Recombinant Mouse Nuclear transcription factor Y subunit alpha (Nfya)

1. Data show that nuclear factor Y (NF-Y) binds to the inverted CCAAT element (ICE) in the Fatty acid synthase (Fasn) promoter specifically in refeeding states. PMID: 28281280
2. findings may point to a possible role of NF-YA in stress conditions that occur in chronic obesity, ER stress might be involved in the pathogenesis of obesity through NF-YA depletion. PMID: 27837431
3. we conclude that NF-Y and YY1 are important for the basal transcription of Pcyt2 and that NF-Y is involved in the inhibitory effects of 25-HC on Pcyt2 transcription. PMID: 26310456
4. these results indicate that the transcription factor NF-Y regulates the proximal promoter activity of mouse Col11a1 gene in chondrocytes PMID: 24092017
5. these results raise an exciting possibility that targeting CDK1 or NF-Y in the diseased heart may inhibit fibrosis and subsequently confer cardioprotection. PMID: 24477232
6. NF-Ya is a functional activator of Bmal1 transcription and it cooperates with Sp1 and Rev-Erbalpha to generate the daily cycle of Bmal1 expression. PMID: 24030830
7. NF-Y belongs to the restricted circle of transcription factors that govern mouse embryonic stem cells, and that NF-YAs is the active isoform in these cells. PMID: 22969033
8. Sp1, CREB, HNF-1, and NF-Y, known to be responsive to hormones and diet, regulate NAGS transcription PMID: 22383952
9. results indicate nuclear transcription factor NF-Y as a pivotal upstream participant in a regulatory network necessary for the preservation of cycling hematopoietic stem cell. PMID: 22072554
10. Findings establish that NF-Y acts upstream of E2F1 in p53-mediated apoptosis. PMID: 20952509
11. Transcriptional regulation of myeloid differentiation primary response (MyD) genes during myeloid differentiation is mediated by nuclear factor Y. PMID: 12070012
12. NF-Y recruits RNAPII and general transcription factors onto various CCAAT box-containing promoters to permit strong transcriptional activation independently of histone modifications PMID: 15601870
13. NF-Y can stimulate or repress the FGF-4 promoter in an enhancer-dependent manner PMID: 16128003
14. NF-Y activation by TGF-beta1 involves ERK1/2 and potentially an interplay between MAPK pathways, thereby opening the possibility for finely tuned transcriptional regulation PMID: 16434965
15. NF-Y binds to the promoter and/or within the coding region. NF-Y is embedded in positive & negative methyl histone marks, serving a dual function in transcriptional regulation, as an activator or as a repressor. PMID: 18212061
16. Sequestration of NF-YA component to mutant huntingtin aggregates in model mouse brain results in the reduction of HSP70 gene transcription. PMID: 18288205
17. These data indicate a role of NF-Y in modulating the structure and transcriptional competence of chromatin. PMID: 18431504
18. NF-Y is a fundamental switch at the heart of decision between gene activation and repression in CCAAT regulated genes. PMID: 18446193
19. results demonstrate that interaction of NF-Y at the CCAAT box is pivotal to FGFR2 gene transcription partly through the construction of a local open chromatin configuration across the promoter PMID: 19047043

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KEGG: mmu:18044

STRING: 10090.ENSMUSP00000043909

UniGene: Mm.4929