Recombinant Mouse Regulator of G-protein signaling 2 (Rgs2)

1. PKC activation appeared to increase the RGS2 translocation from nucleus to cytosol. PKA- and PKC-mediated RGS2 transcription in a Sp-1-dependent manner and a PKC-mediated RGS2 intracellular translocation were noted in granulosa cells. PMID: 29932914
2. Results confirmed the regulator of G-Protein signaling 2 (RGS2) as an interaction partner of PKGI-alpha. PMID: 29649180
3. The present results suggest that expression of the eIF2B-interacting domain of RGS2, RGS2eb, can protect against pathological cardiac hypertrophy and dysfunction in vivo. PMID: 28641980
4. RGS2 has critical roles in maintaining pancreatic beta-cell mass via modulating beta-cell function and apoptosis. PMID: 28542139
5. Results show that RGS2 negatively modulates D2R-mediated Galphai/o protein signaling in neuroblastoma N2A cells. Moreover, RGS2 critically regulates agonist-stimulated dopamine D2R internalization. RGS2 knockdown abolished quinpirole-stimulated D2R internalization and impaired beta-arrestin dissociation from the membrane. PMID: 27528587
6. Upregulated RGS2 contributes significantly to the anti-fibrotic effects of pirfenidone in idiopathic pulmonary fibrosis. PMID: 27549302
7. Modest anti-inflammatory and anti-remodelling roles for RGS2 are also suggested. If translatable to humans, therapies that maximize RGS2 expression may prove advantageous PMID: 28107494
8. RGS2 might play a critical role in mouse oocyte meiotic maturation by affecting beta-tubulin polymerization and chromosome segregation. PMID: 27463806
9. Knockdown of endogenous Rgs2 expression led to abnormal embryonic development in vitro, with a considerable number of early embryos arrested at the 2- or 4-cell stage. Moreover, mRNA expression of three zygotic gene activation-related genes (i.e. Zscan4, Tcstv1 and MuERV-L) was decreased significantly in 2-cell arrested embryos. These results suggest that Rgs2 plays a critical role in early embryo development. PMID: 24524188
10. RGS2 deficiency decreases uterine artery blood flow by increasing myogenic tone at least partly through prolonged G protein activation PMID: 26811058
11. Rgs12 has a crucial role in the function of bone-resorbing OCs, particularly in preclinical models of pathological bone loss associated with inflammation-induced bone loss and postmenopausal osteoporosis. PMID: 25909889
12. RGS2 deficiency impairs renal function and autoregulation by increasing renal vascular resistance and reducing renal blood flow. PMID: 26193676
13. FBXO44-mediated degradation of RGS2 protein uniquely depends on a Cul4B/DDB1 complex. PMID: 25970626
14. Regulator of G-protein signaling 2 (RGS2) suppresses premature calcium release in mouse eggs. PMID: 26160904
15. genetic variations and increased inflammatory cytokines can lead to RGS2 repression, which exacerbates AHR and airway remodeling in asthma. PMID: 25368964
16. RGS2 and RGS4 are new interacting partners that play key roles in G protein coupling to negatively regulate kappa-OmicronR signaling. PMID: 25289860
17. RGS2-deficient VSMC exhibit higher rates of proliferation and coordinate plasticity of Ca(2+)-handling mechanisms in response to PDGF stimulation. PMID: 24846582
18. Regulator of G protein signaling 2 deficiency accelerates the progression of kidney fibrosis PMID: 24973550
19. These findins indicate that urotensin II-induced calcium metabolism results in glomerular mesangial cell contraction and suggest that urotensin receptor activation recruts RGS2 to the plasma membrane. PMID: 24105430
20. This work provides greater insight into the stress proteome and the role of RGS2. PMID: 22922103
21. Our findings demonstrate a relationship between Rgs2 gene expression level and a propensity for anxious and depressive-like behaviour and reduced social interaction PMID: 22040681
22. RGS2 knockout caused spontaneous AHR in mice PMID: 22704538
23. Cardiomyocyte-specific RGS2 overexpression in transgenic mice in vivo did not lead to attenuate ventricular G(q/11)-mediated signaling and hypertrophy in response to pressure overload PMID: 22802950
24. systemic or endothelium-specific RGS2 deficiency causes endothelial dysfunction resulting in impaired EDHF-dependent vasodilatation. PMID: 22354966
25. RGS2 negatively regulates TLR2-mediated Nox1 expression via PKC-eta and PLD2 pathway. PMID: 22120521
26. Data show that Rgs2-deficient mice revealed enhanced bronchoconstriction to spasmogens and an absence of beta(2)-adrenoceptor agonist (LABA)-induced bronchoprotection. PMID: 22080612
