Recombinant Mouse Receptor tyrosine-protein kinase erbB-4(Erbb4),partial

Code CSB-YP713977MO
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Source Yeast
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Code CSB-EP713977MO
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Source E.coli
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Code CSB-EP713977MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP713977MO
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Source Baculovirus
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Code CSB-MP713977MO
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Source Mammalian cell
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Product Details

>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
Erbb4; Mer4Receptor tyrosine-protein kinase erbB-4; EC; Proto-oncogene-like protein c-ErbB-4) [Cleaved into: ERBB4 intracellular domain; 4ICD; E4ICD; s80HER4)]
Mus musculus (Mouse)
Protein Length
Tag Info
The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Target Background

Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis.
Gene References into Functions
  1. Data suggest no direct involvement of a classical Nrg-ErbB4 pathway in attention and inhibitory control in mice, while it confirms the involvement of this pathway in other domains relevant to schizophrenia. PMID: 28792672
  2. Erbb4-IR is a Smad3-dependent lncRNA that promotes renal fibrosis in type 2 diabetic nephropathy by suppressing miR-29b. PMID: 29222368
  3. Deleting ErbB4 in parvalbumin-expressing neurons (PV neurons) significantly attenuated oligomeric Abeta-induced suppression of long term potentiation (LTP). Furthermore, specific ablation of ErbB4 in PV neurons via Cre/loxP system greatly improved spatial memory and synaptic plasticity in the hippocampus of human APP-J20 mice. PMID: 28684271
  4. Study found that the ErbB4 signaling pathway in the prelimbic cortex was necessary to modulate fear expression. PMID: 28675393
  5. Receptor protein-tyrosine kinase ErbB-4 (ERBB4) is expressed in the basal layer of human epidermis and cultured keratinocytes as well as in murine epidermis. PMID: 29410073
  6. The manipulation of NRG1/ErbB4 signaling in the present study revealed that NRG1/ErbB4 activity in the hippocampus is critical for learning and memory. PMID: 27295274
  7. This study demonstrated that deletion of the endothelial ErbB4 receptor is associated with reduced glucose transport ability and is a key element involved in energy metabolism for brain function. PMID: 28421673
  8. we show that the antifibrotic effect of neuregulin-1 is at least partially mediated through anti-inflammatory activity, linked to receptor tyrosine-protein kinase erbB-4 activation in macrophages PMID: 28822966
  9. These results suggest that the neuropsin-NRG1 signaling system has a role in pathological processes underlying temporal lobe epilepsy by regulating the activity of parvalbumin-expressing interneurons, and that neuropsin regulates E/I balance and gamma oscillations through NRG1-ErbB4 signaling toward parvalbumin-expressing interneurons. PMID: 28267150
  10. findings reveal molecular, cellular, and circuit mechanisms of NRG1/ErbB4 in regulating the initiation of critical period visual cortical plasticity. PMID: 27641496
  11. To our knowledge, this is the first evidence that ErbB4 signaling in the MSNs is involved in the pathology of schizophrenia. PMID: 28667174
  12. Study revealed that bed nucleus of the stria terminalis NRG1-ErbB4 signaling is involved in regulating anxiety, and that blocking this pathway produced anxiety-like behavior. PMID: 27189883
  13. Parallel microarray profiling identifies Erbb4 as a marker of cyst growth in autosomal dominant polycystic kidney disease and as a prognostic marker for disease progression. PMID: 28077374
  14. a suppressor of miR-146a, suggesting an autocrine loop. Inhibition of ErbB4/EGFR with erlotinib co-treatment of podocytes suppressed this signaling. Findings suggest a novel role for miR-146a in protecting against diabetic glomerulopathy and podocyte injury. PMID: 27913625
  15. the disruption of NRG1-ErbB4 signaling in the parvalbumin interneurons mediated by neuroinflammation might lead to abnormal gamma oscillations and thus contribute to cognitive impairment in a mouse model of SAE PMID: 27913953
  16. the cleavage of ErbB4 by calpain contributes to a neuronal cell death cascade during brain ischemia. PMID: 26093380
  17. Elevated coexpression of KITENIN and ErbB4-CYT-2 promotes the transition of colon adenoma to adenocarcinoma within an APC loss-associated tumor microenvironment PMID: 26527747
  18. A combination of miRNAs induced via endothelial coculture improved embryonic-stem-cell-derived cardiomyocytes maturity, in part through suppression of ErbB4 signaling. PMID: 26365191
  19. These results suggest a mechanism by which cross-talk between DISC1 and NRG1-ErbB4 signalling may contribute to these deficits. PMID: 26656849
  20. Findings reveal an intimate reciprocal relationship between ErbB4 and GluN2b NMDA receptors via NRG2/ErbB4 signaling. PMID: 26027736
  21. ERBB4 overexpression potentiates Mesenchymal stem cell survival in the infarcted heart, enhances NRG1 generation to restore the declining NRG1 in the infarcted region and stimulates cardiomyocyte division. PMID: 25996292
