Recombinant Mouse Ryanodine receptor 1 (Ryr1), partial

1. Results suggest distinct functional roles for type 1 ryanodine receptor (RYR1) and Ca2+ channels-the 1,4-dihydropyridine receptor (Cav1.1) in skeletal primary and secondary myogenesis. PMID: 29543863
2. Results show that MG53-Orai1 interaction enhances extracellular Ca2+ entry via Orai1, and decreases intracellular Ca2+ release via RyR1 for skeletal muscle contraction. PMID: 27841305
3. Thus, RYR1 mutations may lead to prolonged bleeding by altering vascular smooth muscle cell function. The reversibility of the bleeding phenotype emphasizes the potential therapeutic value of dantrolene in the treatment of such bleeding disorders. PMID: 27382027
4. These results suggest that common molecular mechanisms underlie malignant hyperthermia (MH) crises and exertional HS in mice.- PMID: 28465322
5. This molecular rearrangement is compatible with direct inhibition of RyR opening by junctophilin-2 to intrinsically stabilise the Ca(2+) signalling properties of the junction and thus the contractile function of the cell. PMID: 27802169
6. These data demonstrate that modulating Ryrs has neuroprotective effects in nGD through mechanisms that protect the mitochondria, autophagy, Ryr expression and enhance GCase activity PMID: 27655403
7. these findings suggest an important non-contractile role of RyR1 or RYR1-mediated Ca(2+) signaling during muscle organ development. PMID: 26831464
8. mutating residue E4242 affects RyR1 structures critical for retrograde communication with CaV1.1 PMID: 26910427
9. High-intensity interval training exercise induces a ROS-dependent RyR1 fragmentation in muscles of recreationally active subjects, and the resulting changes in muscle fiber Ca(2+)-handling trigger muscular adaptations PMID: 26575622
10. The present study reveals that the C-terminal of the beta1a subunit changes conformation in the presence of RyR1 consistent with an interaction between the C-terminal of beta1a and RyR1 in resting myotubes. PMID: 26114725
11. Ryanodine receptor sensitization results in abnormal calcium signaling in airway smooth muscle cells. PMID: 25874477
12. RyR1 is required for proper release of transmitter at the neuromuscular junction, and postsynaptic RyR1 is required for the size and distribution of acetylcholine receptor clusters. PMID: 26025922
13. Spindle abnormalities precede those in extrafusal fibers, indicating that they are a primary pathological feature in this murine Ryr1-related core myopathy. [review] PMID: 25619131
14. The motif Leu(496)-Leu(500)-Trp(503) within the bet1a C-terminal tail plays a nonessential role in the bidirectional DHPR/RyR1 signaling that supports skeletal-type excitation-contraction coupling. PMID: 25384984
15. these results provide novel evidence that CaN regulates ASMC Ca(2+) sparks specifically through RyR1, which plays an important role in the control of Ca(2+) signaling and contraction in ASMCs. PMID: 25239916
16. Results suggest that RyR1 and RyR2 expressed by Purkinje and granule cells play important roles in promoting the dendritic differentiation of Purkinje cells and that RyR2 expressed by granule cells is involved in the secretion of BDNF from granule cells PMID: 24123915
17. Diminishing S-palmitoylation directly suppresses RyR1 activity as well as stimulus-coupled Ca(2+) release through RyR1. PMID: 24509862
18. CaM-binding domain of RyR2 is an important determinant of Ca2+-release termination and activation. PMID: 23992453
19. knockdown of RyR1-3 expression in wild-type hippocampal neurons to levels comparable with the RyR protein reduction in presenilin-deficient hippocampal neurons mimics the defects exhibited in calcium homeostasis and presynaptic function PMID: 23918386
20. RyR1 plays a critical role in the development of ethanol physical dependence. PMID: 23278119
21. RyR1 expression is required for Dantrolene-induced inhibition of skeletal L-type Ca2+ current PMID: 23509717
22. Nitric oxide-induced calcium release is induced by nitric oxide produced by neuronal activity through S-nitrosylation of RyR1. PMID: 23247505
23. Reduced Ca2+ release was found in muscle fibers expressing R4892W and G4896V type 1 ryanodine receptor disease mutants. PMID: 23308296
24. Suggest that the molecular mechanism underlying skeletal muscle inotropy requires enhanced sarcoplasmic reticulum Ca(2+) release due to PKA phosphorylation of S2844 in RyR1. PMID: 23070698
25. Data suggest that specific hydrophobic surface residues in calcium channel voltage-dependent beta1a subunit C-terminus bind to RyR1 and increase channel activity in lipid bilayers and thus may support skeletal muscle excitation-contraction coupling. PMID: 22962299