27. These results indicate that Brucella abortus infection induces host RGS2 expression and that up-regulation of [Ca(2+)](i) levels is an essential factor for the intracellular survival of the bacteria within phagocytes. PMID: 22158566
28. Identification of a cAMP-response element in the regulator of G-protein signaling-2 (RGS2) promoter as a key cis-regulatory element for RGS2 PMID: 22057271
29. These findings not only define RGS2 as a novel negative regulator of the beta(2)AR-G(i) signaling but also provide a potential novel target for the treatment of chronic heart failure. PMID: 21291891
30. RGS2(-/-) pre-adipocytes had reduced levels of differentiation markers (PPAR gamma; lipoprotein lipase; CCAAT/enhancer binding protein alpha) and also rgs2(-/-) white adipocytes were small relative to controls, suggesting altered adipogenesis. PMID: 21447383
31. Rgs2 is a critical regulator of the pro-angiogenic function of myeloid derived suppressor cells in the tumor microenvironment, through regulating MCP-1 production. PMID: 21494556
32. Data show that reducing RGS2 expression by antisense treatment prevented the increase in GLO1 and GSR1 mRNA and protein expression. PMID: 21510939
33. Ischemic stress increases RGS2 expression and that this condition contributes to enhanced apoptosis in C6 cells and primary astrocytes. PMID: 20032508
34. RGS2 is an important cholinergic regulator in the atrium. RGS2(-/-) mice have enhanced susceptibility to atrial fibrillation via enhanced M3 muscarinic receptor activity. PMID: 19966055
35. Analysis of regulator of G-protein signaling-2 (RGS-2) expression and function in osteoblastic cells. PMID: 11968023
36. Parathyroid hormone induces RGS-2 expression by a cyclic adenosine 3',5'-monophosphate-mediated pathway in primary neonatal murine osteoblasts. PMID: 11996904
37. Both rgs2+/- and rgs2-/- mice exhibited a strong hypertensive phenotype, renovascular abnormalities, persistent constriction of the resistance vasculature, and prolonged response of the vasculature to vasoconstrictors in vivo. PMID: 12588882
38. Rgs2-/- mice develop marked hypertension, and their blood vessels show enhanced contraction and decreased cGMP-mediated relaxation. PMID: 14608379
39. RGS2 binds directly to the third intracellular (i3) loop of the G(q/11)-coupled M1 muscarinic cholinergic receptor (M1 mAChR; M1i3). PMID: 14976183
40. cells adapted to deletion of RGS2 by reducing Ca(2+) signaling excitability, achieved by adaptation of all transporters to reduce Ca(2+) influx into the cytosol; thus, IP(3) receptor 1 was down-regulated and IP(3) receptor 3 was up-regulated PMID: 15292238
41. Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. PMID: 15489855
42. Nitric oxide donor sodium nitroprusside can reduce blood pressure in RGS2 deficient mice. PMID: 15563583
43. Rgs2 was expressed in undifferentiated pituitary cells, was downregulated at completion of hormone cell differentiation. Pituitary cell differentiation and morphology are normal in Rgs2 mutant mice. PMID: 15661635
44. The increase in blood pressure in RGS2-/-mice is not solely explained by peripheral vascular mechanisms; a central nervous system mechanism might be implicated by an increased sympathetic tone. PMID: 15661972
45. Overexpression of Rgs2 in the chondrogenic cell line ATDC5 resulted in accelerated hypertrophic differentiation, thus providing functional validation of microarray data PMID: 16135533
46. Our data suggest an interaction between RGS2 and the NO-cGMP pathway. The blunted l-NAME response in RGS2(-/-) during the day suggests impaired NO signaling. PMID: 16269576
47. Results suggest a potential pathophysiological role of loss of fine tuning due to selective RGS2 down-regulation in G(q/11)-mediated remodeling in hypertrophic cardiomyocytes. PMID: 16380388
48. RGS2 is involved in negative feedback regulation of V2R signaling PMID: 17475820
49. We found a mismatch between sympathetic nerve traffic and plasma norepinephrine concentrations. This may depend on altered coupling between electrical nerve activity and norepinephrine release or a changed norepinephrine uptake in RGS2-/- mice. PMID: 17507294
50. group VIA phospholipase A2 (iPLA2beta) plays a pivotal role in Ang II-induced RGS2 mRNA up-regulation in vascular smooth muscle cells PMID: 17613534

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KEGG: mmu:19735

STRING: 10090.ENSMUSP00000115558

UniGene: Mm.28262