Recombinant Mouse Transcription factor MafA (Mafa)

1. Data suggest that hepatocytes can be reprogrammed into insulin-producing cells in vivo by transfection of neurogenin-3, Pdx1, and MafA genes using non-viral hydrodynamics injection; this procedure was used in treatment of streptozotocin diabetes; fasting blood glucose was reduced to normal. (Pdx1 = pancreatic and duodenal homeobox 1; MafA = v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A) PMID: 28100871
2. Mafa was found to both potentiate the ability of Pdx1 to induce beta-cell formation from Ngn3-positive endocrine precursors and enable Pdx1 to produce beta-cells from alpha-cells. PMID: 28223284
3. is necessary for the maintenance of normal insulin levels even in embryos. PMID: 25912440
4. endogenous small-Maf factors negatively regulate beta-cell function by competing for MafA binding, and thus, the inhibition of small-Maf activity can improve beta-cell function PMID: 25763640
5. Data, including data from studies using transgenic/knockout mice, confirm the expression of Mafa and Mafb is specific to insulin-secreting cells of the pancreas. PMID: 25273397
6. These results suggest that MafA regulates the postnatal proliferation of beta-cells via prolactin signaling. PMID: 25126749
7. results illustrate how consequential the reduction in Mafa activity is to islet beta-cell function under pathophysiological conditions. PMID: 25645923
8. Results not only clearly define why MafA is an essential transcriptional regulator of islet beta-cells, but also why cell maturation involves coordinated actions with MafB. PMID: 24520122
9. MAFA, MAFB, NKX6.1, and PDX1 activity provides a gauge of islet beta cell function, with loss of MAFA (and/or MAFB) representing an early indicator of beta cell inactivity PMID: 23863625
10. under oxidative and nonoxidative conditions p38 MAPK directly binds to MafA and triggers MafA degradation via ubiquitin proteasomal pathway. PMID: 23660596
11. In this study, we tried to establish an effective method of differentiation through the protein transduction of three transcription factors (Pdx1, NeuroD, and MafA) important to pancreatic beta cell development. PMID: 24292793
12. We found that forcing MafA transgene expression, out of its normal developmental context, in Ngn3(+) endocrine progenitors blocked endocrine differentiation and prevented the formation of hormone(+) cells. PMID: 24183936
13. We identified MAFA as a target that is downregulated by miR-204. The newly identified TXNIP-miR-204-MAFA-insulin pathway may contribute to diabetes progression. PMID: 23975026
14. Findings suggest that Onecut1 suppresses MafA gene expression through the Foxa2-binding site. PMID: 23775071
15. Characterization of an apparently novel beta-cell line-enriched 80-88 kDa transcriptional activator of the MafA and Pdx1 genes. PMID: 23269676
16. MicroRNA-30d induces insulin transcription factor MafA and insulin production by targeting mitogen-activated protein 4 kinase 4 (MAP4K4) in pancreatic beta-cells. PMID: 22733810
17. Combined transfection of the three transcriptional factors, PDX-1, NeuroD1, and MafA, causes differentiation of bone marrow mesenchymal stem cells into insulin-producing cells PMID: 22761608
18. Results indicate that Pdx1 and MafA drive DE progenitors towards insulin-producing cells. PMID: 22563503
19. mechanism of transdifferentiation of pancreatic exocrine cells to beta (beta) cells in vivo by MafA PMID: 22150363
20. Data show that when injected in utero into living mouse embryos, TAT-MafA significantly up-regulates target genes and induces enhanced insulin production as well as cytoarchitectural changes consistent with faster islet maturation. PMID: 21857924
21. PA28gamma stimulates MAFA degradation through a novel molecular mechanism that is distinct from that for the degradation of p21 PMID: 21830322
22. Compromised MafA expression contributes to beta-cell dysfunction in maturity onset diabetes of young mice. MafA mutant mice manifested symptoms associated with human type 2 diabetes. PMID: 21193557
23. ATF2 interacts with beta-cell-enriched transcription factors, MafA, Pdx1, and beta2, and activates insulin gene transcription. PMID: 21278380
24. Data show that SUMOylation is a functional post-translational modification of MafA that negatively regulates its transcriptional and transforming activities. PMID: 20718938