26. Fluorescence resonance energy transfer (FRET) indicates that association with the type I ryanodine receptor (RyR1) causes reorientation of multiple cytoplasmic domains of the dihydropyridine receptor (DHPR) alpha(1S) subunit PMID: 23071115
27. The biophysical properties, pharmacological profile, and molecular identity of store-operated Ca(2)+ entry current in skeletal myotubes, and the regulation of its rate of activation by temperature and ryanodine receptor (RyR1), was investigated. PMID: 22853897
28. Data show that mice subjected to heat stress at 37 degrees C fail to trigger malignant hyperthermia (MH) regardless of genotype of ryanodine receptor (RYR1), whereas at 41 degrees C invariably triggers fulminant MH in homozygous, but not heterozygous, mice within 20 min. PMID: 22131268
29. RyR-1 and -2 expression facilitated by D1DR stimulation are negatively regulated by GABA(B) receptor via suppression of cAMP production. PMID: 22504960
30. C2C12 cells were transfected with cDNAs encoding either wild-type RyR1. PMID: 21825032
31. Nitric oxide directly activates RyRs, which induce Ca(2+) release from intracellular stores of central neurons, & promote prolonged Ca(2+) signalling in the brain. Reversible S-nitrosylation of type 1 RyR (RyR1) triggers this Ca(2+) release. PMID: 22036948
32. Gene dose influences cellular and calcium channel dysregulation in heterozygous and homozygous T4826I-RYR1 malignant hyperthermia-susceptible muscle PMID: 22139840
33. RyR1 plays a role in voltage-induced Ca(2+) release in hypothalamic nerve terminals. PMID: 22203976
34. The expression of transgenic variants of the alpha1sDHPR leads to the replacement of native channels interacting with the ryanodine receptor 1 (RyR1), thus demonstrating the feasibility of molecular remodelling in adult skeletal muscle fibers. PMID: 21262876
35. We conclude that RyR1 exhibits differential expression and localization in two ubiquitously used mouse lines. PMID: 21933672
36. S100A1 and calmodulin bind to an overlapping domain on the ryanodine receptor type 1 to tune the Ca2+ release process, and thereby regulate skeletal muscle function. (Review) PMID: 21784520
37. leaky RyR1 contributes to age-related loss of muscle function. PMID: 21803290
38. Tric-a gene ablation inhibited RyR-mediated hyperpolarization signaling to stimulate voltage-dependent Ca(2+) influx, and adversely enhanced IP(3)R-mediated Ca(2+) transients by overloading Ca(2+) stores in VSMCs. PMID: 21803293
39. Data show that O(2)-coupled hydrogen peroxide production by Nox4 governs the redox state of regulatory RyR1 thiols and thereby governs muscle performance. PMID: 21896730
40. The conformational changes induced by DP4 regulate both orthograde excitation-contraction coupling and retrograde RyR1-DHPR signaling. PMID: 21575570
41. The RyR1-L3625D mutation removed both an early activating effect of S100A1 and calmodulin and delayed the suppression of RyR1 Ca2+ release, providing new insights into calmodulin and S100A1 regulation of skeletal muscle excitation-contraction coupling. PMID: 21289290
42. These data suggest that RyR1 is an important regulator of calcium signaling and that its physiological role in taste cells is dictated by the nature of the calcium signaling mechanisms expressed. PMID: 20955474
43. The I4895T mutation in the type 1 ryanodine receptor induces fiber-type specific alterations in skeletal muscle that mimic premature aging PMID: 20961389
44. role of mitochondria in skeletal muscle from R163C mutation in RYR1 PMID: 20978128
45. Chloroform extract of hog barn dust modulates skeletal muscle ryanodine receptor calcium-release channel (RyR1). PMID: 20576841
46. Ablation of skeletal muscle triadin impairs FKBP12/RyR1 channel interactions essential for maintaining resting cytoplasmic Ca2+. PMID: 20926377
47. Mutations in RYR1 can alter 1,4-dihydropyridine receptor activity and raise the possibility that this altered DHPR function may contribute to malignant hyperthermia episodes. PMID: 20479108
48. Conformational changes induced by the malignant hyperthermia-inducing RYR1 mutation alter signaling to the 1,4-dihydropyriding receptor, delaying the inactivation of the DHPR voltage sensor. PMID: 20479110
49. that basal sarcolemmal Ca(2+) influx is also governed by RyR1 expression and contributes in the regulation of [Ca(2+)](rest) in skeletal myotubes. PMID: 20207743
50. Our findings indicate that in retrograde signaling, the functional state of RyR1 influences conformational changes of the DHPR involved in activation of L-type current PMID: 19802526

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KEGG: mmu:20190

STRING: 10090.ENSMUSP00000137123

UniGene: Mm.439745