  22. The observations of this study indicated that NRG1-ErbB4 signaling is critical to maintaining GABAergic activity in the amygdala and thus to modulating anxiety-like behaviors. PMID: 25308353
  23. Although ERBB4 is dispensable for naive ERBB2+ breast cancer cells, it may play a key role in the survival of ERBB2+ cancer cells after they develop resistance to ERBB2 inhibitors, lapatinib and trastuzumab. PMID: 25590338
  24. In the current study, we demonstrated that ErbB4 deletion in cpk mice, a murine autosomal recessive polycystic kidney disease model, promoted cyst formation and accelerated renal function decline. PMID: 24670412
  25. the ErbB4 receptor tyrosine kinase promotes seminiferous tubule development by controlling Sertoli cell and germ cell adhesion PMID: 25058600
  26. TrkB mutants showed that intercellular domain of TrkB is necessary for TrkB-ErbB4 interaction and NR2B activation. PMID: 25052836
  27. The results of this study suggested that ErbB4 signaling in excitatory pyramidal cells is critical for the proper formation and maintenance of dendritic spines in excitatory pyramidal cells. PMID: 24752666
  28. We propose that ErbB4 sets the sensitivity of the thalamic reticular nucleus to cortical inputs at levels that can support sensory selection while allowing behavioral flexibility PMID: 25501036
  29. Expression of ErbB4 was reduced in the lobulalveoli with mammary gland-specific deletion of Hif1a. Erbb4 was not, however, a direct target gene for transcriptional regulation by HIF-1alpha in vitro. PMID: 24966332
  30. Specific ablation of ErbB4 in PV+ neurons reduced eIPSC/eEPSC ratios and impaired fear conditioning. Notably, expression of ErbB4 in amygdala was sufficient to diminish synaptic dysfunction and fear conditioning deficits in PV-ErbB4-/- mice PMID: 25451196
  31. Findings suggest that NRG1/ErbB4 signaling plays an important role in the synchronized oscillations of the whole network in the prefrontal cortex PMID: 24374327
  32. Data show that each of the four ErbB4 isoforms is able to confer cells with an adhesion preference for cells expressing the transmembrane neuregulin 1 type III PMID: 24518229
  33. PSEN-1 cleavage of ErbB4 for non-canonical signaling through 4ICD release does not require prior cleavage by TACE PMID: 24462774
  34. ErbB4 signals contribute to the development of GABAergic circuitry associated with fast-spinking basket cells in component- and stage-dependent manners in the prefrontal cortex in vivo PMID: 24336736
  35. ErbB4 is a critical upstream regulator of TTF-1 in type II epithelial cells and that this interaction is important for Sftpb regulation. PMID: 23845988
  36. Our results demonstrate a role of ErbB4 in parvalbumin-positive interneurons for spine formation in excitatory neurons PMID: 24305825
  37. This study demonistrated that loss of Erbb4 from fast-spiking interneurons also impacts many different aspects of behavior that have been associated with schizophrenia. PMID: 24050403
  38. Neuregulin1beta1 protected OPCs from OGD induced apoptosis and the possible protective mechanism is linking with ErbB4-dependent activation of PI3-kinase/Akt pathway PMID: 22659027
  39. The monosynaptic input sources that connect a subpopulation of mouse somatosensory cortex inhibitory neurons expressing ErbB4 are described. PMID: 21618237
  40. soluble ErbB4 intracellular domain promotes HIF-1alpha stability and signaling via a novel mechanism. PMID: 22308027
  41. This study demonistrated that NRG1/erbB4 promote the growth of dendrites in mature interneurons through kalirin, a major dendritic Rac1-GEF. PMID: 21483438
  42. Report down-regulation of ErbB4 expression in hypothalamic neurons induced by G-protein-coupled gonadotropin releasing hormone receptor stimulation. PMID: 21898395
  43. NRG1-induced activation of ErbB4 in parvalbumin-expressing inhibitory interneurons may serve as a critical endogenous negative-feedback mechanism to suppress limbic epileptogenesis PMID: 22158510
  44. ErbB4 signaling modulates proliferation and polarization, cellular functions critical for the development of epithelial ducts in the kidney. PMID: 22076439
  45. The ErbB4 signaling maintains high efficacy of synaptic transmission by stabilizing the postsynaptic apparatus via phosphorylation of alpha-dystrobrevin1. PMID: 22184199
  46. ErbB4 plays a major role in LPS-induced signaling in structural and functional lung development. PMID: 21724861
  47. SynCAM1 is expressed in astrocytes and contributes to erbB4 receptor-mediated control of female sexual development. PMID: 21486934
  48. ErbB4 regulates the expression of surfactant protein B in fetal lung maturation, helping to prepare for the fetal-neonatal transition. PMID: 21317380
  49. The stimulatory effects of estrogen on Sftpb are under transcriptional control of ErbB4. PMID: 21777626
  50. ErbB4-containing complexes coordinate cell growth responses to ErbB4 activation and DNA damage. PMID: 20858735

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Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Protein Families
Protein kinase superfamily, Tyr protein kinase family, EGF receptor subfamily
Tissue Specificity
Isoform JM-A CYT-2 and isoform JM-B CYT-2 are expressed in cerebellum, cerebral cortex, spinal cord, medulla oblongata and eye, but the kidney expresses solely isoform JM-A CYT-2 and the heart solely isoform JM-B CYT-2.
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