Recombinant Mouse Probable ATP-dependent RNA helicase DDX58 (Ddx58), partial

1. FBXW7 is critical for RIG-I stabilization during antiviral responses. PMID: 28287082
2. Identification of a second binding site on the RIG-I TRIM25 B30.2 domain has been reported. PMID: 29259080
3. Elevated retinoic acid-inducible gene 1 (RIG-I) modulated the interaction of activated proto-oncogene c-Src (Src) and STAT3 by competitive binding to STAT3. PMID: 27349479
4. innate immune signaling mediated by RLR plays a critical role in nuclear reprogramming. PMID: 28276156
5. Toll-like receptor 2 (TLR2) and retinoic acid-inducible gene I (RIG-I) cooperatively initiate innate immune responses to MuV infection in mouse ovarian granulosa cells. PMID: 27477784
6. Collectively, these results uncover an independent functional contribution of the apo-Rig-I/Stat3 interaction in the maintenance of Treg/Th17 cell balance. PMID: 28550197
7. The RIG-I, as well as the adaptor protein mitochondrial antiviral signaling protein, regulates NF-kappaB-mediated induction of adhesion molecules and proinflammatory cytokine expression in response to LPS. PMID: 27183587
8. RIG-I subsequently localized to antiviral stress granules induced after viral replication complexes formation PMID: 26862753
9. identifies DDX58 and MTHFSD as two TDP-43 targets that are misregulated in amyotrophic lateral sclerosis. 1 PMID: 26525917
10. Cytosolic LMW FGF2 functions as a negative regulator in RIG-I-mediated antiviral signaling. PMID: 26466960
11. findings suggest that RIG-I directs a typical IFN-dependent antiviral response against an RNA virus capable of suppressing the RNAi response PMID: 25843799
12. The results describe a novel, interactive relationship between RIG-I downstream signalling molecules resulting in efficient anti-viral immunity. PMID: 25158146
13. senses hepatitis B virus RNA, and counteracts HBV polymerase PMID: 25557055
14. RIG-I-like receptor (RLR) signaling pathway was significantly affected by Yersinia pestis infection PMID: 25064677
15. the suppression of RIG-I induction and antiviral cytokine responses by Cigarette smoke are likely important in the enhanced susceptibility of smokers to influenza infection in the lung. PMID: 25260755
16. the minimal determinant for RIG-I recognition is a base-paired RNA with 5'pp; such RNAs are found in some viruses but not in uninfected cells, so recognition of 5'pp-RNA acts as a powerful means of self/non-self discrimination by the innate immune system PMID: 25119032
17. Adenosine deaminase acting on RNA 1 limits RIG-I RNA detection and suppresses IFN production responding to viral and endogenous RNAs. PMID: 25172485
18. Smurf2 negatively modulates RIG-I-dependent antiviral response by targeting VISA/MAVS for ubiquitination and degradation. PMID: 24729608
19. Overexpression of USP21 inhibited RNA virus-induced RIG-I polyubiquitination and RIG-I-mediated interferon signaling, while USP21 deletion resulted in elevated RIG-I polyubiquitination, IRF3 phosphorylation, IFN production, and antiviral responses. PMID: 24493797
20. The current study demonstrates that melanoma differentiation-associated protein 5 (MDA5) and retinoic acid-inducible gene I (RIG-I) initiate the testicular innate antiviral response. PMID: 23820901
21. Data show that the activation of the microtubule-associated guanine nucleotide exchange factor GEF-H1, encoded by Arhgef2, is essential for sensing of foreign RNA by RIG-I-like receptors. PMID: 24270516
22. Although ZAP was known as a regulator of RIG-I signaling in a human cell line, ZAP deficiency does not affect the RIG-I-dependent production of type I IFN in mouse cells PMID: 23836649
23. these findings suggest that mast cells produce cytokines and chemokines in the early infection stage after recognizing viruses via RIG-I and MDA5, and may contribute to antiviral responses. PMID: 23171655
24. combining TGF-beta gene silencing with RIG-I signaling confers potent antitumor efficacy against pancreatic cancer by breaking tumor-induced CD8(+) T cell suppression PMID: 23338611
25. Rift Valley fever virus-induced activation of IFN-beta is dependent on RIG-I. PMID: 23408632
