Recombinant Mouse Peroxisome proliferator-activated receptor alpha(Ppara)

1. For the first time, we report here the importance of GPER-PPARalpha and -PPARgamma 'neopartnership' in maintenance of Leydig cell morpho-functional status. PMID: 30149370
2. Integrated transcriptomics and proteomics data predicted the activation of TGF beta and inactivation of PPAR alpha signaling pathways in mouse heart tissue 40 weeks after local radiation exposure (16 Gy). This study strongly suggests a crosstalk between the two pathways via MAPK signaling. PMID: 27805817
3. The study suggests that persistent alteration of cardiac metabolism due to impaired PPAR alpha activity contributes to the heart pathology after radiation.Ionizing radiation markedly changed the phosphorylation and ubiquitination status of PPAR alpha. This was reflected as decreased expression of its target genes involved in energy metabolism and mitochondrial respiratory chain. PMID: 23560462
4. These results indicate that wistin could suppress lipid accumulation through PPARalpha activation. The action of wistin on PPARalpha could be of interest for the amelioration of lipid metabolic disorders. PMID: 29318455
5. These data may indicate that insulin resistance in Adp(-/-) mice is likely caused by an increase in concentrations of TNFalpha and FFA via downregulation of PPARalpha. PMID: 29445073
6. Results from transcriptional and epigenomic analyses in the livers of mice fed either a high-fat diet or nutrition-restricted diet, found extensive binding of PPARalpha near genes involved in glycolysis/gluconeogenesis and uncovered a role for this factor in regulating anaerobic glycolysis. PMID: 28282965
7. Peroxisome proliferator-activated receptor alpha (PPARalpha) target gene expression was almost absent in contrast to increased lipid synthesis in the TIS21 protein (TIS21) knockout (TIS21-KO) mice compared to WT mice. PMID: 29385670
8. Clofibrate treatment revealed an essential role of PPARalpha in regulating hepatic bile acid synthesis, transport and signaling. PMID: 28973556
9. The authors identify an endogenous role for PPARalpha in retinal neuronal survival and lipid metabolism, and furthermore underscore the importance of fatty acid oxidation in photoreceptor survival. They also suggest PPARalpha as a putative therapeutic target for age-related macular degeneration, which may be due in part to decreased mitochondrial efficiency and subsequent energetic deficits PMID: 29183319
10. p21 plays a relevant role in fasting adaptation through the positive regulation of PPARalpha. PMID: 27721423
11. PPARalpha is required for the ChREBP-induced glucose response of FGF21. Loss of PPARalpha impairs Fgf21 promoter accessibility at the carbohydrate-responsive element . PMID: 29020627
12. Data, including data from studies in knockout mice, suggest that hepatic induction of cytochrome P450s (Cyp3a, Cyp2b, and Cyp2c) by hypolipidemic agent gemfibrozil is suppressed by Ppara activation. PMID: 28374976
13. We demonstrated that PPARalpha activation contributes to liver protection and decreases liver inflammation in acute liver failue (ALF), particularly through regulating CHOP. Our findings may provide a rationale for targeting PPARalpha as a potential therapeutic strategy to ameliorate ALF. PMID: 28600667
14. These findings indicate that PPARalpha promotes osteogenic differentiation via the Sirt1-dependent signaling pathway. PMID: 28614912
15. CD36 is essential for endurance improvement, changes in whole-body metabolism, and efficient peroxisome-proliferator activated receptors (PPAR)-related transcriptional responses in the muscle with exercise training. PMID: 28526781
16. In mice, the oral administration of linalool for 3 weeks reduced plasma TG concentrations in Western-diet-fed C57BL/6J mice (31%, P < 0.05) and human apo E2 mice (50%, P < 0.05) and regulated hepatic PPARalpha target genes. PMID: 24752549
17. a novel PPARalpha-dependent gene PMID: 28442498
18. fenofibrate upregulated VLDLR transcriptional activity through PPAR response element binding to the VLDLR promoter. PMID: 24899625
19. PPARalpha activation contributes to liver protection and decreases hepatocyte apoptosis in acute liver failure, particularly through regulating endoplasmic reticulum stress. PMID: 27482818
20. These results suggest that HCVcp-induced age-dependent PPARalpha activation increases synthesis of sulfatides and the resulting sulfatide accumulation affects HCV-related liver cancer. PMID: 27318478
21. These findings suggested that PPARalpha activation in adipose tissue contributes to the improvement of glucose metabolism disorders via the enhancement of BCAA and FFA metabolism. PMID: 28919422
22. Hepatic PARP1 activation inhibits FAO pathway upregulation through poly(ADP-ribosyl)ation of PPARalpha, worsening hepatic steatosis and inflammatory responses associated with overnutrition. PMID: 27979751
23. TGF-beta and PPARalpha signaling pathways are involved in radiation-induced heart fibrosis, metabolic dysregulation, and impaired heart contractility, a pathophysiological condition that is often observed in patients that received high radiation doses in thorax. PMID: 27805817