25. The bZIP transcription factor MafA is identified as the first specific marker of a subpopulation of "early c-ret" positive neurons characterized by medium-to-large diameters. PMID: 20213756
26. Insight into the sequential manner by which MafA regulates islet beta-cell formation and maturation in mice. PMID: 20627934
27. Polymorphisms of MafA associate with reduced expression of insulin in the thymus and susceptibility to type 1 diabetes in the NOD mouse as well as human type 1 diabetes. PMID: 20682694
28. Correct spatial and inducible regulation of Mafa involves cross talk between trans-acting factors binding to multiple conserved cis elements located within distinct regions of the promoter. PMID: 20584984
29. It is likely that the augmented expression of c-Jun in diabetic islets decreases MafA expression and thereby reduces insulin biosynthesis, which is often observed in type 2 diabetes. PMID: 20424231
30. a novel relationship between the phosphoamino acid-rich transactivation and b-Zip domains in controlling MafA DNA-binding activity. PMID: 20208071
31. Using conditional MafA knockout mice, it is demonstrated that MafA identifies the early ret-expressing sensory neurons in the dorsal root ganglia. PMID: 20213756
32. Our results provide evidence that genetic interactions involving Ret and MafA progressively promote the differentiation and diversification of LTMs. PMID: 20064392
33. MafA is a beta-cell-specific and glucose-regulated transcriptional activator for insulin gene expression and thus may be involved in the function and development of beta-cells as well as in the pathogenesis of diabetes PMID: 12368292
34. These results strongly suggested that MafA was the beta-cell-enriched component of the RIPE3b1 activator PMID: 12917329
35. mafA has a role in regulating insulin gene expression in the liver PMID: 15664997
36. These results show that MafA is a key regulator of glucose-stimulated insulin secretion in vivo. PMID: 15923615
37. FoxO1 protects against pancreatic beta cell failure through Neurod and Mafa induction. PMID: 16154098
38. Results describe the chronological sequence of binding of MafA, E47/beta2 and PDX-1 to the insulin promoter in living beta-cells. PMID: 16412423
39. MafB may have a dual role in regulating embryonic differentiation of both beta- and alpha-cells while MafA may regulate replication/survival and function of beta-cells after birth. PMID: 16580660
40. Data show that FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. PMID: 16847327
41. MafA expression mediated by high glucose requires flux through the hexosamine biosynthetic pathway and the O-linked glycosylation of an unknown protein(s) by UDP-N-acetylglucosaminyl transferase PMID: 17142462
42. Ripe3b1 induces islet cell differentiation in hepatic progenitor cells. PMID: 17239820
43. Results suggest possible role of mafA in the pathophysiological states of impaired metabolic responses or inflammatory reactions. PMID: 17346669
44. MafA has a critical role in islet beta-cell function PMID: 17636040
45. Data show that MafA is constitutively phosphorylated by GSK3, and suggest a new glucose-sensing signaling pathway in islet beta cells that regulates insulin gene expression through the regulation of MafA protein stability. PMID: 17682063
46. MafA-dependent activation of insulin II gene promoters was inhibited in the presence of Smad2/Smad4 or Smad3/Smad4 and a constitutively active TGF-beta type I receptor and this inhibition was dependent upon the presence of MafA. PMID: 17927952
47. Significance of large Maf proteins to Pdx1 expression in beta cells, and in particular MafB during pancreatic development. PMID: 18522939
48. mobility of MafA S65A was profoundly affected upon SDS-PAGE, with the S65E and S65D mutants influenced less due to their ability to serve as substrates for glycogen synthase kinase 3 PMID: 19004825
49. study suggests that modification of MafA by SUMO modulates gene transcription and thereby beta cell function PMID: 19029092
50. p38 MAPK is a major regulator of MafA protein stability under oxidative stress PMID: 19407223

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KEGG: mmu:378435

STRING: 10090.ENSMUSP00000054226

UniGene: Mm.309589