26. Rig-I regulates NF-kappaB activity through binding to Nf-kappab1 3'-UTR mRNA. PMID: 23553835
27. influenza NS1 protein targets TRIM25 and Riplet ubiquitin E3 ligases in a species-specific manner for the inhibition of RIG-I ubiquitination and antiviral IFN production. PMID: 23209422
28. Data reveal a negative feedback loop of RIG-I signaling and identify a Siglec-G-mediated immune evasion pathway exploited by RNA viruses. PMID: 23374343
29. The finding that RIG-I responds to S. flexneri infection during the IFNgamma response extends the range of PRRs that are capable of recognizing this bacterium. PMID: 22912573
30. HCV PAMP motif drives potent RIG-I signaling to induce the innate immune response to infection. PMID: 22912574
31. analysis of inhibition of influenza A virus infection by gene silencing through 5'-Triphosphate-short interfering RNA and RIG-I activation PMID: 22787226
32. This study shows that activation of the cytoplasmatic nucleic acid receptor RIG-I leads to endothelial dysfunction. RIG-I induced endothelial damage could therefore be an important pathway in atherogenesis. PMID: 22402283
33. RIG-I as an innate immune sensor of cytosolic HIV genomic RNA with secondary structure PMID: 22235281
34. The activation of RIG-I occurs through an RNA- and ATP-driven structural switch in the SF2 domain. PMID: 21979817
35. Arterivirus and nairovirus deubiquitinases target RIG-I to control innate immune signaling. PMID: 22072774
36. The inhibitory effects of poly(I:C) are mediated by retinoic acid-inducible gene (RIG)-like helicase (RLH) PMID: 21278304
37. Klotho suppresses RIG-I-mediated senescence-associated inflammation PMID: 21336305
38. Among the rabies virus N protein mutants those with mutations at positions 273 and 394 evaded activation of RIG-I-mediated signaling most efficiently and also showed the highest pathogenicity. PMID: 20875468
39. RIG-1 - MAVS interacts with cytoplasmic 100-kDa NF-kappa B2 complexes via a novel retinoic acid-inducible gene-I - NF- kappa B-inducing kinase signaling pathway [RIG-1 (RARRES3, TIG3)] PMID: 18550535
40. Rig-I has a critical regulatory role in modulating the generation and differentiation of granulocytes [RIG-I, also callede RARRES3 or TIG3] PMID: 18650396
41. Phosphorylation-mediated negative regulation of RIG-I antiviral activity. PMID: 20071582
42. Results identify the CARD9-Bcl-10 module as an essential component of the RIG-I dependent proinflammatory signaling for interleukin 1 beta production in response to certain RNA viruses. PMID: 19915568
43. RIG-I is essential for induction of type I interferons (IFNs) after infection with RNA viruses in fibroblasts and conventional dendritic cells (DCs). PMID: 16039576
44. A disparate regulatory role for DExD/H box RNA helicase LGP2 in the triggering of innate immune signaling pathways following RNA virus infection. PMID: 17475874
45. Findings suggest that Rig-I has crucial roles in the regulation of G alpha i2 expression and T-cell activation, and the development of colitis may be associated with downregulation of G alpha i2 and disturbed T-cell homeostasis. PMID: 17893708
46. RIG-I plays a key role in the regulation of tumor necrosis factor (TNF)-alpha expression via Toll-like receptor-4 signaling pathway in macrophages in response to lipopolysaccharide stimulation. PMID: 18523264
47. results provide a conceptual advance by defining specific homopolymeric RNA motifs within the genome of HCV and other RNA viruses as the PAMP (pathogen-associated molecular patterns) substrate of RIG-I PMID: 18548002
48. It is a molecule that senses viral RNA in cytoplasms and plays a roll in the signal transduction and innate immunity. (review) PMID: 18975620
49. RIG-I interacts with poly-I/C in vivo, and that heteropolymeric dsRNA and poly-I/C interact directly with RIG-I in vitro, but in different ways. PMID: 19115016
50. Data show that activation of p38 MAPK by RIG-I proceeds via a TRAF2-TAK1-dependent pathway, where the enzymatic activity of the kinase plays an essential role. PMID: 19224920

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KEGG: mmu:230073

STRING: 10090.ENSMUSP00000042433

UniGene: Mm.86382