Recombinant Mouse Voltage-dependent N-type calcium channel subunit alpha-1B (Cacna1b), partial

1. It is essential for presynaptic neurotransmitter release. PMID: 28391067
2. Blockade of Cav2.2 in inflammatory arthritis leads to up-regulation of the osteoclast activator RANKL and concomitant joint and bone destruction. PMID: 25733371
3. Results identified altered synaptic transmission in the olfactory system of Cav2.2-deficient mice and suggest that the olfactory system could become an attractive model to learn more about this channel and the consequences of its removal PMID: 25195871
4. Both pharmacological blockade of N-type calcium channels and their genetic titration improved cardiac autonomic balance and prevented lethal arrhythmias in a mouse model of dilated cardiomyopathy and sudden arrhythmic death. PMID: 25100767
5. Gaba B receptors were found to mediate Cav2.2 channel inhibition. PMID: 25425625
6. Results demonstrate that sensory neurons from Nf1+/- mice, exhibit increased N-type (Cav2.2) ICa and likely account for the increased release of substance P and calcitonin gene-related peptide that occurs in Nf1+/- sensory neurons PMID: 24755485
7. data suggest that the different roles that Ca(V)2.1 and Ca(V)2.2 play in MNC secretion may be a result of the different levels of expression of Ca(V)2.1 in VP and OT MNCs PMID: 24344901
8. Although the mechanism of its activation is not clear at present, activation of N-type VDCC expressed in non-excitable microglial cells contributes to the pathophysiology of neuropathic pain. PMID: 24887565
9. CaV2.2 and alpha2delta-1 are intimately associated at the plasma membrane PMID: 24889613
10. Oxidative stress-related endothelial dysfunction induced by angiotensin II is suppressed in mice lacking the N-type VDCC alpha1B subunit. PMID: 23537646
11. Blocking Cav2.2 channels abolishes respiratory activity in all brainstem slices from Cav2.1 genetically ablated animals. PMID: 23426690
12. High focal axoplasmic Ca2+ levels correlate with focal aggregation of the reverse Na+/Ca2+ exchanger 1, voltage-gated N-type Ca2+ channel alpha1B subunit, and actin at the sites of spheroids in individual axons. PMID: 22933787
13. This study demonistrated that Cacna1b gene expression in mouse dorsal raphe nucleus PMID: 22534482
14. this study suggested that highly specialized, discrete cellular responsiveness in vivo can be attributed to alternative splicing events regulated at the level of individual neurons. PMID: 20852623
15. These results suggest that Ca(2+) in the central nervous system modulates various neurophysiological functions, such as locomotor activity, long-term memory, and sensorimotor gating through the alpha(1B) subunit of the N-type calcium channels. PMID: 19963013
16. Cav2.2-/- mice were hyperactive and displayed vigilance state differences during the light phase indicating a role of the N-type Ca2+ channel in activity and vigilance state control PMID: 12890773
17. A possible explanation for the normal behavior of Cacna1B-deficient mice is compensation by increased expression of the Cacna1a gene. PMID: 15050706
18. the synprint site is necessary for efficient coupling of Ca2+ influx through alpha1B-containing Ca2+ channels to exocytosis PMID: 15471993
19. In mice lacking functional N-type calcium channels (Cav2.2 null mice), voluntary ethanol consumption is reduced and place preference is developed only at a low dose of ethanol. PMID: 15525770
20. Protein-protein interactions with the synprint site must cooperate with other targeting mechanisms in the incorporation of CaV2.2 into presynaptic specializations of hippocampal neurons. PMID: 16930401
21. results demonstrate that N-type Ca(2+) channels are required for hippocampus-dependent learning and memory, and certain forms of long-term potentiation PMID: 16939638
22. suggest that N-type Ca(2+) channels at the dorsal raphe nucleus have a key role in the control of aggression PMID: 19004821
23. Munc18: a presynaptic transmitter release site N type (CaV2.2) calcium channel interacting protein. PMID: 19170253
24. Inhibition of sympathetic N-type voltage-gated Ca2+ influx through Cav2.2 channels underlies the reduction in norepinephrine release during colitis. PMID: 19264956
25. Tumour necrosis factor alpha activates nuclear factor kappaB signalling to reduce N-type voltage-gated Ca2+ current in postganglionic sympathetic neurons. PMID: 19403618
26. CRMP-2 and Cav2.2 interaction modulates Ca(2+) influx into nerve terminals. PMID: 19755421

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KEGG: mmu:12287

STRING: 10090.ENSMUSP00000037416

UniGene: Mm.4424