that permits a ubiquitously expressed transcription factor, Mef2d, to escape inhibitory signaling for temporal regulation of gene expression PMID: 23723416
12. the inactivation of Nur77, induced by loss of MEF2 activity, plays a critical role in nigrostriatal degeneration in vivo PMID: 23536182
13. Expression of myogenin is regulated, at least in part, by the decreased glycosylation-dependent recruitment of Mef2D to the promoter region, and this is one of the negative regulatory mechanisms of skeletal myogenesis by O-GlcNAc glycosylation. PMID: 23523791
14. Activation of transcription factor MEF2D by bis(3)-cognitin protects dopaminergic neurons and ameliorates Parkinsonian motor defects. PMID: 22891246
15. direct regulation of complex I by mitochondrial MEF2D underlies its neuroprotective effects, and dysregulation of this pathway may contribute to Parkinson disease PMID: 21393861
16. IGF-I blocks the degradation of MEF2D and enhances recovery of MEF2 activity by protecting MEF2D from caspase-dependent cleavage during apoptosis. PMID: 14710356
17. These results demonstrate the importance of the Emb-MEF2D-histone transacetylase p300 complex in the transcriptional regulation of the cardiac actin gene and suggest a potential role in chromatin remodeling associated with muscle gene activation. PMID: 15024082
18. histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications regulate MEF2 PMID: 16166628
19. MEF2 is critical for dopaminergic loss because "cdk5 phosphorylation site mutant" of MEF2D provides neuroprotection in an MPTP mouse model of Parkinson disease. Calpain-p35-p25/cdk5-mediated inactivation of MEF2 plays a critical role in this loss in vivo. PMID: 16407541
20. myogenin specifies the muscle phenotype by cooperating with Mef2D to recruit an ATP-dependent chromatin-remodeling enzyme that alters chromatin structure at regulatory sequences to promote terminal differentiation. PMID: 16424906
21. These findings demonstrate calcium-ionophore-induced activation of the beta MyHC promoter by NFATc1, MyoD, MEF-2D, and p300 in a calcineurin-dependent manner. PMID: 17111365
22. These results reveal an unexpected role for HDAC3 and suggest a novel pathway through which MEF2 activity is controlled in vivo. PMID: 17158926
23. a unique and important function for MEF2D in stress-dependent cardiac growth and reprogramming of gene expression in the adult heart. PMID: 18079970
24. MEF2D is a primary target of PKA signaling in myoblasts that leads to inhibition of the skeletal muscle differentiation program. PMID: 18299387
25. study found chaperone-mediated autophagy regulated the activity of MEF2D; MEF2D was observed to shuttle to the cytoplasm, interact with the chaperone Hsc70 & undergo degradation; MEF2D levels were increased in brains of alpha-synuclein transgenic mice PMID: 19119233

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KEGG: mmu:17261

STRING: 10090.ENSMUSP00000001455

UniGene: Mm.28184