Recombinant Mouse Protein arginine N-methyltransferase 1 (Prmt1)

1. PRMT activity is selectively augmented during the initial activation of exercise-induced skeletal muscle remodeling in vivo. PMID: 29112628
2. the present study increases our understanding of PRMT1, -4, and -5 biology during the plasticity of skeletal muscle development. Our results provide evidence for a role of PRMT1, via a mitochondrially mediated mechanism, in driving the muscle differentiation program. PMID: 29208765
3. lipotoxicity-induced PRMT1 expression promotes endoplasmic reticulum stress-mediated mesangial cell apoptosis. PMID: 28671608
4. PRMT1 is an arginine methyltransferase involved in a variety of cell functions. Here the authors delete PRMT1 specifically in mature B cells to show the importance of arginine methylation for B cell proliferation, differentiation and survival, and thereby for humoral immunity. PMID: 29026071
5. Collectively, this study firstly demonstrated that PRMT1 exert podocyte-injury effects in mouse glomerulus through Ang /ERK pathway, which reveals a potential therapeutic target for DN. PMID: 29129692
6. Low Prmt1 expression is associated with osteosarcoma. PMID: 28655788
7. Collectively, the authors propose that Prmt1-dependent facilitation of KCNQ-phosphatidylinositol-4,5-bisphosphate interaction underlies the positive regulation of KCNQ activity by arginine methylation, which may serve as a key target for prevention of neuronal hyperexcitability and seizures. PMID: 27466704
8. Data, including data from studies in cells from knockout mice, suggest that Prmt1 activity was necessary for c-Myc binding to acetyltransferase p300 in myeloid cells; Prmt1 inhibition decreases p300 recruitment to c-Myc target promoters and increased Hdac1 recruitment. [Prmt1, protein arginine N-methyltransferase 1; c-Myc = Proto-Oncogene Proteins c-myc; Hdac1 = histone deacetylase 1] PMID: 28652407
9. PRMT1-dependent regulation of macrophage PPARgamma expression contributes to the infection susceptibility in PRMT1 knock-out mice PMID: 28330868
10. These findings suggest that arginine methylation by PRMT1 regulates muscle stem cell fate through the Eya1/Six1/MyoD axis. PMID: 27849571
11. PRMT1 is necessary for lymphocyte functions in vivo. PMID: 27013173
12. The Protein arginine methyltransferase 1 (PRMT1) is involved in multiple cellular functions including proliferation and differentiation and PRMT1 is important for embryonic vascular formation. PMID: 28003433
13. PRMT1 is required for CNS development, especially for oligodendrocyte maturation processes PMID: 26637354
14. Pharmacological inhibition of KDM4C/PRMT1 suppresses transcription and transformation ability of MLL fusions PMID: 26766589
15. PRMT1 knockdown reduced H4R3me2a expression to alter potential H3K9/K14 acetylation by acetyltransferases, and to eventually result in diminished acH3K9/K14 modification in nucleus accumbens. PRMT1 is the main enzyme responsible for this modification. PMID: 26377474
16. Study provides evidence for loss of PRMT1 function as a consequence of cytoplasmic accumulation of FUS in the pathogenesis of amyotrophic lateral sclerosis, including changes in the histone code regulating gene transcription. PMID: 25274782
17. In vivo, levels of lipogenic proteins, inflammatory molecules, PGC-1alpha, and PRMT1 were increased in the livers of HFD mice compared with those fed a chow diet, and were ameliorated in HFD Txnip(-/-) mice. PMID: 25003952
18. GSK3- and PRMT-1-dependent modifications of desmoplakin control desmoplakin-cytoskeleton dynamics. PMID: 25733715
19. PRMT1 concentrates in cytoplasmic bodies, which respond to DNA injury in the cell nucleus PMID: 24998928
20. PRMT1-mediated arginine methylation could be implicated in the nucleus-cytoplasmic shuttling of FUS/TLS. PMID: 23152885
21. PRMT1-dependent regulation of FoxO1 is critical in hepatic glucose metabolism in vivo. PMID: 22532369
22. Depletion of PRMT1 diminished the ability of ALS-linked FUS mutants to localize to the cytoplasm. PMID: 21965298
23. PRMT1-mediated dimethyl H4R3 facilitates histone acetylation and enhancer/promoter communications, which lead to the efficient recruitment of transcription preinitiation complexes to active promoters. PMID: 20068219
24. Type I protein arginine methyltransferase (PRMT) activity produces asymmetric dimethylation of the terminal guanidinonitrogen of arginines in substrate proteins, particularly glycine and arginine-rich (GAR) segments of proteins PMID: 11835310
25. Prmt1 has a role in hnRNP assembly PMID: 12397599
26. These results demonstrate that PRMTs are expressed and functional in the lung, and that hypoxia is a potent regulator of PRMT2 expression and lung ADMA concentrations. These PMID: 16690984
27. C-terminal domain containing the methylated arginine residues is known to promote PAPBN1 self-association, and arginine methylation has been reported to inhibit self-association of an orthologous protein PMID: 18495660
28. demonstrated mutual interactions and functional interplays between PXR and PRMT1, and this interaction may be important for the epigenetics of PXR-regulated gene expression PMID: 19144646
29. Arginine methylation by PRMT1 is a key posttranslational modification in the DNA damage response pathway in proliferating mammalian cells. PMID: 19289494

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KEGG: mmu:15469

STRING: 10090.ENSMUSP00000103474

UniGene: Mm.27545