Recombinant Protein lin-12 (lin-12), partial

1. These findings provide additional evidence highlighting the roles of LIN-12/Notch signaling in coordinating the formation of various components of the functional C. elegans egg-laying system. PMID: 24512688
2. LIN-12 signaling is necessary for the suppression of lag-1 expression in the anchor cell in Caenorhabditis elegans. PMID: 23483278
3. Here we identify two cis-regulatory regions from lin-12, both of them are specified by the presence of a conserved EXD/HOX composite binding site. the two Notch paralogs in the C. elegans nervous system. PMID: 23305862
4. The termination of NOTCH signaling is tightly linked to cell-cycle progression. PMID: 23047528
5. LIN-14 inhibition of LIN-12 contributes to precision and timing of C. elegans vulval fate patterning. PMID: 20951046
6. Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans PMID: 12478297
7. findings show that in addition to the MAPK phosphatase lip-1, LIN-12 activates expression of many different negative regulators of the EGFR-MAPK pathway in vulva precursor cells, which seem likely to inhibit activity of this pathway at different steps PMID: 14752159
8. Lateral signal-inhibiting activity of LIN-12 resides in the extracellular domain and occurs at the apical surface of the vulval precursor cells. PMID: 16236769
9. results suggest that lin-12, mir-61, and vav-1 form a feedback loop that helps maximize lin-12 activity in spatial patterning 2 of vulval precursor cells PMID: 16239437
10. egl-43 acts downstream of or parallel to lin-12 in the anchor cell and ventral uterine precursor cell cell-fate specification at an early developmental stage PMID: 17215301
11. Loss of sel-2 activity leads to basolateral mislocalization and increased accumulation of LIN-12 in vulval precursor cells (VPCs) in which LET-23 is not active, and to impaired downregulation of basolateral LET-23 in VPCs in which LIN-12 is active. PMID: 17215302
12. study determined that dual regulation by LIN-12 and FOS-1 is required for egl-13 expression at specification and for complete rescue of egl-13 mutants PMID: 17942488
13. Results suggest that the LIN-12/Notch pathway and the Sma/Mab TGFbeta pathway function independently in regulating dorsoventral patterning of the M lineage, with LIN-12/Notch required for ventral M lineage fates. PMID: 18036582
14. C. elegans OSM-11 and homologous proteins act as coactivators for Notch receptors, allowing precise regulation of Notch receptor signaling in developmental programs in both vertebrates and invertebrates. PMID: 18700817

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KEGG: cel:CELE_R107.8

STRING: 6239.R107.8

UniGene: Cel.10278