24. This study identifies an endocrine developmental axis in which fetal GR primes the activity of PPARalpha in anticipation of the sudden shifts in postnatal nutrient source and metabolic demands. PMID: 27367842
25. findings identify a new important innate immune function for the PPARalpha signaling pathway in regulating intestinal inflammation, mucosal immunity, and commensal homeostasis PMID: 27183583
26. our data indicate that PPAR-alpha mediates antimicrobial responses to mycobacterial infection by inducing TFEB and lipid catabolism. PMID: 28275133
27. adiponectin inhibited endoplasmic reticulum stress and apoptosis of adipocyte in vivo and in vitro by activating the AMPK/PPARalpha/ATF2 pathway. PMID: 27882945
28. It was concluded that decreased cardiac PPARalpha expression is essential for adaptive metabolic remodeling in hypoxia, but is prevented by dietary fat. PMID: 27103577
29. these results indicate that PPAR-a accelerates important pathways for the clearance of a-ClFA, and a-ClFA may, in part, accelerate its catabolism by serving as a ligand for PPAR-a PMID: 28007964
30. PPARgamma controls the cancer stem cell niche PMID: 26686086
31. In mice fed with a high-fat diet, palmitoleic acid supplementation stimulated the uptake of glucose in liver through activation of AMPK and FGF-21, and was dependent on PPARalpha. PMID: 27925195
32. Myocardial PPARalpha is down-regulated in animals fed a high-fat diet. PMID: 27253588
33. FGF21 is not critical for bone homeostasis or actions of PPARalpha and PPARgamma. PMID: 27505721
34. Perfluoroalkyl acids addition to activating PPARalpha as a primary target, also have the potential to activate CAR, PPARgamma, and ERalpha as well as suppress STAT5B. PMID: 28558994
35. PPARalpha and its target gene expression were significantly increased only in the kidneys of Irbe-treated WT mice. PMID: 27496805
36. PPAR-alpha activation during pressure-overloaded heart failure improved myocardial function and energetics. PMID: 28011586
37. These studies conclusively show that cell proliferation is mediated exclusively by PPARA activation in hepatocytes and that Kupffer cell PPARA has an important role in mediating the anti-inflammatory effects of PPARA agonists. PMID: 28082284
38. PPARalpha expression supports the hyperdynamic cardiac response early in the course of sepsis and that increased fatty acid oxidation may prevent morbidity and mortality. PMID: 27881386
39. the metabolic events, controlled by PPARs, occurring during neuronal precursor differentiation, the glucose and lipid metabolism was investigated. PMID: 27860527
40. Phospho-AMPK is a molecular switch able to cooperate with glucocorticoid receptors and Ppar-alpha at the chromatin level, a novel adaptation mechanism to prolonged fasting. PMID: 27576532
41. These data raise the possibility that ATGL deficiency could impair the renal fatty acid metabolism though inhibiting PPARalphaexpression, which may lead to lipid deposition and cell apoptosis of PCT, and finally contribute to the renal fibrosis and dysfunction PMID: 28400046
42. GRbeta antagonizes the GC-induced signaling during fasting via GRalpha and the PPARalpha-FGF21 axis that reduces fat burning. Furthermore, hepatic GRbeta increases inflammation, which leads to hepatic lipid accumulation. PMID: 27784782
43. These findings reveal a novel BVRA-GSKbeta-PPARalpha axis that regulates hepatic lipid metabolism and may provide unique targets for the treatment of non-alcoholic fatty liver disease. PMID: 27738106
44. CYP2A5 protects against the development of alcoholic fatty liver disease, and the PPARalpha-FGF21 axis contributes to the protective effects of CYP2A5 on alcoholic fatty liver disease. PMID: 28131861
45. Cyp1b1 affects external control of mouse hepatocytes, fatty acid homeostasis and signaling involving HNF4alpha and PPARalpha. PMID: 27036855
46. Chronic stimulation of PPARalpha may suppress the autophagy capacity in the liver as a result of reduced content of a number of autophagy-associated proteins independent of FGF21. PMID: 28422956
47. The results indicate that alterations in PGC-1a acetylation and expression level might contribute to the regulation of melanogenesis by PPARalpha and fenofibrate. PMID: 28084540
48. Inhibition of adipose tissue PPARgamma prevented LipX-induced increases in adipocyte expansion and produced a glucose-intolerant phenotype PMID: 27976431
49. Data, including data from knockout mice, suggest critical role for PPARalpha in endocrine disruptor-/herbicide-/2,4-dichlorophenoxyacetic acid-induced male infertility due to disruption of spermatogenesis and cholesterol/testosterone homeostasis in Leydig cells of testis. PMID: 26838045
50. Inhibition of PPAR-alpha is associated with protection against doxorubicin-induced cardiotoxicity in mice, and cannabinoids can potentiate the protection by PPAR-alpha blockade. PMID: 26082188

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KEGG: mmu:19013

STRING: 10090.ENSMUSP00000059719

UniGene: Mm.212789