Recombinant Mouse Omega-3 fatty acid receptor 1 (O3far1), partial

1. FFAR4 is differentially expressed and correlated to cytokine expressions in peritoneal macrophages and alveolar macrophages from BALB/c mice. PMID: 29595453
2. Ovarian hormones may directly regulate GPR120 expression in the reproductive cycle at the pituitary level. PMID: 28824022
3. this is the first animal study to provide evidence that FFA4 may mediate the protective roles of n-3 fatty acids on lean mass percentage as well as fat mass percentage. PMID: 28900676
4. Data suggest that omega-3 fatty acids, common dietary lipids, participate in immunomodulation; here, EPA (eicosapentaenoic acid) activates macrophage RAW264.7 cells through GPR120-mediated Raf-ERK1/2-IKKbeta-NFkappaB p65 signaling pathways. PMID: 28841192
5. GPR120 suppresses adipose tissue lipolysis and synergizes with GPR40 in antidiabetic efficacy PMID: 28583918
6. Docosahexaenoic acid activates GPR120 to prevent experimental colitis in IL-10 deficient mice. PMID: 28039475
7. GPR120 (and GPR40) act in concert in the hypothalamus to reduce energy efficiency and regulate the inflammation associated with obesity. PMID: 28446241
8. Acute reductions in food intake and food reward suggest that GPR120 could mediate the effects of central omega-3 polyunsaturated fatty acids to inhibit appetite. PMID: 26888796
9. These data reveal important structure-function and signaling differences between the two FFA4 isoforms, and for the first time link FFA4 to modulation of ROS in macrophages. PMID: 28943238
10. Results provide evidence that GPR120 promotes adipogenesis by increasing PPARgamma expression via [Ca(2+)]i and ERK1/2 signal pathway in 3T3-L1 adipocytes. PMID: 27302893
11. GPR120-induced incretin glucse-dependent insulinotropic polypeptide secretion is indirectly mediated by cholecystokinin. PMID: 28324023
12. Leukocyte GPR120/FFAR4 WT or KO mice in the LDL receptor KO background were generated by bone marrow transplantation.leukocyte GPR120 expression has minimal effects on dietary PUFA-induced plasma lipid/lipoprotein reduction and atheroprotection, and there is no distinction between n-3 versus n-6 PUFAs in activating anti-inflammatory effects of leukocyte GPR120/FFAR4 in vivo PMID: 27811230
13. Collectively, these findings showed that SA suppressed mammary gland development of pubertal mice, which was coincident with the SA-inhibited HC11 proliferation, and was associated with inhibition of PI3K/Akt signaling pathway through activation of GPR120. PMID: 28712865
14. omega-3 fatty acids-induced proliferation of bronchiole epithelial cells through FFA4 is responsible for Omacor-induced accelerated recovery from airway injury. PMID: 28314803
15. GPR120 silencing in adipocytes inhibited the expression of PPARgamma and miR-143, whereas GPR120 overexpression led to increased expressions of PPARgamma and miR-143. PMID: 28495174
16. GPR120 expression in beta-cells and GPR120-mediated insulinotropic effects are altered in obesity and diabetic states in distinct ways, and these alterations may be mediated by PPARgamma. PMID: 27980130
17. Data show that agonizing G protein-coupled receptor 120 (GPR120) differentially regulates the pro-inflammatory adipocytokines. PMID: 28263744
18. FFA4 is a dual-acting factor that increases osteoblastic bone formation and decreases osteoclastic bone resorption PMID: 27145004
19. work identifies a novel function of Ffar4 in modulating brown adipogenesis partly through a mechanism involving cAMP activation and up-regulation of miR-30b and miR-378. PMID: 27489163
20. GPR120 is a negative modulator of osteoclast development. PMID: 26280807
21. demonstrated a GPR120-mediated novel anti-inflammatory pathway in specific intestinal epithelial cell types that could be of therapeutic relevance to intestinal inflammatory disorders PMID: 26791484
22. Data suggest phosphorylation of Ffar4 occurs at 3 serine and 2 threonine residues clustered in 2 separable regions of C-terminal tail; recruitment of arrestin 3, receptor internalization, and activation of Akt are regulated by Ffar4 phosphorylation. PMID: 26873857
23. GPR120-mediated cellular signalling determines the bi-potential differentiation of BMMSCs in a dose-dependent manner. PMID: 26365922
24. GPR 40/120 double-knockout mice are impaired in post-oral fat sensing. PMID: 25911263
25. co-transfection of GPR120 enhanced eicosapentaenoic acid-induced PPARgamma binding to PPAR-response element in VEGF-A promoter region. PMID: 25697344
26. results indicated that the beneficial metabolic role of DHA was attributed to its ability to regulate glucose via the GPR120-mediated AMPK pathway in the skeletal muscles PMID: 26134561
27. The GPR120 in mouse pituitary gonadotropes is upregulated by fasting and that it may play a role in controlling gonadotropin secretion. PMID: 25112963
28. Results suggest that GPR120 is not indispensable for the improved metabolic profile associated with intake of a diet enriched in n-3 polyunsaturated fatty acids. PMID: 25541716
29. GPR120 is expressed abundantly in K cells of the upper small intestine and plays a critical role in lipid-induced GIP secretion. PMID: 25535828
30. The results imply that GPR120 is selectively present within the delta cells of murine islets and that it regulates somatostatin secretion. PMID: 24663807
31. GPR120 is a nutrient sensor that is activated endogenously by both saturated and unsaturated long chain fatty acids. PMID: 24742677
32. CD36 and GPR120 have nonoverlapping roles in taste bud cell signaling during orogustatory perception of dietary lipids; these are differentially regulated by obesity. PMID: 24412488
33. GPR40 and GPR120, two fatty acid responsive G-protein-coupled receptors (GPCRs), are expressed in taste bud cells, and knockout mice lacking either of those receptors have blunted taste nerve responses PMID: 23831422
34. results suggest that the decrease of ghrelin secretion after feeding is induced partially by long-chain fatty acids that act directly on gastric G-protein coupled receptor 120(GPR120)-expressing ghrelin cells PMID: 24222669
35. GPR40 and GPR120 fatty acid sensors are critical for postoral but not oral mediation of fat preferences in the mouse. PMID: 24154510
36. GPR120-deficient mice fed a high-fat diet develop obesity, glucose intolerance and fatty liver with decreased adipocyte differentiation and lipogenesis and enhanced hepatic lipogenesis PMID: 22343897
37. In contrast to GPR120, CD36 appears to be a food-sensitive lipid sensor in the gustatory circumvallate papillae PMID: 21901153
38. GPR120 is a functional omega-3 fatty acid receptor/sensor and mediates potent insulin sensitizing and antidiabetic effects in vivo by repressing macrophage-induced tissue inflammation. PMID: 20813258
39. GPR120 is expressed in the taste buds, mainly in type ii cells. GPR120 knockout mice show a diminished preference for linoleic acid and oleic acid. PMID: 20573884
40. Regulates adipogenic processes such as adipocyte development and differentiation. PMID: 17250804
41. long-chain free fatty acids induce cholecystokinin secretion through GPR120-coupled Ca2+ signaling. PMID: 17972064
42. GPR120 is mainly expressed in the type II taste cells and might function as a sensor for dietary fat. PMID: 19071193
43. Immunoreactivity for GPR120 was abundant in the mouse large intestine, lung, and adipose tissue. Expression of GPR120 protein was up-regulated during the adipogenic differentiation of 3T3-L1 cells. PMID: 19145429

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KEGG: mmu:107221

STRING: 10090.ENSMUSP00000063660

UniGene: Mm.35288